KCND3

Potassium voltage-gated channel, Shal-related subfamily, member 3, also known as KCND3 or K_v4.3, is a human gene.cite web | title = Entrez Gene: KCND3 potassium voltage-gated channel, Shal-related subfamily, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3752| accessdate = ]

PBB_Summary
section_title =
summary_text = Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene.cite web | title = Entrez Gene: KCND3 potassium voltage-gated channel, Shal-related subfamily, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3752| accessdate = ]

ee also

* Voltage-gated potassium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gutman GA, Chandy KG, Grissmer S, "et al." |title=International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 473–508 |year= 2006 |pmid= 16382104 |doi= 10.1124/pr.57.4.10
*cite journal | author=Serôdio P, Vega-Saenz de Miera E, Rudy B |title=Cloning of a novel component of A-type K+ channels operating at subthreshold potentials with unique expression in heart and brain. |journal=J. Neurophysiol. |volume=75 |issue= 5 |pages= 2174–9 |year= 1997 |pmid= 8734615 |doi=
*cite journal | author=Kong W, Po S, Yamagishi T, "et al." |title=Isolation and characterization of the human gene encoding Ito: further diversity by alternative mRNA splicing. |journal=Am. J. Physiol. |volume=275 |issue= 6 Pt 2 |pages= H1963–70 |year= 1999 |pmid= 9843794 |doi=
*cite journal | author=Dilks D, Ling HP, Cockett M, "et al." |title=Cloning and expression of the human kv4.3 potassium channel. |journal=J. Neurophysiol. |volume=81 |issue= 4 |pages= 1974–7 |year= 1999 |pmid= 10200233 |doi=
*cite journal | author=Isbrandt D, Leicher T, Waldschütz R, "et al." |title=Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA). |journal=Genomics |volume=64 |issue= 2 |pages= 144–54 |year= 2000 |pmid= 10729221 |doi= 10.1006/geno.2000.6117
*cite journal | author=Postma AV, Bezzina CR, de Vries JF, "et al." |title=Genomic organisation and chromosomal localisation of two members of the KCND ion channel family, KCND2 and KCND3. |journal=Hum. Genet. |volume=106 |issue= 6 |pages= 614–9 |year= 2000 |pmid= 10942109 |doi=
*cite journal | author=Deschênes I, Tomaselli GF |title=Modulation of Kv4.3 current by accessory subunits. |journal=FEBS Lett. |volume=528 |issue= 1-3 |pages= 183–8 |year= 2002 |pmid= 12297301 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ren X, Shand SH, Takimoto K |title=Effective association of Kv channel-interacting proteins with Kv4 channel is mediated with their unique core peptide. |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 43564–70 |year= 2003 |pmid= 12928444 |doi= 10.1074/jbc.M302337200
*cite journal | author=Hatano N, Ohya S, Muraki K, "et al." |title=Two arginines in the cytoplasmic C-terminal domain are essential for voltage-dependent regulation of A-type K+ current in the Kv4 channel subfamily. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5450–9 |year= 2004 |pmid= 14645239 |doi= 10.1074/jbc.M302034200
*cite journal | author=Scannevin RH, Wang K, Jow F, "et al." |title=Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1. |journal=Neuron |volume=41 |issue= 4 |pages= 587–98 |year= 2004 |pmid= 14980207 |doi=
*cite journal | author=Zicha S, Xiao L, Stafford S, "et al." |title=Transmural expression of transient outward potassium current subunits in normal and failing canine and human hearts. |journal=J. Physiol. (Lond.) |volume=561 |issue= Pt 3 |pages= 735–48 |year= 2005 |pmid= 15498806 |doi= 10.1113/jphysiol.2004.075861
*cite journal | author=Frank-Hansen R, Larsen LA, Andersen P, "et al." |title=Mutations in the genes KCND2 and KCND3 encoding the ion channels Kv4.2 and Kv4.3, conducting the cardiac fast transient outward current (ITO,f), are not a frequent cause of long QT syndrome. |journal=Clin. Chim. Acta |volume=351 |issue= 1-2 |pages= 95–100 |year= 2005 |pmid= 15563876 |doi= 10.1016/j.cccn.2004.08.017
*cite journal | author=Baltaev R, Strutz-Seebohm N, Korniychuk G, "et al." |title=Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes. |journal=Pflugers Arch. |volume=450 |issue= 1 |pages= 26–33 |year= 2005 |pmid= 15578212 |doi= 10.1007/s00424-004-1369-z
*cite journal | author=Radicke S, Cotella D, Graf EM, "et al." |title=Expression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3. |journal=J. Physiol. (Lond.) |volume=565 |issue= Pt 3 |pages= 751–6 |year= 2005 |pmid= 15890703 |doi= 10.1113/jphysiol.2005.087312
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Lundby A, Olesen SP |title=KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel. |journal=Biochem. Biophys. Res. Commun. |volume=346 |issue= 3 |pages= 958–67 |year= 2006 |pmid= 16782062 |doi= 10.1016/j.bbrc.2006.06.004
*cite journal | author=Ahmed I, Cosen-Binker LI, Leung YM, "et al." |title=Modulation of the K(v)4.3 channel by syntaxin 1A. |journal=Biochem. Biophys. Res. Commun. |volume=358 |issue= 3 |pages= 789–95 |year= 2007 |pmid= 17506992 |doi= 10.1016/j.bbrc.2007.04.182
*cite journal | author=Potapova IA, Cohen IS, Doronin SV |title=Voltage-gated ion channel Kv4.3 is associated with Rap guanine nucleotide exchange factors and regulates angiotensin receptor type 1 signaling to small G-protein Rap. |journal=FEBS J. |volume=274 |issue= 17 |pages= 4375–84 |year= 2007 |pmid= 17725712 |doi= 10.1111/j.1742-4658.2007.05966.x

External links

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