KCND2

Potassium voltage-gated channel, Shal-related subfamily, member 2, also known as KCND2 or K_v4.2, is a human gene.cite web | title = Entrez Gene: KCND2 potassium voltage-gated channel, Shal-related subfamily, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3751| accessdate = ]

PBB_Summary
section_title =
summary_text = Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels.cite web | title = Entrez Gene: KCND2 potassium voltage-gated channel, Shal-related subfamily, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3751| accessdate = ]

ee also

* Voltage-gated potassium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gutman GA, Chandy KG, Grissmer S, "et al." |title=International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 473–508 |year= 2006 |pmid= 16382104 |doi= 10.1124/pr.57.4.10
*cite journal | author=Kong W, Po S, Yamagishi T, "et al." |title=Isolation and characterization of the human gene encoding Ito: further diversity by alternative mRNA splicing. |journal=Am. J. Physiol. |volume=275 |issue= 6 Pt 2 |pages= H1963–70 |year= 1999 |pmid= 9843794 |doi=
*cite journal | author=Kikuno R, Nagase T, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197–205 |year= 1999 |pmid= 10470851 |doi=
*cite journal | author=Kurschner C, Yuzaki M |title=Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein. |journal=J. Neurosci. |volume=19 |issue= 18 |pages= 7770–80 |year= 1999 |pmid= 10479680 |doi=
*cite journal | author=Zhu XR, Wulf A, Schwarz M, "et al." |title=Characterization of human Kv4.2 mediating a rapidly-inactivating transient voltage-sensitive K+ current. |journal=Recept. Channels |volume=6 |issue= 5 |pages= 387–400 |year= 1999 |pmid= 10551270 |doi=
*cite journal | author=An WF, Bowlby MR, Betty M, "et al." |title=Modulation of A-type potassium channels by a family of calcium sensors. |journal=Nature |volume=403 |issue= 6769 |pages= 553–6 |year= 2000 |pmid= 10676964 |doi= 10.1038/35000592
*cite journal | author=Isbrandt D, Leicher T, Waldschütz R, "et al." |title=Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA). |journal=Genomics |volume=64 |issue= 2 |pages= 144–54 |year= 2000 |pmid= 10729221 |doi= 10.1006/geno.2000.6117
*cite journal | author=Postma AV, Bezzina CR, de Vries JF, "et al." |title=Genomic organisation and chromosomal localisation of two members of the KCND ion channel family, KCND2 and KCND3. |journal=Hum. Genet. |volume=106 |issue= 6 |pages= 614–9 |year= 2000 |pmid= 10942109 |doi=
*cite journal | author=Petrecca K, Miller DM, Shrier A |title=Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin. |journal=J. Neurosci. |volume=20 |issue= 23 |pages= 8736–44 |year= 2001 |pmid= 11102480 |doi=
*cite journal | author=Bähring R, Dannenberg J, Peters HC, "et al." |title=Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23888–94 |year= 2001 |pmid= 11287421 |doi= 10.1074/jbc.M101320200
*cite journal | author=Nakamura TY, Pountney DJ, Ozaita A, "et al." |title=A role for frequenin, a Ca2+-binding protein, as a regulator of Kv4 K+-currents. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 22 |pages= 12808–13 |year= 2001 |pmid= 11606724 |doi= 10.1073/pnas.221168498
*cite journal | author=Morohashi Y, Hatano N, Ohya S, "et al." |title=Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4. |journal=J. Biol. Chem. |volume=277 |issue= 17 |pages= 14965–75 |year= 2002 |pmid= 11847232 |doi= 10.1074/jbc.M200897200
*cite journal | author=Eldstrom J, Doerksen KW, Steele DF, Fedida D |title=N-terminal PDZ-binding domain in Kv1 potassium channels. |journal=FEBS Lett. |volume=531 |issue= 3 |pages= 529–37 |year= 2002 |pmid= 12435606 |doi=
*cite journal | author=Schrader LA, Anderson AE, Mayne A, "et al." |title=PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex. |journal=J. Neurosci. |volume=22 |issue= 23 |pages= 10123–33 |year= 2002 |pmid= 12451113 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Shin BK, Wang H, Yim AM, "et al." |title=Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7607–16 |year= 2003 |pmid= 12493773 |doi= 10.1074/jbc.M210455200
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Wong W, Schlichter LC |title=Differential recruitment of Kv1.4 and Kv4.2 to lipid rafts by PSD-95. |journal=J. Biol. Chem. |volume=279 |issue= 1 |pages= 444–52 |year= 2004 |pmid= 14559911 |doi= 10.1074/jbc.M304675200
*cite journal | author=Kim LA, Furst J, Butler MH, "et al." |title=Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5549–54 |year= 2004 |pmid= 14623880 |doi= 10.1074/jbc.M311332200

External links

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