KCNIP1

Kv channel interacting protein 1, also known as KCNIP1, is a human gene.cite web | title = Entrez Gene: KCNIP1 Kv channel interacting protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30820| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.cite web | title = Entrez Gene: KCNIP1 Kv channel interacting protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30820| accessdate = ]

References

ee also

* Voltage-gated potassium channel

Further reading

PBB_Further_reading
citations =
*cite journal | author=An WF, Bowlby MR, Betty M, "et al." |title=Modulation of A-type potassium channels by a family of calcium sensors. |journal=Nature |volume=403 |issue= 6769 |pages= 553–6 |year= 2000 |pmid= 10676964 |doi= 10.1038/35000592
*cite journal | author=Bähring R, Dannenberg J, Peters HC, "et al." |title=Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23888–94 |year= 2001 |pmid= 11287421 |doi= 10.1074/jbc.M101320200
*cite journal | author=Nakamura TY, Nandi S, Pountney DJ, "et al." |title=Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2. |journal=FEBS Lett. |volume=499 |issue= 3 |pages= 205–9 |year= 2001 |pmid= 11423117 |doi=
*cite journal | author=Kutsenko AS, Gizatullin RZ, Al-Amin AN, "et al." |title=NotI flanking sequences: a tool for gene discovery and verification of the human genome. |journal=Nucleic Acids Res. |volume=30 |issue= 14 |pages= 3163–70 |year= 2002 |pmid= 12136098 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Shibata R, Misonou H, Campomanes CR, "et al." |title=A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels. |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36445–54 |year= 2003 |pmid= 12829703 |doi= 10.1074/jbc.M306142200
*cite journal | author=Van Hoorick D, Raes A, Keysers W, "et al." |title=Differential modulation of Kv4 kinetics by KCHIP1 splice variants. |journal=Mol. Cell. Neurosci. |volume=24 |issue= 2 |pages= 357–66 |year= 2004 |pmid= 14572458 |doi=
*cite journal | author=Scannevin RH, Wang K, Jow F, "et al." |title=Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1. |journal=Neuron |volume=41 |issue= 4 |pages= 587–98 |year= 2004 |pmid= 14980207 |doi=
*cite journal | author=Lin YL, Lin SR, Wu TT, Chang LS |title=Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins. |journal=Biochem. Biophys. Res. Commun. |volume=319 |issue= 3 |pages= 720–4 |year= 2004 |pmid= 15184042 |doi= 10.1016/j.bbrc.2004.05.064
*cite journal | author=Lin YL, Chen CY, Cheng CP, Chang LS |title=Protein-protein interactions of KChIP proteins and Kv4.2. |journal=Biochem. Biophys. Res. Commun. |volume=321 |issue= 3 |pages= 606–10 |year= 2004 |pmid= 15358149 |doi= 10.1016/j.bbrc.2004.07.006
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Pruunsild P, Timmusk T |title=Structure, alternative splicing, and expression of the human and mouse KCNIP gene family. |journal=Genomics |volume=86 |issue= 5 |pages= 581–93 |year= 2005 |pmid= 16112838 |doi= 10.1016/j.ygeno.2005.07.001
*cite journal | author=Pioletti M, Findeisen F, Hura GL, Minor DL |title=Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer. |journal=Nat. Struct. Mol. Biol. |volume=13 |issue= 11 |pages= 987–95 |year= 2007 |pmid= 17057713 |doi= 10.1038/nsmb1164

External links

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