Neuronal calcium sensor

Neuronal calcium sensor

Neuronal Calcium Sensor is a large family of proteins which work as calcium dependent molecular switches and includes members like Frequenin (NCS1), recoverin, GCAP, neurocalcin, visinin etc [1]. All the members carry 4 EF hand motifs (out of which only 2 or 3 bind calcium) and an N-myristoyl group.[2]

Members of NCS family

  • Highly evolutionarily conserved [3]

KCNIP1, KCNIP2, Calsenilin or DREAM/KChIP-3/KCNIP3 (downstream regulatory element antagonist modulator/potassium channel interacting protein), KCNIP4


  1. ^ Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005. 
  2. ^ Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203–9. doi:10.1016/j.tins.2004.01.010. PMID 15046879. 
  3. ^ Weiss JL, Hui H, Burgoyne RD (2010). "Neuronal calcium sensor-1 regulation of calcium channels, secretion, and neuronal outgrowth.". Cell Mol Neurobiol. 30 (8): 1283–92. PMID 21104311. 

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