Matrix gla protein

Matrix gla protein
Matrix Gla protein
External IDs OMIM154870 MGI96976 HomoloGene693 GeneCards: MGP Gene
Species Human Mouse
Entrez 4256 17313
Ensembl ENSG00000111341 ENSMUSG00000030218
UniProt P08493 P19788
RefSeq (mRNA) NM_000900.3 NM_008597.3
RefSeq (protein) NP_000891.2 NP_032623.1
Location (UCSC) Chr 12:
15.03 – 15.04 Mb
Chr 6:
136.82 – 136.82 Mb
PubMed search [1] [2]

Matrix gla protein (MGP) is a protein found in numerous body tissues that requires vitamin K for its optimum function. It is present in bone (together with the related vitamin K-dependent protein osteocalcin), as well as in heart, kidney and lung. In bone, its production is increased by vitamin D.



The MGP was linked to the short arm of chromosome 12 in 1990.[1]


MGP and osteocalcin are both calcium-binding proteins that may participate in the organisation of bone tissue. Both have glutamate residues that are post-translationally carboxylated by the enzyme gamma-glutamyl carboxylase in a reaction that requires Vitamin K hydroquinone. This process also occurs with a number of proteins involved in coagulation: prothrombin, factor VII, factor IX and factor X, protein C, protein S and protein Z.

Role in disease

Abnormalities in the MGP gene have been linked with Keutel syndrome, a rare condition characterised by abnormal calcium deposition in cartilage, peripheral stenosis of the pulmonary artery, and midfacial hypoplasia.[2]

Mice that lack MGP develop to term but die within two months as a result of arterial calcification which leads to blood-vessel rupture.[3]


  1. ^ Cancela L, Hsieh CL, Francke U, Price PA (1990). "Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene". J. Biol. Chem. 265 (25): 15040–8. PMID 2394711. 
  2. ^ Munroe PB, Olgunturk RO, Fryns JP et al. (1999). "Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome". Nat. Genet. 21 (1): 142–4. doi:10.1038/5102. PMID 9916809. 
  3. ^ Luo G, Ducy P, McKee MD et al. (March 1997). "Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein". Nature 386 (6620): 78–81. doi:10.1038/386078a0. PMID 9052783. 

External links

Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • Gla domain — Pfam box Symbol = Gla Name = width =220 caption = Anchoring of Coagulation factor VIIa to the membrane through its GLA domain Pfam= PF00594 InterPro= IPR000294 SMART= PROSITE = PDOC00011 SCOP = 1cfi TCDB = OPM family= 97 OPM protein= 1pfx… …   Wikipedia

  • Protein — A large molecule composed of one or more chains of amino acids in a specific order determined by the base sequence of nucleotides in the DNA coding for the protein. Proteins are required for the structure, function, and regulation of the body s… …   Medical dictionary

  • Extracellular matrix — Illustration depicting extracellular matrix (basement membrane and interstitial matrix) in relation to epithelium, endothelium and connective tissue Latin …   Wikipedia

  • S-100 protein — S 100/ICaBP type calcium binding domain Identifiers Symbol S 100 Pfam PF01023 InterPro …   Wikipedia

  • Protein S — is a vitamin K dependent plasma glycoprotein synthesized in the liver. In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b. FunctionThe best characterized function of Protein S is its… …   Wikipedia

  • Vitamin K — has also been used as a slang term for ketamine, an unrelated anaesthetic. Vitamin K1 (phylloquinone). Both forms of the vitamin contain a functional naphthoquinone ring and an aliphatic side chain. Phylloquinone has a phytyl side chain …   Wikipedia

  • Osteocalcin — Bone gamma carboxyglutamate (gla) protein PDB rendering based on 1q8h …   Wikipedia

  • Intracellular calcium-sensing proteins — are proteins that act in the second messenger system. Examples include: calmodulin calnexin calreticulin gelsolin External links MeSH Intracellular+Calcium Sensing+Proteins …   Wikipedia

  • Collagen — Tropocollagen triple helix Collagen /ˈkɒlədʒɨn/ is a group of naturally occurring proteins found in animals, especially in the flesh and connective tissues of mammals.[1] It is the main component of connectiv …   Wikipedia

  • Decorin — PDB rendering based on 1xcd …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”