Elastin

Elastin

protein
Name = Elastin
caption =


width =
HGNCid = 3327
Symbol = ELN
AltSymbols =
EntrezGene = 2006
OMIM = 130160
RefSeq = NM_000501
UniProt = P15502
PDB =
ECnumber =
Chromosome = 7
Arm = q
Band = 11
LocusSupplementaryData = .1-21.1

Elastin is a protein in connective tissue that is elastic and allows many tissues in the body to resume their shape after stretching or contracting. Elastin helps skin to return to its original position when it is poked or pinched. Elastin is also an important load-bearing tissue in the bodies of mammals and used in places where mechanical energy is required to be stored.

Composition

Elastin is primarily composed of the amino acids glycine, valine, alanine, and proline. It is a specialized protein with a molecular weight of 64 to 66 kDa, and an irregular or random coil conformation made up of 830 amino acids.

Elastin is made by linking many soluble tropoelastin protein molecules, in a reaction catalyzed by lysyl oxidase, to make a massive insoluble, durable cross-linked array. The amino acid responsible for these cross-links is lysine.

Desmosine and isodesmosine are both found in elastin.

Locations in body

Elastin serves an important function in arteries and is particularly abundant in large elastic blood vessels such as the aorta. Elastin is also very important in the lungs, elastic ligaments, the skin, the bladder, elastic cartilage, and the intervertebral disc above the sacroiliac. It is present in all vertebrates above the jawless fish [Sage EH & Gray WR 1977 Evolution of elastin and elastin structure, p 291. in; Advances in Experimental Medicine and Biology, vol. 79 LB Sandberg & C Franzblaw, eds) Plenum Press, NY & London] .

ee also

* Elastic fibers
* Elastin receptor

References

External links

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Look at other dictionaries:

  • Elastin — Masse/Länge Primärstruktur 760 Aminosäuren …   Deutsch Wikipedia

  • Elastin — E*las tin, n. [Elastic + in.] (Physiol. Chem.) A nitrogenous substance, somewhat resembling albumin, which forms the chemical basis of elastic tissue. It is very insoluble in most fluids, but is gradually dissolved when digested with either… …   The Collaborative International Dictionary of English

  • elastin — elastin. См. эластин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Elastīn — Elastīn, Grundsubstanz des tierischen elastischen Gewebes, das in Bändern, Muskelscheiden, im Nackenband etc. auftritt, bildet nach der Reinigung durch Wasser, Alkohol etc. eine spröde, gelbliche, deutlich faserige Masse, die in Wasser aufquillt… …   Meyers Großes Konversations-Lexikon

  • Elastin — Elastīn, Hauptbestandteil der elastischen Gewebe des tierischen Organismus, ein dem Eiweiß nahestehender Körper …   Kleines Konversations-Lexikon

  • elastin — [ē las′tin] n. [see ELASTIC & IN1] a yellow, fibrous protein that is the basic constituent of elastic connective tissue, as in a lung or artery …   English World dictionary

  • elastin — Glycoprotein (70 kD) randomly coiled and cross linked to form elastic fibres that are found in connective tissue. Like collagen, the amino acid composition is unusual with 30% of residues being glycine and with a high proline content. Cross… …   Dictionary of molecular biology

  • Elastin — Elas|tin 〈n.; s; unz.; Biol.〉 Gerüsteiweißstoff, Grundsubstanz des elast. Gewebes * * * E|las|tin [zu ↑ Elastizität], das; s, e: als Hauptbestandteil elastischer Fasern in Bindegeweben, Sehnen u. Gefäßwandungen verbreitetes, mit ↑ Kollagen… …   Universal-Lexikon

  • Elastin receptor — protein Name=elastin receptor 1, 67kDa caption= width= HGNCid=3329 Symbol=ELNR1 AltSymbols= EntrezGene=2008 OMIM= RefSeq= UniProt= PDB= ECnumber= Chromosome= Arm= Band= LocusSupplementaryData=Elastin receptor is the term used to describe a… …   Wikipedia

  • elastin — noun Etymology: International Scientific Vocabulary, from New Latin elasticus Date: 1875 a protein that is similar to collagen and is the chief constituent of elastic fibers …   New Collegiate Dictionary

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