Prolyl hydroxylase

Prolyl hydroxylase

Prolyl hydroxylase (or procollagen-proline dioxygenase) is an enzyme involved in the production of collagen, acting to hydroxylate proline to hydroxyproline.

It requires vitamin C as a cofactor.

Reaction: Proline + α-ketoglutarate + O2 + Fe2+ → 4-hydroxyproline + Fe4+ + CO2 + succinate

The process requires ascorbic acid which provides Fe2+as a reductant to provide two electrons.

It is classified under EC number|1.14.11.2.

External links

*


Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • prolyl hydroxylase — See hydroxyproline …   Dictionary of molecular biology

  • Prolyl-4-Hydroxylase — Die Prolyl 4 Hydroxylase (4 PH) (auch: Procollagenprolin Dioxygenase) ist ein Enzymkomplex in Wirbeltieren, der die Hydroxylierung von Prolylresten in Proteinen katalysiert. Dabei handelt es sich um eine posttranslationale Modifikation. Sie ist… …   Deutsch Wikipedia

  • prolyl 4-hydroxylase — prolyl 4 hydroxylase. См. пролил 4 гидроксилаза. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • prolyl — The acyl radical of proline. p. dipeptidase an enzyme cleaving l p. amino acid bonds in dipeptides containing N terminal p. residues. SYN: iminodipeptidase, prolinase, prolylglycine dipeptidase. p. hydroxylase an enzyme that catalyzes the …   Medical dictionary

  • Phenylalanine hydroxylase — predicted 3D structure of phenylalanine hydroxylase …   Wikipedia

  • 21-Hydroxylase — Steroid 21 monooxygenase Identifiers EC number 1.14.99.10 CAS number 9029 68 9 …   Wikipedia

  • Steroid 11-beta-hydroxylase — Cytochrome P450, family 11, subfamily B, polypeptide 1 Identifiers Symbols CYP11B1; CPN1; CYP11B; DKFZp686B05283; FHI; FLJ36771; P450C11 External IDs …   Wikipedia

  • Cholesterol 7 alpha-hydroxylase — Cytochrome P450, family 7, subfamily A, polypeptide 1 PDB rendering based on 3dax …   Wikipedia

  • Dopamine beta hydroxylase — (dopamine beta monooxygenase) Identifiers Symbols DBH; DBM External IDs …   Wikipedia

  • prolyl 3-hydroxylase — pro·lyl 3 hy·drox·y·lase (proґləl hi drokґsə lās) an enzyme of the oxidoreductase class that catalyzes the hydroxylation at the 3 position of specific proline residues in nascent procollagen chains. The enzyme requires Fe2+,… …   Medical dictionary

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”