Tectorin alpha, also known as TECTA, is a human gene.cite web | title = Entrez Gene: TECTA tectorin alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7007| accessdate = ]

section_title =
summary_text = The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness.cite web | title = Entrez Gene: TECTA tectorin alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7007| accessdate = ]


Further reading

citations =
*cite journal | author=Van Camp G, Willems PJ, Smith RJ |title=Nonsyndromic hearing impairment: unparalleled heterogeneity. |journal=Am. J. Hum. Genet. |volume=60 |issue= 4 |pages= 758–64 |year= 1997 |pmid= 9106521 |doi=
*cite journal | author=Verhoeven K, Van Camp G, Govaerts PJ, "et al." |title=A gene for autosomal dominant nonsyndromic hearing loss (DFNA12) maps to chromosome 11q22-24. |journal=Am. J. Hum. Genet. |volume=60 |issue= 5 |pages= 1168–73 |year= 1997 |pmid= 9150164 |doi=
*cite journal | author=Hughes DC, Legan PK, Steel KP, Richardson GP |title=Mapping of the alpha-tectorin gene (TECTA) to mouse chromosome 9 and human chromosome 11: a candidate for human autosomal dominant nonsyndromic deafness. |journal=Genomics |volume=48 |issue= 1 |pages= 46–51 |year= 1998 |pmid= 9503015 |doi= 10.1006/geno.1997.5159
*cite journal | author=Verhoeven K, Van Laer L, Kirschhofer K, "et al." |title=Mutations in the human alpha-tectorin gene cause autosomal dominant non-syndromic hearing impairment. |journal=Nat. Genet. |volume=19 |issue= 1 |pages= 60–2 |year= 1998 |pmid= 9590290 |doi= 10.1038/ng0598-60
*cite journal | author=Balciuniene J, Dahl N, Borg E, "et al." |title=Evidence for digenic inheritance of nonsyndromic hereditary hearing loss in a Swedish family. |journal=Am. J. Hum. Genet. |volume=63 |issue= 3 |pages= 786–93 |year= 1998 |pmid= 9718342 |doi=
*cite journal | author=Mustapha M, Weil D, Chardenoux S, "et al." |title=An alpha-tectorin gene defect causes a newly identified autosomal recessive form of sensorineural pre-lingual non-syndromic deafness, DFNB21. |journal=Hum. Mol. Genet. |volume=8 |issue= 3 |pages= 409–12 |year= 1999 |pmid= 9949200 |doi=
*cite journal | author=Alloisio N, Morlé L, Bozon M, "et al." |title=Mutation in the zonadhesin-like domain of alpha-tectorin associated with autosomal dominant non-syndromic hearing loss. |journal=Eur. J. Hum. Genet. |volume=7 |issue= 2 |pages= 255–8 |year= 1999 |pmid= 10196713 |doi= 10.1038/sj.ejhg.5200273
*cite journal | author=Balciuniene J, Dahl N, Jalonen P, "et al." |title=Alpha-tectorin involvement in hearing disabilities: one gene--two phenotypes. |journal=Hum. Genet. |volume=105 |issue= 3 |pages= 211–6 |year= 2000 |pmid= 10987647 |doi=
*cite journal | author=Moreno-Pelayo MA, del Castillo I, Villamar M, "et al." |title=A cysteine substitution in the zona pellucida domain of alpha-tectorin results in autosomal dominant, postlingual, progressive, mid frequency hearing loss in a Spanish family. |journal=J. Med. Genet. |volume=38 |issue= 5 |pages= E13 |year= 2001 |pmid= 11333869 |doi=
*cite journal | author=Iwasaki S, Harada D, Usami S, "et al." |title=Association of clinical features with mutation of TECTA in a family with autosomal dominant hearing loss. |journal=Arch. Otolaryngol. Head Neck Surg. |volume=128 |issue= 8 |pages= 913–7 |year= 2002 |pmid= 12162770 |doi=
*cite journal | author=Naz S, Alasti F, Mowjoodi A, "et al." |title=Distinctive audiometric profile associated with DFNB21 alleles of TECTA. |journal=J. Med. Genet. |volume=40 |issue= 5 |pages= 360–3 |year= 2003 |pmid= 12746400 |doi=
*cite journal | author=Pfister M, Thiele H, Van Camp G, "et al." |title=A genotype-phenotype correlation with gender-effect for hearing impairment caused by TECTA mutations. |journal=Cell. Physiol. Biochem. |volume=14 |issue= 4-6 |pages= 369–76 |year= 2005 |pmid= 15319541 |doi= 10.1159/000080347
*cite journal | author=Plantinga RF, de Brouwer AP, Huygen PL, "et al." |title=A novel TECTA mutation in a Dutch DFNA8/12 family confirms genotype-phenotype correlation. |journal=J. Assoc. Res. Otolaryngol. |volume=7 |issue= 2 |pages= 173–81 |year= 2006 |pmid= 16718611 |doi= 10.1007/s10162-006-0033-z
*cite journal | author=Plantinga RF, Cremers CW, Huygen PL, "et al." |title=Audiological evaluation of affected members from a Dutch DFNA8/12 (TECTA) family. |journal=J. Assoc. Res. Otolaryngol. |volume=8 |issue= 1 |pages= 1–7 |year= 2007 |pmid= 17136632 |doi= 10.1007/s10162-006-0060-9
*cite journal | author=Meyer NC, Alasti F, Nishimura CJ, "et al." |title=Identification of three novel TECTA mutations in Iranian families with autosomal recessive nonsyndromic hearing impairment at the DFNB21 locus. |journal=Am. J. Med. Genet. A |volume=143 |issue= 14 |pages= 1623–9 |year= 2007 |pmid= 17431902 |doi= 10.1002/ajmg.a.31718
*cite journal | author=Meyer NC, Nishimura CJ, McMordie S, Smith RJ |title=Audioprofiling identifies TECTA and GJB2-related deafness segregating in a single extended pedigree. |journal=Clin. Genet. |volume=72 |issue= 2 |pages= 130–7 |year= 2007 |pmid= 17661817 |doi= 10.1111/j.1399-0004.2007.00828.x

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