Tenascin

Tenascin

Tenascins are extracellular matrix glycoproteins. They are abundant in the extracellular matrix of developing vertebrate embryos and they reappear around healing wounds and in the stroma of some tumors.

There are four members of the tenascin gene family: tenascin-C, tenascin-R, tenascin-X and tenascin-W.
* Tenascin-C is the founding member of the gene family. In the embryo it is made by migrating cells like the neural crest; it is also abundant in developing tendons, bone and cartilage.
* Tenascin-R is found in the developing and adult nervous system.
* Tenascin-X is found primarily in loose connective tissue; mutations in the human tenascin-X gene can lead to a form of Ehlers-Danlos syndrome. [cite journal |author=Bristow J, Carey W, Egging D, Schalkwijk J |title=Tenascin-X, collagen, elastin, and the Ehlers-Danlos syndrome |journal=Am J Med Genet C Semin Med Genet |volume=139 |issue=1 |pages=24–30 |year=2005 |pmid=16278880 |doi=10.1002/ajmg.c.30071]
* Tenascin-W is found in the kidney and in developing bone.

The basic structure is 14 EGF-like repeats towards the N-terminal end, and 8 or more fibronectin-III domains which vary upon species and variant.

Tenascin-C isoform is the best understood. It has anti-adhesive properties, causing cells in tissue culture to become rounded after it is added to the medium. One mechanism to explain this may come from its ability to bind to the extracellular matrix glycoprotein fibronectin and block fibronectin's interactions with specific syndecans. The expression of tenascin-C in the stroma of certain tumors is associated with a poor prognosis.

References

*
*
*
*

External links

*


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Tenascin C — (hexabrachion), also known as TNC, is a human gene. PBB Summary section title = summary text = ee also* TenascinFurther readingPBB Further reading citations = *cite journal | author=Imanaka Yoshida K, Hiroe M, Yoshida T |title=Interaction between …   Wikipedia

  • Tenascin X — protein Name=tenascin XB caption= width= HGNCid=11976 Symbol=TNXB AltSymbols=TNXB1, TNXB2 EntrezGene=7148 OMIM=600985 RefSeq=NM 019105 UniProt=P22105 PDB= ECnumber= Chromosome=6 Arm=p Band=21.3 LocusSupplementaryData=protein Name=tenascin XA… …   Wikipedia

  • tenascin — (= myotendinous antigen; cytotactin) Protein of the extracellular matrix (240 kD subunit: usually as a hexabrachion, a six armed hexamer of more than 1000 kD) selectively present in mesenchyme surrounding foetal (but not adult) rat mammary glands …   Dictionary of molecular biology

  • tenascin — noun Any of a class of glycoprotein found in the extracellular matrix of developing vertebrate embryos …   Wiktionary

  • tenascin — A protein that is present in the mesenchyme that surrounds epithelia in organs undergoing development in embryos; believed to participate in inducing differentiation of epithelia. * * * ten·as·cin (ten asґin) any of a family of at least three… …   Medical dictionary

  • TNR (gene) — Tenascin R (restrictin, janusin), also known as TNR, is a human gene.cite web | title = Entrez Gene: TNR tenascin R (restrictin, janusin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=7143| accessdate = ] …   Wikipedia

  • ITGA8 — Integrin, alpha 8, also known as ITGA8, is a human gene.cite web | title = Entrez Gene: ITGA8 integrin, alpha 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=8516| accessdate = ] PBB Summary section title …   Wikipedia

  • Metastatic breast cancer — is a stage of breast cancer where the disease has spread to distant metastases. It is a complication of primary breast cancer, usually occurring several years after resection of the primary breast cancer. Metastatic breast cancer cells frequently …   Wikipedia

  • Sodium channel — Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell s plasma membrane.[1][2] They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage… …   Wikipedia

  • Collagen, type XIV, alpha 1 — Identifiers Symbols COL14A1; UND External IDs OMIM:& …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”