Laminin, alpha 3

Laminin, alpha 3

Laminin, alpha 3, also known as LAMA3, is a human gene.cite web | title = Entrez Gene: LAMA3 laminin, alpha 3| url =| accessdate = ]

section_title =
summary_text = Laminins are basement membrane components thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. The protein encoded by this gene is the alpha-3 chain of laminin 5, which is a complex glycoprotein composed of three subunits (alpha, beta, and gamma). Laminin 5 is thought to be involved in cell adhesion, signal transduction and differentiation of keratinocytes. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa. Alternatively spliced transcript variants encoding different isoforms have been identified.cite web | title = Entrez Gene: LAMA3 laminin, alpha 3| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Timpl R |title=Macromolecular organization of basement membranes. |journal=Curr. Opin. Cell Biol. |volume=8 |issue= 5 |pages= 618–24 |year= 1997 |pmid= 8939648 |doi=
*cite journal | author=Kivirikko S, McGrath JA, Baudoin C, "et al." |title=A homozygous nonsense mutation in the alpha 3 chain gene of laminin 5 (LAMA3) in lethal (Herlitz) junctional epidermolysis bullosa. |journal=Hum. Mol. Genet. |volume=4 |issue= 5 |pages= 959–62 |year= 1995 |pmid= 7633458 |doi=
*cite journal | author=Rousselle P, Golbik R, van der Rest M, Aumailley M |title=Structural requirement for cell adhesion to kalinin (laminin-5). |journal=J. Biol. Chem. |volume=270 |issue= 23 |pages= 13766–70 |year= 1995 |pmid= 7775432 |doi=
*cite journal | author=Burgeson RE, Chiquet M, Deutzmann R, "et al." |title=A new nomenclature for the laminins. |journal=Matrix Biol. |volume=14 |issue= 3 |pages= 209–11 |year= 1994 |pmid= 7921537 |doi=
*cite journal | author=Ryan MC, Tizard R, VanDevanter DR, Carter WG |title=Cloning of the LamA3 gene encoding the alpha 3 chain of the adhesive ligand epiligrin. Expression in wound repair. |journal=J. Biol. Chem. |volume=269 |issue= 36 |pages= 22779–87 |year= 1994 |pmid= 8077230 |doi=
*cite journal | author=Vidal F, Baudoin C, Miquel C, "et al." |title=Cloning of the laminin alpha 3 chain gene (LAMA3) and identification of a homozygous deletion in a patient with Herlitz junctional epidermolysis bullosa. |journal=Genomics |volume=30 |issue= 2 |pages= 273–80 |year= 1996 |pmid= 8586427 |doi= 10.1006/geno.1995.9877
*cite journal | author=McGrath JA, Kivirikko S, Ciatti S, "et al." |title=A recurrent homozygous nonsense mutation within the LAMA3 gene as a cause of Herlitz junctional epidermolysis bullosa in patients of Pakistani ancestry: evidence for a founder effect. |journal=J. Invest. Dermatol. |volume=106 |issue= 4 |pages= 781–4 |year= 1996 |pmid= 8618022 |doi=
*cite journal | author=Mizushima H, Miyagi Y, Kikkawa Y, "et al." |title=Differential expression of laminin-5/ladsin subunits in human tissues and cancer cell lines and their induction by tumor promoter and growth factors. |journal=J. Biochem. |volume=120 |issue= 6 |pages= 1196–202 |year= 1997 |pmid= 9010770 |doi=
*cite journal | author=Miner JH, Patton BL, Lentz SI, "et al." |title=The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform. |journal=J. Cell Biol. |volume=137 |issue= 3 |pages= 685–701 |year= 1997 |pmid= 9151674 |doi=
*cite journal | author=Doliana R, Bellina I, Bucciotti F, "et al." |title=The human alpha3b is a 'full-sized' laminin chain variant with a more widespread tissue expression than the truncated alpha3a. |journal=FEBS Lett. |volume=417 |issue= 1 |pages= 65–70 |year= 1998 |pmid= 9395076 |doi=
*cite journal | author=Mrowiec T, Melchar C, Górski A |title=HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium. |journal=Arch. Immunol. Ther. Exp. (Warsz.) |volume=45 |issue= 2-3 |pages= 255–9 |year= 1998 |pmid= 9597096 |doi=
*cite journal | author=Pulkkinen L, Cserhalmi-Friedman PB, Tang M, "et al." |title=Molecular analysis of the human laminin alpha3a chain gene (LAMA3a): a strategy for mutation identification and DNA-based prenatal diagnosis in Herlitz junctional epidermolysis bullosa. |journal=Lab. Invest. |volume=78 |issue= 9 |pages= 1067–76 |year= 1998 |pmid= 9759651 |doi=
*cite journal | author=Gonzales M, Haan K, Baker SE, "et al." |title=A cell signal pathway involving laminin-5, alpha3beta1 integrin, and mitogen-activated protein kinase can regulate epithelial cell proliferation. |journal=Mol. Biol. Cell |volume=10 |issue= 2 |pages= 259–70 |year= 1999 |pmid= 9950675 |doi=
*cite journal | author=Hirosaki T, Mizushima H, Tsubota Y, "et al." |title=Structural requirement of carboxyl-terminal globular domains of laminin alpha 3 chain for promotion of rapid cell adhesion and migration by laminin-5. |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22495–502 |year= 2000 |pmid= 10801807 |doi= 10.1074/jbc.M001326200
*cite journal | author=Amano S, Scott IC, Takahara K, "et al." |title=Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 gamma 2 chain. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 22728–35 |year= 2000 |pmid= 10806203 |doi= 10.1074/jbc.M002345200
*cite journal | author=Goldfinger LE, Jiang L, Hopkinson SB, "et al." |title=Spatial regulation and activity modulation of plasmin by high affinity binding to the G domain of the alpha 3 subunit of laminin-5. |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 34887–93 |year= 2001 |pmid= 10956663 |doi= 10.1074/jbc.M006652200
*cite journal | author=Fujiwara H, Kikkawa Y, Sanzen N, Sekiguchi K |title=Purification and characterization of human laminin-8. Laminin-8 stimulates cell adhesion and migration through alpha3beta1 and alpha6beta1 integrins. |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 17550–8 |year= 2001 |pmid= 11278628 |doi= 10.1074/jbc.M010155200
*cite journal | author=McArthur CP, Wang Y, Heruth D, Gustafson S |title=Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53. |journal=Arch. Oral Biol. |volume=46 |issue= 6 |pages= 545–55 |year= 2001 |pmid= 11311202 |doi=
*cite journal | author=Utani A, Nomizu M, Matsuura H, "et al." |title=A unique sequence of the laminin alpha 3 G domain binds to heparin and promotes cell adhesion through syndecan-2 and -4. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 28779–88 |year= 2001 |pmid= 11373281 |doi= 10.1074/jbc.M101420200

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