Laminin, alpha 2

Laminin, alpha 2
Laminin, alpha 2
Identifiers
Symbols LAMA2; LAMM
External IDs OMIM156225 MGI99912 HomoloGene37306 GeneCards: LAMA2 Gene
RNA expression pattern
PBB GE LAMA2 205116 at tn.png
PBB GE LAMA2 213519 s at tn.png
PBB GE LAMA2 216840 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3908 16773
Ensembl ENSG00000196569 ENSMUSG00000019899
UniProt P24043 Q8C9J2
RefSeq (mRNA) NM_000426.3 NM_008481.2
RefSeq (protein) NP_000417.2 NP_032507.2
Location (UCSC) Chr 6:
129.2 – 129.84 Mb
Chr 10:
26.7 – 27.34 Mb
PubMed search [1] [2]

Laminin subunit alpha-2 is a protein that in humans is encoded by the LAMA2 gene.[1][2][3]

Contents

Function

Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene.[3]

References

Further reading

External Links


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  • Laminin, alpha 3 — Laminin, alpha 3, also known as LAMA3, is a human gene.cite web | title = Entrez Gene: LAMA3 laminin, alpha 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=3909| accessdate = ] PBB Summary section title …   Wikipedia

  • Laminin, alpha 5 — Laminin, alpha 5, also known as LAMA5, is a human gene.cite web | title = Entrez Gene: LAMA5 laminin, alpha 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=3911| accessdate = ] PBB Summary section title …   Wikipedia

  • Laminin, alpha 1 — Laminin, alpha 1, also known as LAMA1, is a human gene.cite web | title = Entrez Gene: LAMA1 laminin, alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=284217| accessdate = ] PBB Summary section title …   Wikipedia

  • Laminin, gamma 1 — (formerly LAMB2), also known as LAMC1, is a human gene.cite web | title = Entrez Gene: LAMC1 laminin, gamma 1 (formerly LAMB2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=3915| accessdate = ] PBB… …   Wikipedia

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  • Laminin, beta 2 — (laminin S), also known as LAMB2, is a human gene.cite web | title = Entrez Gene: LAMB2 laminin, beta 2 (laminin S)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=3913| accessdate = ] PBB Summary section… …   Wikipedia

  • Laminin, gamma 2 — Laminin, gamma 2, also known as LAMC2, is a human gene.cite web | title = Entrez Gene: LAMC2 laminin, gamma 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=3918| accessdate = ] PBB Summary section title …   Wikipedia

  • Laminin — is the major non collagenous component of the basal lamina, such as those on which cells of an epithelium sit.cite book |author=M. A. Haralson and John R. Hassell |title=Extracellular matrix: a practical approach |publisher=IRL Press… …   Wikipedia

  • Laminin, beta 3 — Laminin, beta 3, also known as LAMB3, is a human gene.cite web | title = Entrez Gene: LAMB3 laminin, beta 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=3914| accessdate = ] PBB Summary section title =… …   Wikipedia

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