Collagen, type VIII, alpha 1

Collagen, type VIII, alpha 1
Collagen, type VIII, alpha 1

PDB rendering based on 1o91.
Symbols COL8A1; C3orf7; MGC9568
External IDs OMIM120251 MGI88463 HomoloGene22423 GeneCards: COL8A1 Gene
RNA expression pattern
PBB GE COL8A1 221152 at tn.png
More reference expression data
Species Human Mouse
Entrez 1295 12837
Ensembl ENSG00000144810 ENSMUSG00000068196
UniProt P27658 Q3TWU7
RefSeq (mRNA) NM_001850.3 NM_007739.2
RefSeq (protein) NP_001841.2 NP_031765.2
Location (UCSC) Chr 3:
99.36 – 99.52 Mb
Chr 16:
57.62 – 57.75 Mb
PubMed search [1] [2]

Collagen alpha-1(VIII) chain is a protein that in humans is encoded by the COL8A1 gene.[1][2]

This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the same isoform have been observed.[2]


  1. ^ Muragaki Y, Mattei MG, Yamaguchi N, Olsen BR, Ninomiya Y (Jun 1991). "The complete primary structure of the human alpha 1 (VIII) chain and assignment of its gene (COL8A1) to chromosome 3". Eur J Biochem 197 (3): 615–22. doi:10.1111/j.1432-1033.1991.tb15951.x. PMID 2029894. 
  2. ^ a b "Entrez Gene: COL8A1 collagen, type VIII, alpha 1". 

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