Collagen, type XV, alpha 1

Collagen, type XV, alpha 1
Collagen, type XV, alpha 1
Symbols COL15A1; FLJ38566
External IDs OMIM120325 MGI88449 HomoloGene1396 GeneCards: COL15A1 Gene
RNA expression pattern
PBB GE COL15A1 203477 at tn.png
More reference expression data
Species Human Mouse
Entrez 1306 12819
Ensembl ENSG00000204291 ENSMUSG00000028339
UniProt P39059 Q3UZ71
RefSeq (mRNA) NM_001855 NM_009928.3
RefSeq (protein) NP_001846 NP_034058.2
Location (UCSC) Chr 9:
101.71 – 101.83 Mb
Chr 4:
47.22 – 47.33 Mb
PubMed search [1] [2]

Collagen alpha-1(XV) chain is a protein that in humans is encoded by the COL15A1 gene.[1][2]

This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration.[2]


  1. ^ Huebner K, Cannizzaro LA, Jabs EW, Kivirikko S, Manzone H, Pihlajaniemi T, Myers JC (Dec 1992). "Chromosomal assignment of a gene encoding a new collagen type (COL15A1) to 9q21 --> q22". Genomics 14 (2): 220–4. doi:10.1016/S0888-7543(05)80209-5. PMID 1427836. 
  2. ^ a b "Entrez Gene: COL15A1 collagen, type XV, alpha 1". 

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