COL4A6

Collagen, type IV, alpha 6, also known as COL4A6, is a human gene.cite web | title = Entrez Gene: COL4A6 collagen, type IV, alpha 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1288| accessdate = ]

PBB_Summary
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summary_text = This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Two splice variants have been identified for this gene.cite web | title = Entrez Gene: COL4A6 collagen, type IV, alpha 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1288| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ständer M, Naumann U, Wick W, Weller M |title=Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth. |journal=Cell Tissue Res. |volume=296 |issue= 2 |pages= 221–7 |year= 1999 |pmid= 10382266 |doi=
*cite journal | author=Kurpakus Wheater M, Kernacki KA, Hazlett LD |title=Corneal cell proteins and ocular surface pathology. |journal=Biotechnic & histochemistry : official publication of the Biological Stain Commission |volume=74 |issue= 3 |pages= 146–59 |year= 1999 |pmid= 10416788 |doi=
*cite journal | author=Ghebrehiwet B, Peerschke EI, Hong Y, "et al." |title=Short amino acid sequences derived from C1q receptor (C1q-R) show homology with the alpha chains of fibronectin and vitronectin receptors and collagen type IV. |journal=J. Leukoc. Biol. |volume=51 |issue= 6 |pages= 546–56 |year= 1992 |pmid= 1377218 |doi=
*cite journal | author=Gupta S, Batchu RB, Datta K |title=Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface. |journal=Eur. J. Cell Biol. |volume=56 |issue= 1 |pages= 58–67 |year= 1992 |pmid= 1724753 |doi=
*cite journal | author=Hernandez MR, Igoe F, Neufeld AH |title=Extracellular matrix of the human optic nerve head. |journal=Am. J. Ophthalmol. |volume=102 |issue= 2 |pages= 139–48 |year= 1986 |pmid= 2426947 |doi=
*cite journal | author=Glant TT, Hadházy C, Mikecz K, Sipos A |title=Appearance and persistence of fibronectin in cartilage. Specific interaction of fibronectin with collagen type II. |journal=Histochemistry |volume=82 |issue= 2 |pages= 149–58 |year= 1985 |pmid= 3997552 |doi=
*cite journal | author=Matsubara T, Trüeb B, Fehr K, "et al." |title=The localization and secretion of type IV collagen in synovial capillaries by immunohistochemistry using a monoclonal antibody against human type IV collagen. |journal=Exp. Cell Biol. |volume=52 |issue= 3 |pages= 159–69 |year= 1984 |pmid= 6386565 |doi=
*cite journal | author=Uscanga L, Kennedy RH, Stocker S, "et al." |title=Immunolocalization of collagen types, laminin and fibronectin in the normal human pancreas. |journal=Digestion |volume=30 |issue= 3 |pages= 158–64 |year= 1984 |pmid= 6389236 |doi=
*cite journal | author=Sundarraj N, Willson J |title=Monoclonal antibody to human basement membrane collagen type IV. |journal=Immunology |volume=47 |issue= 1 |pages= 133–40 |year= 1982 |pmid= 6811420 |doi=
*cite journal | author=Hahn E, Wick G, Pencev D, Timpl R |title=Distribution of basement membrane proteins in normal and fibrotic human liver: collagen type IV, laminin, and fibronectin. |journal=Gut |volume=21 |issue= 1 |pages= 63–71 |year= 1980 |pmid= 6988303 |doi=
*cite journal | author=Sasaki T, Göhring W, Pan TC, "et al." |title=Binding of mouse and human fibulin-2 to extracellular matrix ligands. |journal=J. Mol. Biol. |volume=254 |issue= 5 |pages= 892–9 |year= 1996 |pmid= 7500359 |doi= 10.1006/jmbi.1995.0664
*cite journal | author=Oohashi T, Ueki Y, Sugimoto M, Ninomiya Y |title=Isolation and structure of the COL4A6 gene encoding the human alpha 6(IV) collagen chain and comparison with other type IV collagen genes. |journal=J. Biol. Chem. |volume=270 |issue= 45 |pages= 26863–7 |year= 1995 |pmid= 7592929 |doi=
*cite journal | author=Sugimoto M, Oohashi T, Ninomiya Y |title=The genes COL4A5 and COL4A6, coding for basement membrane collagen chains alpha 5(IV) and alpha 6(IV), are located head-to-head in close proximity on human chromosome Xq22 and COL4A6 is transcribed from two alternative promoters. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 24 |pages= 11679–83 |year= 1994 |pmid= 7972123 |doi=
*cite journal | author=Donovan FM, Vaughan PJ, Cunningham DD |title=Regulation of protease nexin-1 target protease specificity by collagen type IV. |journal=J. Biol. Chem. |volume=269 |issue= 25 |pages= 17199–205 |year= 1994 |pmid= 8006028 |doi=
*cite journal | author=Oohashi T, Sugimoto M, Mattei MG, Ninomiya Y |title=Identification of a new collagen IV chain, alpha 6(IV), by cDNA isolation and assignment of the gene to chromosome Xq22, which is the same locus for COL4A5. |journal=J. Biol. Chem. |volume=269 |issue= 10 |pages= 7520–6 |year= 1994 |pmid= 8125972 |doi=
*cite journal | author=Zhou J, Ding M, Zhao Z, Reeders ST |title=Complete primary structure of the sixth chain of human basement membrane collagen, alpha 6(IV). Isolation of the cDNAs for alpha 6(IV) and comparison with five other type IV collagen chains. |journal=J. Biol. Chem. |volume=269 |issue= 18 |pages= 13193–9 |year= 1994 |pmid= 8175748 |doi=
*cite journal | author=Zhou J, Mochizuki T, Smeets H, "et al." |title=Deletion of the paired alpha 5(IV) and alpha 6(IV) collagen genes in inherited smooth muscle tumors. |journal=Science |volume=261 |issue= 5125 |pages= 1167–9 |year= 1993 |pmid= 8356449 |doi=
*cite journal | author=Zhang X, Zhou J, Reeders ST, Tryggvason K |title=Structure of the human type IV collagen COL4A6 gene, which is mutated in Alport syndrome-associated leiomyomatosis. |journal=Genomics |volume=33 |issue= 3 |pages= 473–9 |year= 1996 |pmid= 8661006 |doi= 10.1006/geno.1996.0222
*cite journal | author=Cáceres J, Brandan E |title=Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans. |journal=J. Cell. Biochem. |volume=65 |issue= 2 |pages= 145–58 |year= 1997 |pmid= 9136074 |doi=
*cite journal | author=Knott JC, Mahesparan R, Garcia-Cabrera I, "et al." |title=Stimulation of extracellular matrix components in the normal brain by invading glioma cells. |journal=Int. J. Cancer |volume=75 |issue= 6 |pages= 864–72 |year= 1998 |pmid= 9506531 |doi=

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