Collagen, type IV, alpha 6, also known as COL4A6, is a human gene.cite web | title = Entrez Gene: COL4A6 collagen, type IV, alpha 6| url =| accessdate = ]

section_title =
summary_text = This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Two splice variants have been identified for this gene.cite web | title = Entrez Gene: COL4A6 collagen, type IV, alpha 6| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Ständer M, Naumann U, Wick W, Weller M |title=Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth. |journal=Cell Tissue Res. |volume=296 |issue= 2 |pages= 221–7 |year= 1999 |pmid= 10382266 |doi=
*cite journal | author=Kurpakus Wheater M, Kernacki KA, Hazlett LD |title=Corneal cell proteins and ocular surface pathology. |journal=Biotechnic & histochemistry : official publication of the Biological Stain Commission |volume=74 |issue= 3 |pages= 146–59 |year= 1999 |pmid= 10416788 |doi=
*cite journal | author=Ghebrehiwet B, Peerschke EI, Hong Y, "et al." |title=Short amino acid sequences derived from C1q receptor (C1q-R) show homology with the alpha chains of fibronectin and vitronectin receptors and collagen type IV. |journal=J. Leukoc. Biol. |volume=51 |issue= 6 |pages= 546–56 |year= 1992 |pmid= 1377218 |doi=
*cite journal | author=Gupta S, Batchu RB, Datta K |title=Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface. |journal=Eur. J. Cell Biol. |volume=56 |issue= 1 |pages= 58–67 |year= 1992 |pmid= 1724753 |doi=
*cite journal | author=Hernandez MR, Igoe F, Neufeld AH |title=Extracellular matrix of the human optic nerve head. |journal=Am. J. Ophthalmol. |volume=102 |issue= 2 |pages= 139–48 |year= 1986 |pmid= 2426947 |doi=
*cite journal | author=Glant TT, Hadházy C, Mikecz K, Sipos A |title=Appearance and persistence of fibronectin in cartilage. Specific interaction of fibronectin with collagen type II. |journal=Histochemistry |volume=82 |issue= 2 |pages= 149–58 |year= 1985 |pmid= 3997552 |doi=
*cite journal | author=Matsubara T, Trüeb B, Fehr K, "et al." |title=The localization and secretion of type IV collagen in synovial capillaries by immunohistochemistry using a monoclonal antibody against human type IV collagen. |journal=Exp. Cell Biol. |volume=52 |issue= 3 |pages= 159–69 |year= 1984 |pmid= 6386565 |doi=
*cite journal | author=Uscanga L, Kennedy RH, Stocker S, "et al." |title=Immunolocalization of collagen types, laminin and fibronectin in the normal human pancreas. |journal=Digestion |volume=30 |issue= 3 |pages= 158–64 |year= 1984 |pmid= 6389236 |doi=
*cite journal | author=Sundarraj N, Willson J |title=Monoclonal antibody to human basement membrane collagen type IV. |journal=Immunology |volume=47 |issue= 1 |pages= 133–40 |year= 1982 |pmid= 6811420 |doi=
*cite journal | author=Hahn E, Wick G, Pencev D, Timpl R |title=Distribution of basement membrane proteins in normal and fibrotic human liver: collagen type IV, laminin, and fibronectin. |journal=Gut |volume=21 |issue= 1 |pages= 63–71 |year= 1980 |pmid= 6988303 |doi=
*cite journal | author=Sasaki T, Göhring W, Pan TC, "et al." |title=Binding of mouse and human fibulin-2 to extracellular matrix ligands. |journal=J. Mol. Biol. |volume=254 |issue= 5 |pages= 892–9 |year= 1996 |pmid= 7500359 |doi= 10.1006/jmbi.1995.0664
*cite journal | author=Oohashi T, Ueki Y, Sugimoto M, Ninomiya Y |title=Isolation and structure of the COL4A6 gene encoding the human alpha 6(IV) collagen chain and comparison with other type IV collagen genes. |journal=J. Biol. Chem. |volume=270 |issue= 45 |pages= 26863–7 |year= 1995 |pmid= 7592929 |doi=
*cite journal | author=Sugimoto M, Oohashi T, Ninomiya Y |title=The genes COL4A5 and COL4A6, coding for basement membrane collagen chains alpha 5(IV) and alpha 6(IV), are located head-to-head in close proximity on human chromosome Xq22 and COL4A6 is transcribed from two alternative promoters. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 24 |pages= 11679–83 |year= 1994 |pmid= 7972123 |doi=
*cite journal | author=Donovan FM, Vaughan PJ, Cunningham DD |title=Regulation of protease nexin-1 target protease specificity by collagen type IV. |journal=J. Biol. Chem. |volume=269 |issue= 25 |pages= 17199–205 |year= 1994 |pmid= 8006028 |doi=
*cite journal | author=Oohashi T, Sugimoto M, Mattei MG, Ninomiya Y |title=Identification of a new collagen IV chain, alpha 6(IV), by cDNA isolation and assignment of the gene to chromosome Xq22, which is the same locus for COL4A5. |journal=J. Biol. Chem. |volume=269 |issue= 10 |pages= 7520–6 |year= 1994 |pmid= 8125972 |doi=
*cite journal | author=Zhou J, Ding M, Zhao Z, Reeders ST |title=Complete primary structure of the sixth chain of human basement membrane collagen, alpha 6(IV). Isolation of the cDNAs for alpha 6(IV) and comparison with five other type IV collagen chains. |journal=J. Biol. Chem. |volume=269 |issue= 18 |pages= 13193–9 |year= 1994 |pmid= 8175748 |doi=
*cite journal | author=Zhou J, Mochizuki T, Smeets H, "et al." |title=Deletion of the paired alpha 5(IV) and alpha 6(IV) collagen genes in inherited smooth muscle tumors. |journal=Science |volume=261 |issue= 5125 |pages= 1167–9 |year= 1993 |pmid= 8356449 |doi=
*cite journal | author=Zhang X, Zhou J, Reeders ST, Tryggvason K |title=Structure of the human type IV collagen COL4A6 gene, which is mutated in Alport syndrome-associated leiomyomatosis. |journal=Genomics |volume=33 |issue= 3 |pages= 473–9 |year= 1996 |pmid= 8661006 |doi= 10.1006/geno.1996.0222
*cite journal | author=Cáceres J, Brandan E |title=Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans. |journal=J. Cell. Biochem. |volume=65 |issue= 2 |pages= 145–58 |year= 1997 |pmid= 9136074 |doi=
*cite journal | author=Knott JC, Mahesparan R, Garcia-Cabrera I, "et al." |title=Stimulation of extracellular matrix components in the normal brain by invading glioma cells. |journal=Int. J. Cancer |volume=75 |issue= 6 |pages= 864–72 |year= 1998 |pmid= 9506531 |doi=

update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes

Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Collagen — Tropocollagen triple helix Collagen /ˈkɒlədʒɨn/ is a group of naturally occurring proteins found in animals, especially in the flesh and connective tissues of mammals.[1] It is the main component of connectiv …   Wikipedia

  • Type-IV collagen — is a type of collagen found primarily in the basal lamina. The type IV collagen C4 domain at the C terminus is not removed in post translational processing, and the fibers link head to head, rather than in parallel. Also, type IV lacks the… …   Wikipedia

  • Keratin — Not to be confused with kerogen, carotene, chitin, or creatine. Microscopy of keratin filaments inside cells. Keratin refers to a family of fibrous structural proteins. Keratin is the key structural material making up the outer layer of human… …   Wikipedia

  • Extracellular matrix — Illustration depicting extracellular matrix (basement membrane and interstitial matrix) in relation to epithelium, endothelium and connective tissue Latin …   Wikipedia

  • Cytokeratin — Keratin intermediate filaments in epithelial cells (red stain). Cytokeratins are proteins of keratin containing intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. The term cytokeratin began to be used in the… …   Wikipedia

  • Decorin — PDB rendering based on 1xcd …   Wikipedia

  • Type-II collagen — collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) Identifiers Symbol COL2A1 Alt. symbols SEDC Entrez …   Wikipedia

  • Type-I collagen — collagen, type I, alpha 1 Identifiers Symbol COL1A1 Entrez 1277 HUGO …   Wikipedia

  • COL1A2 — Collagen, type I, alpha 2 Identifiers Symbols COL1A2; OI4 External IDs OMIM: …   Wikipedia

  • Matrix gla protein — Identifiers Symbols MGP; MGLAP; NTI External IDs OMIM:  …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”