Type-IV collagen

Type-IV collagen is a type of collagen found primarily in the basal lamina. The type IV collagen C4 domain at the C-terminus is not removed in post-translational processing, and the fibers link head-to-head, rather than in parallel. Also, type-IV lacks the regular glycine in every third residue necessary for the tight, collagen helix. This makes the overall arrangement more sloppy with kinks. These two features cause the collagen to form in a sheet, the form of the basal lamina

There are six human genes associated with it:^[1]

• COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6

Clinical significance

The alpha 3 protein constituent of type-IV collagen is thought to be the antigen implicated in Goodpasture's syndrome, wherein the immune system attacks the basement membranes of the glomeruli and the alveoli.

Mutations to the genes coding for type-IV collagen lead to Alport syndrome.

References

1. ^ Khoshnoodi J, Pedchenko V, Hudson BG (May 2008). "Mammalian collagen IV". Microsc. Res. Tech. 71 (5): 357–70. doi:10.1002/jemt.20564. PMID 18219669. 

External links

• MeSH Collagen+type+IV

This protein-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Collagens Protein stubs Wikimedia Foundation. 2010. Игры ⚽ Нужен реферат? Kappa Ophiuchi Lakewood Cultural Center Look at other dictionaries: Type-II collagen — collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) Identifiers Symbol COL2A1 Alt. symbols SEDC Entrez …   Wikipedia Type-I collagen — collagen, type I, alpha 1 Identifiers Symbol COL1A1 Entrez 1277 HUGO …   Wikipedia Type-III collagen — Collagen, type III, alpha 1 (Ehlers Danlos syndrome type IV, autosomal dominant), also known as COL3A1, is a human gene. PBB Summary section title = summary text = This gene encodes a fibrillar collagen that is found in extensible connective… …   Wikipedia Type-V collagen — is a form of fibrillar [cite journal |author=Wenstrup RJ, Florer JB, Brunskill EW, Bell SM, Chervoneva I, Birk DE |title=Type V collagen controls the initiation of collagen fibril assembly |journal=J. Biol. Chem. |volume=279 |issue=51… …   Wikipedia Type XXVII collagen — is the protein predicted to be encoded by COL27A1. It was first described by Dr. James M. Pace and his colleagues at the University of Washington. It is related to the fibrillar collagens: type II, type XI, and type XXIV. Current research… …   Wikipedia Type XVIII collagen — protein Name=collagen, type XVIII, alpha 1 caption= width= HGNCid=2195 Symbol=COL18A1 AltSymbols= EntrezGene=80781 OMIM=120328 RefSeq=NM 130445 UniProt=P39060 PDB= ECnumber= Chromosome=21 Arm=q Band=22.3 LocusSupplementaryData=Type XVIII collagen …   Wikipedia Cross-linked N-telopeptide of type I collagen — Cross linked N telopeptides of type I collagen (NTX or NTx) are a specific breakdown product of the type I collagen found in bone cartilage, used as a marker of bone turnover. NTx is measured in the urine or serum.Urine NTX levels of greater than …   Wikipedia Collagen, type II, alpha 1 — (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) Identifiers Symbol COL2A1 Alt. symbols SEDC Entrez …   Wikipedia Collagen, type I, alpha 1 — PDB rendering based on 1y0f …   Wikipedia Collagen, type V, alpha 1 — Rendering based on PDB 1A89 …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”