Cartilage oligomeric matrix protein

Cartilage oligomeric matrix protein, also known as COMP, is a human gene.cite web | title = Entrez Gene: COMP cartilage oligomeric matrix protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1311| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein.cite journal | author = Paulsson M, Heinegård D | title = Purification and structural characterization of a cartilage matrix protein | journal = Biochem. J. | volume = 197 | issue = 2 | pages = 367–75 | year = 1981 | pmid = 7325960 | doi = | issn = | url = http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=7325960 ] It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfide bonds. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).cite web | title = Entrez Gene: COMP cartilage oligomeric matrix protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1311| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Unger S, Hecht JT |title=Pseudoachondroplasia and multiple epiphyseal dysplasia: New etiologic developments. |journal=Am. J. Med. Genet. |volume=106 |issue= 4 |pages= 244–50 |year= 2002 |pmid= 11891674 |doi=
*cite journal | author=Liu C |title=Transcriptional mechanism of COMP gene expression and chondrogenesis. |journal=Journal of musculoskeletal & neuronal interactions |volume=5 |issue= 4 |pages= 340–1 |year= 2006 |pmid= 16340129 |doi=
*cite journal | author=Morozzi G, Fabbroni M, Bellisai F, "et al." |title=Cartilage oligomeric matrix protein level in rheumatic diseases: potential use as a marker for measuring articular cartilage damage and/or the therapeutic efficacy of treatments. |journal=Ann. N. Y. Acad. Sci. |volume=1108 |issue= |pages= 398–407 |year= 2007 |pmid= 17894003 |doi=
*cite journal | author=Månsson B, Carey D, Alini M, "et al." |title=Cartilage and bone metabolism in rheumatoid arthritis. Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism. |journal=J. Clin. Invest. |volume=95 |issue= 3 |pages= 1071–7 |year= 1995 |pmid= 7533784 |doi=
*cite journal | author=Hecht JT, Nelson LD, Crowder E, "et al." |title=Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia. |journal=Nat. Genet. |volume=10 |issue= 3 |pages= 325–9 |year= 1995 |pmid= 7670471 |doi= 10.1038/ng0795-325
*cite journal | author=Briggs MD, Hoffman SM, King LM, "et al." |title=Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene. |journal=Nat. Genet. |volume=10 |issue= 3 |pages= 330–6 |year= 1995 |pmid= 7670472 |doi= 10.1038/ng0795-330
*cite journal | author=Newton G, Weremowicz S, Morton CC, "et al." |title=Characterization of human and mouse cartilage oligomeric matrix protein. |journal=Genomics |volume=24 |issue= 3 |pages= 435–9 |year= 1995 |pmid= 7713493 |doi= 10.1006/geno.1994.1649
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Oehlmann R, Summerville GP, Yeh G, "et al." |title=Genetic linkage mapping of multiple epiphyseal dysplasia to the pericentromeric region of chromosome 19. |journal=Am. J. Hum. Genet. |volume=54 |issue= 1 |pages= 3–10 |year= 1994 |pmid= 8279467 |doi=
*cite journal | author=Briggs MD, Rasmussen IM, Weber JL, "et al." |title=Genetic linkage of mild pseudoachondroplasia (PSACH) to markers in the pericentromeric region of chromosome 19. |journal=Genomics |volume=18 |issue= 3 |pages= 656–60 |year= 1994 |pmid= 8307576 |doi=
*cite journal | author=Ballo R, Briggs MD, Cohn DH, "et al." |title=Multiple epiphyseal dysplasia, ribbing type: a novel point mutation in the COMP gene in a South African family. |journal=Am. J. Med. Genet. |volume=68 |issue= 4 |pages= 396–400 |year= 1997 |pmid= 9021009 |doi=
*cite journal | author=Susic S, McGrory J, Ahier J, Cole WG |title=Multiple epiphyseal dysplasia and pseudoachondroplasia due to novel mutations in the calmodulin-like repeats of cartilage oligomeric matrix protein. |journal=Clin. Genet. |volume=51 |issue= 4 |pages= 219–24 |year= 1997 |pmid= 9184241 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Briggs MD, Mortier GR, Cole WG, "et al." |title=Diverse mutations in the gene for cartilage oligomeric matrix protein in the pseudoachondroplasia-multiple epiphyseal dysplasia disease spectrum. |journal=Am. J. Hum. Genet. |volume=62 |issue= 2 |pages= 311–9 |year= 1998 |pmid= 9463320 |doi=
*cite journal | author=Rosenberg K, Olsson H, Mörgelin M, Heinegård D |title=Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen. |journal=J. Biol. Chem. |volume=273 |issue= 32 |pages= 20397–403 |year= 1998 |pmid= 9685393 |doi=
*cite journal | author=Hecht JT, Deere M, Putnam E, "et al." |title=Characterization of cartilage oligomeric matrix protein (COMP) in human normal and pseudoachondroplasia musculoskeletal tissues. |journal=Matrix Biol. |volume=17 |issue= 4 |pages= 269–78 |year= 1998 |pmid= 9749943 |doi=
*cite journal | author=Délot E, King LM, Briggs MD, "et al." |title=Trinucleotide expansion mutations in the cartilage oligomeric matrix protein (COMP) gene. |journal=Hum. Mol. Genet. |volume=8 |issue= 1 |pages= 123–8 |year= 1999 |pmid= 9887340 |doi=
*cite journal | author=Ikegawa S, Ohashi H, Nishimura G, "et al." |title=Novel and recurrent COMP (cartilage oligomeric matrix protein) mutations in pseudoachondroplasia and multiple epiphyseal dysplasia. |journal=Hum. Genet. |volume=103 |issue= 6 |pages= 633–8 |year= 1999 |pmid= 9921895 |doi=
*cite journal | author=Deere M, Sanford T, Francomano CA, "et al." |title=Identification of nine novel mutations in cartilage oligomeric matrix protein in patients with pseudoachondroplasia and multiple epiphyseal dysplasia. |journal=Am. J. Med. Genet. |volume=85 |issue= 5 |pages= 486–90 |year= 1999 |pmid= 10405447 |doi=
*cite journal | author=Thur J, Rosenberg K, Nitsche DP, "et al." |title=Mutations in cartilage oligomeric matrix protein causing pseudoachondroplasia and multiple epiphyseal dysplasia affect binding of calcium and collagen I, II, and IX. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6083–92 |year= 2001 |pmid= 11084047 |doi= 10.1074/jbc.M009512200

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes