Collagen, type XXV, alpha 1

Collagen, type XXV, alpha 1
Collagen, type XXV, alpha 1
Symbols COL25A1; CLAC; CLACP
External IDs OMIM610004 MGI1924268 HomoloGene57111 GeneCards: COL25A1 Gene
Species Human Mouse
Entrez 84570 77018
Ensembl ENSG00000188517 ENSMUSG00000058897
UniProt Q9BXS0 Q99MQ5
RefSeq (mRNA) NM_032518.2 NM_029838
RefSeq (protein) NP_115907.2 NP_084114
Location (UCSC) Chr 4:
109.73 – 110.22 Mb
Chr 3:
129.88 – 130.3 Mb
PubMed search [1] [2]

Collagen alpha-1(XXV) chain is a protein that in humans is encoded by the COL25A1 gene.[1][2]

COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC, a soluble form of COL25A1 containing the extracellular collagen domains that associates with senile plaques in Alzheimer disease (AD; MIM 104300) brains (Osada et al., 2005).[supplied by OMIM][2]


Collagen, type XXV, alpha 1 has been shown to interact with Amyloid precursor protein.[1]


Further reading

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