Lysyl hydroxylase

Lysyl hydroxylase

protein
Name = procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1
caption =


width =
HGNCid = 9081
Symbol = PLOD1
AltSymbols = LLH, PLOD
EntrezGene = 5351
OMIM = 153454
RefSeq = NM_000302
UniProt = Q02809
PDB =
ECnumber = 1.14.11.4
Chromosome = 1
Arm = p
Band = 36.3
LocusSupplementaryData = -36.2
protein
Name = procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
caption =


width =
HGNCid = 9082
Symbol = PLOD2
AltSymbols =
EntrezGene = 5352
OMIM = 601865
RefSeq = NM_000935
UniProt = O00469
PDB =
ECnumber =
Chromosome = 3
Arm = q
Band = 24
LocusSupplementaryData =

Lysyl hydroxylase (or procollagen-lysine 5-dioxygenase) is an oxygenase enzyme which catalyzes the hydroxylation of lysine to hydroxylysine. This reaction is involved in the formation and stabilization of collagen.

It requires vitamin C as a cofactor.

Pathology

A deficiency is associated with Ehlers-Danlos syndrome (type 6).

External links

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Look at other dictionaries:

  • lysyl hydroxylase — lysyl hydroxylase. См. лизилгидроксилаза. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • lysyl hydroxylase — ly·syl hy·drox·y·lase (liґsəl hi drokґsə lās) an enzyme of the oxidoreductase class that catalyzes the hydroxylation of specific lysine residues in nascent procollagen chains; the hydroxylysine residues act as sites of attachment… …   Medical dictionary

  • Lysyl oxidase — Lysyl oxidase, also known as LOX, is a human gene.cite web | title = Entrez Gene: LOX lysyl oxidase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=4015| accessdate = ] PBB Summary section title = summary… …   Wikipedia

  • lysyl — The univalent radical of lysine. l. hydroxylase an enzyme that acts on specific l. residues in certain proteins ( E.G., collagens) with α ketoglutarate and O2 to produce δ hydroxylysyl residues, succinate, and CO2; this enzyme, which requires… …   Medical dictionary

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  • лизилгидроксилаза — lysyl hydroxylase лизилгидроксилаза [КФ 1.14.11.4]. Фермент, катализирующий образование оксилизина в составе коллагена <collagen> и некоторых др. белков, сниженная активность Л. известна при некоторых формах синдрома Элерса Данло <Ehlers …   Молекулярная биология и генетика. Толковый словарь.

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