Laminin, alpha 5

Laminin, alpha 5

Laminin, alpha 5, also known as LAMA5, is a human gene.cite web | title = Entrez Gene: LAMA5 laminin, alpha 5| url =| accessdate = ]

section_title =
summary_text = Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined.cite web | title = Entrez Gene: LAMA5 laminin, alpha 5| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Utani A, Nomizu M, Yamada Y |title=Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences. |journal=J. Biol. Chem. |volume=272 |issue= 5 |pages= 2814–20 |year= 1997 |pmid= 9006922 |doi=
*cite journal | author=Rousselle P, Keene DR, Ruggiero F, "et al." |title=Laminin 5 binds the NC-1 domain of type VII collagen. |journal=J. Cell Biol. |volume=138 |issue= 3 |pages= 719–28 |year= 1997 |pmid= 9245798 |doi=
*cite journal | author=Durkin ME, Loechel F, Mattei MG, "et al." |title=Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation. |journal=FEBS Lett. |volume=411 |issue= 2-3 |pages= 296–300 |year= 1997 |pmid= 9271224 |doi=
*cite journal | author=Tiger CF, Champliaud MF, Pedrosa-Domellof F, "et al." |title=Presence of laminin alpha5 chain and lack of laminin alpha1 chain during human muscle development and in muscular dystrophies. |journal=J. Biol. Chem. |volume=272 |issue= 45 |pages= 28590–5 |year= 1997 |pmid= 9353324 |doi=
*cite journal | author=Mrowiec T, Melchar C, Górski A |title=HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium. |journal=Arch. Immunol. Ther. Exp. (Warsz.) |volume=45 |issue= 2-3 |pages= 255–9 |year= 1998 |pmid= 9597096 |doi=
*cite journal | author=Nagase T, Ishikawa K, Miyajima N, "et al." |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31–9 |year= 1998 |pmid= 9628581 |doi=
*cite journal | author=Shimizu H, Hosokawa H, Ninomiya H, "et al." |title=Adhesion of cultured bovine aortic endothelial cells to laminin-1 mediated by dystroglycan. |journal=J. Biol. Chem. |volume=274 |issue= 17 |pages= 11995–2000 |year= 1999 |pmid= 10207021 |doi=
*cite journal | author=Son YJ, Scranton TW, Sunderland WJ, "et al." |title=The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface. |journal=J. Biol. Chem. |volume=275 |issue= 1 |pages= 451–60 |year= 2000 |pmid= 10617638 |doi=
*cite journal | author=Köhler D, Kruse M, Stöcker W, Sterchi EE |title=Heterologously overexpressed, affinity-purified human meprin alpha is functionally active and cleaves components of the basement membrane in vitro. |journal=FEBS Lett. |volume=465 |issue= 1 |pages= 2–7 |year= 2000 |pmid= 10620696 |doi=
*cite journal | author=Kikkawa Y, Sanzen N, Fujiwara H, "et al." |title=Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins. |journal=J. Cell. Sci. |volume=113 ( Pt 5) |issue= |pages= 869–76 |year= 2000 |pmid= 10671376 |doi=
*cite journal | author=Champliaud MF, Virtanen I, Tiger CF, "et al." |title=Posttranslational modifications and beta/gamma chain associations of human laminin alpha1 and laminin alpha5 chains: purification of laminin-3 from placenta. |journal=Exp. Cell Res. |volume=259 |issue= 2 |pages= 326–35 |year= 2000 |pmid= 10964500 |doi= 10.1006/excr.2000.4980
*cite journal | author=Libby RT, Champliaud MF, Claudepierre T, "et al." |title=Laminin expression in adult and developing retinae: evidence of two novel CNS laminins. |journal=J. Neurosci. |volume=20 |issue= 17 |pages= 6517–28 |year= 2000 |pmid= 10964957 |doi=
*cite journal | author=Pierce RA, Griffin GL, Miner JH, Senior RM |title=Expression patterns of laminin alpha1 and alpha5 in human lung during development. |journal=Am. J. Respir. Cell Mol. Biol. |volume=23 |issue= 6 |pages= 742–7 |year= 2001 |pmid= 11104726 |doi=
*cite journal | author=Parsons SF, Lee G, Spring FA, "et al." |title=Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity. |journal=Blood |volume=97 |issue= 1 |pages= 312–20 |year= 2001 |pmid= 11133776 |doi=
*cite journal | author=Saghizadeh M, Brown DJ, Castellon R, "et al." |title=Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and integrin alterations. |journal=Am. J. Pathol. |volume=158 |issue= 2 |pages= 723–34 |year= 2001 |pmid= 11159210 |doi=
*cite journal | author=McArthur CP, Wang Y, Heruth D, Gustafson S |title=Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53. |journal=Arch. Oral Biol. |volume=46 |issue= 6 |pages= 545–55 |year= 2001 |pmid= 11311202 |doi=
*cite journal | author=Gagnoux-Palacios L, Allegra M, Spirito F, "et al." |title=The short arm of the laminin gamma2 chain plays a pivotal role in the incorporation of laminin 5 into the extracellular matrix and in cell adhesion. |journal=J. Cell Biol. |volume=153 |issue= 4 |pages= 835–50 |year= 2001 |pmid= 11352943 |doi=
*cite journal | author=Nagase T, Kikuno R, Ohara O |title=Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. |journal=DNA Res. |volume=8 |issue= 4 |pages= 179–87 |year= 2002 |pmid= 11572484 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Doi M, Thyboll J, Kortesmaa J, "et al." |title=Recombinant human laminin-10 (alpha5beta1gamma1). Production, purification, and migration-promoting activity on vascular endothelial cells. |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 12741–8 |year= 2002 |pmid= 11821406 |doi= 10.1074/jbc.M111228200

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