Glypican 3

Glypican 3, also known as GPC3, is a human gene.cite web | title = Entrez Gene: GPC3 glypican 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2719| accessdate = ] cite journal | author = Jakubovic BD, Jothy S | title = Glypican-3: from the mutations of Simpson-Golabi-Behmel genetic syndrome to a tumor marker for hepatocellular carcinoma | journal = Exp. Mol. Pathol. | volume = 82 | issue = 2 | pages = 184–9 | year = 2007 | month = April | pmid = 17258707 | doi = 10.1016/j.yexmp.2006.10.010 | url = | issn = ] The protein encoded by this gene is a member of the glypican family.

tructure and function

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.

Disease linkage

Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome.cite journal | author = Davoodi J, Kelly J, Gendron NH, MacKenzie AE | title = The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26 | journal = Proteomics | volume = 7 | issue = 13 | pages = 2300–10 | year = 2007 | month = June | pmid = 17549790 | doi = 10.1002/pmic.200600654 | url = | issn = ]

Diagnostic utility

Glypican 3 immunostaining has utility for differentiating hepatocellular carcinoma (HCC) and dysplastic changes in cirrhotic livers; HCC stains with glypican 3, while liver with dysplastic changes and/or cirrhotic changes does not. [cite journal | author=Anatelli F, Chuang ST, Yang XJ, Wang HL. |title=Value of glypican 3 immunostaining in the diagnosis of hepatocellular carcinoma on needle biopsy |journal=Am J Clin Pathol. |volume=130 |issue= 2 |pages= 219-23–8 |year= 2008 |pmid= 18628090 |doi= 10.1309/WMB5PX57Y4P8QCTY ]

ee also

* Glypican

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Li M, Squire JA, Weksberg R |title=Overgrowth syndromes and genomic imprinting: from mouse to man. |journal=Clin. Genet. |volume=53 |issue= 3 |pages= 165–70 |year= 1998 |pmid= 9630066 |doi=
*cite journal | author=Filmus J |title=Glypicans in growth control and cancer. |journal=Glycobiology |volume=11 |issue= 3 |pages= 19R–23R |year= 2001 |pmid= 11320054 |doi=
*cite journal | author=Filmus J, Shi W, Wong ZM, Wong MJ |title=Identification of a new membrane-bound heparan sulphate proteoglycan. |journal=Biochem. J. |volume=311 ( Pt 2) |issue= |pages= 561–5 |year= 1995 |pmid= 7487896 |doi=
*cite journal | author=Watanabe K, Yamada H, Yamaguchi Y |title=K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney. |journal=J. Cell Biol. |volume=130 |issue= 5 |pages= 1207–18 |year= 1995 |pmid= 7657705 |doi=
*cite journal | author=Xuan JY, Besner A, Ireland M, "et al." |title=Mapping of Simpson-Golabi-Behmel syndrome to Xq25-q27. |journal=Hum. Mol. Genet. |volume=3 |issue= 1 |pages= 133–7 |year= 1994 |pmid= 7909248 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Pilia G, Hughes-Benzie RM, MacKenzie A, "et al." |title=Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome. |journal=Nat. Genet. |volume=12 |issue= 3 |pages= 241–7 |year= 1996 |pmid= 8589713 |doi= 10.1038/ng0396-241
*cite journal | author=Shen T, Sonoda G, Hamid J, "et al." |title=Mapping of the Simpson-Golabi-Behmel overgrowth syndrome gene (GPC3) to chromosome X in human and rat by fluorescence in situ hybridization. |journal=Mamm. Genome |volume=8 |issue= 1 |pages= 72 |year= 1997 |pmid= 9021160 |doi=
*cite journal | author=Lage H, Dietel M |title=Cloning and characterization of human cDNAs encoding a protein with high homology to rat intestinal development protein OCI-5. |journal=Gene |volume=188 |issue= 2 |pages= 151–6 |year= 1997 |pmid= 9133586 |doi=
*cite journal | author=Huber R, Crisponi L, Mazzarella R, "et al." |title=Analysis of exon/intron structure and 400 kb of genomic sequence surrounding the 5'-promoter and 3'-terminal ends of the human glypican 3 (GPC3) gene. |journal=Genomics |volume=45 |issue= 1 |pages= 48–58 |year= 1997 |pmid= 9339360 |doi= 10.1006/geno.1997.4916
*cite journal | author=Hsu HC, Cheng W, Lai PL |title=Cloning and expression of a developmentally regulated transcript MXR7 in hepatocellular carcinoma: biological significance and temporospatial distribution. |journal=Cancer Res. |volume=57 |issue= 22 |pages= 5179–84 |year= 1997 |pmid= 9371521 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Veugelers M, Vermeesch J, Watanabe K, "et al." |title=GPC4, the gene for human K-glypican, flanks GPC3 on xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome. |journal=Genomics |volume=53 |issue= 1 |pages= 1–11 |year= 1998 |pmid= 9787072 |doi= 10.1006/geno.1998.5465
*cite journal | author=Pellegrini M, Pilia G, Pantano S, "et al." |title=Gpc3 expression correlates with the phenotype of the Simpson-Golabi-Behmel syndrome. |journal=Dev. Dyn. |volume=213 |issue= 4 |pages= 431–9 |year= 1999 |pmid= 9853964 |doi= 10.1002/(SICI)1097-0177(199812)213:4<431::AID-AJA8>3.0.CO;2-7 |doilabel=10.1002/(SICI)1097-0177(199812)213:4431::AID-AJA83.0.CO;2-7
*cite journal | author=Huber R, Mazzarella R, Chen CN, "et al." |title=Glypican 3 and glypican 4 are juxtaposed in Xq26.1. |journal=Gene |volume=225 |issue= 1-2 |pages= 9–16 |year= 1999 |pmid= 9931407 |doi=
*cite journal | author=Xuan JY, Hughes-Benzie RM, MacKenzie AE |title=A small interstitial deletion in the GPC3 gene causes Simpson-Golabi-Behmel syndrome in a Dutch-Canadian family. |journal=J. Med. Genet. |volume=36 |issue= 1 |pages= 57–8 |year= 1999 |pmid= 9950367 |doi=
*cite journal | author=Veugelers M, Cat BD, Muyldermans SY, "et al." |title=Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene. |journal=Hum. Mol. Genet. |volume=9 |issue= 9 |pages= 1321–8 |year= 2000 |pmid= 10814714 |doi=
*cite journal | author=Khan S, Blackburn M, Mao DL, "et al." |title=Glypican-3 (GPC3) expression in human placenta: localization to the differentiated syncytiotrophoblast. |journal=Histol. Histopathol. |volume=16 |issue= 1 |pages= 71–8 |year= 2001 |pmid= 11193214 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes