- Glypican 4
Glypican 4, also known as GPC4, is a human
gene .cite web | title = Entrez Gene: GPC4 glypican 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2239| accessdate = ]PBB_Summary
section_title =
summary_text = Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.cite web | title = Entrez Gene: GPC4 glypican 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2239| accessdate = ]ee also
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Glypican References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Ross MT, Grafham DV, Coffey AJ, "et al." |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Sheu TJ, Schwarz EM, O'Keefe RJ, "et al." |title=Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae. |journal=J. Bone Miner. Res. |volume=17 |issue= 5 |pages= 915–22 |year= 2002 |pmid= 12009023 |doi=
*cite journal | author=Karumanchi SA, Jha V, Ramchandran R, "et al." |title=Cell surface glypicans are low-affinity endostatin receptors. |journal=Mol. Cell |volume=7 |issue= 4 |pages= 811–22 |year= 2001 |pmid= 11336704 |doi=
*cite journal | author=Hagihara K, Watanabe K, Chun J, Yamaguchi Y |title=Glypican-4 is an FGF2-binding heparan sulfate proteoglycan expressed in neural precursor cells. |journal=Dev. Dyn. |volume=219 |issue= 3 |pages= 353–67 |year= 2000 |pmid= 11066092 |doi= 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1059>3.0.CO;2-# |doilabel=10.1002/1097-0177(2000)9999:9999::AID-DVDY10593.0.CO;2-#
*cite journal | author=Veugelers M, Cat BD, Muyldermans SY, "et al." |title=Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene. |journal=Hum. Mol. Genet. |volume=9 |issue= 9 |pages= 1321–8 |year= 2000 |pmid= 10814714 |doi=
*cite journal | author=Siebertz B, Stöcker G, Drzeniek Z, "et al." |title=Expression of glypican-4 in haematopoietic-progenitor and bone-marrow-stromal cells. |journal=Biochem. J. |volume=344 Pt 3 |issue= |pages= 937–43 |year= 2000 |pmid= 10585884 |doi=
*cite journal | author=Huber R, Mazzarella R, Chen CN, "et al." |title=Glypican 3 and glypican 4 are juxtaposed in Xq26.1. |journal=Gene |volume=225 |issue= 1-2 |pages= 9–16 |year= 1999 |pmid= 9931407 |doi=
*cite journal | author=Veugelers M, Vermeesch J, Watanabe K, "et al." |title=GPC4, the gene for human K-glypican, flanks GPC3 on xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome. |journal=Genomics |volume=53 |issue= 1 |pages= 1–11 |year= 1998 |pmid= 9787072 |doi= 10.1006/geno.1998.5465
*cite journal | author=Watanabe K, Yamada H, Yamaguchi Y |title=K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney. |journal=J. Cell Biol. |volume=130 |issue= 5 |pages= 1207–18 |year= 1995 |pmid= 7657705 |doi=PBB_Controls
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