Glypican 2

Glypican 2
Identifiers
Symbols	GPC2; DKFZp547M109; FLJ38962
External IDs	MGI: 1919201 HomoloGene: 17657 GeneCards: GPC2 Gene
Gene Ontology Molecular function • heparan sulfate proteoglycan binding Cellular component • extracellular region • proteinaceous extracellular matrix • extracellular space • endoplasmic reticulum • plasma membrane • anchored to membrane Biological process • neuron differentiation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	221914	71951
Ensembl	ENSG00000213420	ENSMUSG00000029510
UniProt	Q8N158	A1A5C0
RefSeq (mRNA)	NM_152742	NM_172412.2
RefSeq (protein)	NP_689955	NP_766000.1
Location (UCSC)	Chr 7: 99.77 – 99.77 Mb	Chr 5: 138.71 – 138.72 Mb
PubMed search	[1]	[2]

Glypican 2 (GPC2), also known cerebroglycan, is a protein which in humans is encoded by the GPC2 gene.^[1][2]

Function

Cerebroglycan is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons.^[3] Cerebroglycan has especially high affinity for laminin-1.^[4]

See also

• Glypican

References

1. ^ Stipp CS, Litwack ED, Lander AD (January 1994). "Cerebroglycan: an integral membrane heparan sulfate proteoglycan that is unique to the developing nervous system and expressed specifically during neuronal differentiation". J. Cell Biol. 124 (1–2): 149–160. doi:10.1083/jcb.124.1.149. PMC 2119891. PMID 8294498. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2119891. 
2. ^ "Entrez Gene: GPC2 glypican 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=221914. 
3. ^ Ivins JK, Litwack ED, Kumbasar A, Stipp CS, Lander AD (April 1997). "Cerebroglycan, a developmentally regulated cell-surface heparan sulfate proteoglycan, is expressed on developing axons and growth cones". Dev. Biol. 184 (2): 320–332. doi:10.1006/dbio.1997.8532. PMID 9133438. 
4. ^ Herndon ME, Stipp CS, Lander AD (February 1999). "Interactions of neural glycosaminoglycans and proteoglycans with protein ligands: assessment of selectivity, heterogeneity and the participation of core proteins in binding". Glycobiology 9 (2): 143–155. doi:10.1093/glycob/9.2.143. PMID 9949192. 

External links

• MeSH GPC2+protein,+human

This protein-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Human proteins Protein stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат C6orf89 TMED4 Look at other dictionaries: Glypican 3 — Glypican 3, also known as GPC3, is a human gene.cite web | title = Entrez Gene: GPC3 glypican 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=2719| accessdate = ] cite journal | author = Jakubovic BD,… …   Wikipedia Glypican 1 — Glypican 1, also known as GPC1, is a human gene.cite web | title = Entrez Gene: GPC1 glypican 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=2817| accessdate = ] PBB Summary section title = summary text …   Wikipedia Glypican 4 — Glypican 4, also known as GPC4, is a human gene.cite web | title = Entrez Gene: GPC4 glypican 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=2239| accessdate = ] PBB Summary section title = summary text …   Wikipedia Glypican 5 — Glypican 5, also known as GPC5, is a human gene.cite web | title = Entrez Gene: GPC5 glypican 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=2262| accessdate = ] PBB Summary section title = summary text …   Wikipedia Glypican 6 — Glypican 6, also known as GPC6, is a human gene.cite web | title = Entrez Gene: GPC6 glypican 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=10082| accessdate = ] PBB Summary section title = summary text …   Wikipedia Glypican — The glypican family of Heparan Sulfate proteoglycans are anchored to the cell surface via a covalent linkage to glycosylphosphatidylinositol (GPI). Six glypican family members have been identified in vertebrates, two in Drosophila and one in C.… …   Wikipedia glypican — noun Any of a family of heparan sulfate proteoglycans, anchored to the cell surface via a covalent linkage to glycosylphosphatidylinositol …   Wiktionary glypican — gly·pi·can (gliґpĭ kan) any of a family of integral membrane proteoglycans, consisting of a 62 kD core and four heparan sulfate chains, and expressed by lung, skin, epithelial, endothelial, and smooth muscle cells; the extracellular domain… …   Medical dictionary SLIT2 — Slit homolog 2 (Drosophila), also known as SLIT2, is a human gene.cite web | title = Entrez Gene: SLIT2 slit homolog 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=9353| accessdate = ] PBB… …   Wikipedia Co-receptor — A co receptor is a cell surface receptor that binds a signalling molecule in addition to a primary receptor in order to facilitate ligand recognition and initiate biological processes, such as entry of a pathogen into a host cell. Contents 1 Co… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”