- Glypican 2
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Glypican 2 Identifiers Symbols GPC2; DKFZp547M109; FLJ38962 External IDs MGI: 1919201 HomoloGene: 17657 GeneCards: GPC2 Gene Gene Ontology Molecular function • heparan sulfate proteoglycan binding Cellular component • extracellular region
• proteinaceous extracellular matrix
• extracellular space
• endoplasmic reticulum
• plasma membrane
• anchored to membraneBiological process • neuron differentiation Sources: Amigo / QuickGO Orthologs Species Human Mouse Entrez 221914 71951 Ensembl ENSG00000213420 ENSMUSG00000029510 UniProt Q8N158 A1A5C0 RefSeq (mRNA) NM_152742 NM_172412.2 RefSeq (protein) NP_689955 NP_766000.1 Location (UCSC) Chr 7:
99.77 – 99.77 MbChr 5:
138.71 – 138.72 MbPubMed search [1] [2] Glypican 2 (GPC2), also known cerebroglycan, is a protein which in humans is encoded by the GPC2 gene.[1][2]
Contents
Function
Cerebroglycan is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons.[3] Cerebroglycan has especially high affinity for laminin-1.[4]
See also
References
- ^ Stipp CS, Litwack ED, Lander AD (January 1994). "Cerebroglycan: an integral membrane heparan sulfate proteoglycan that is unique to the developing nervous system and expressed specifically during neuronal differentiation". J. Cell Biol. 124 (1–2): 149–160. doi:10.1083/jcb.124.1.149. PMC 2119891. PMID 8294498. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2119891.
- ^ "Entrez Gene: GPC2 glypican 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=221914.
- ^ Ivins JK, Litwack ED, Kumbasar A, Stipp CS, Lander AD (April 1997). "Cerebroglycan, a developmentally regulated cell-surface heparan sulfate proteoglycan, is expressed on developing axons and growth cones". Dev. Biol. 184 (2): 320–332. doi:10.1006/dbio.1997.8532. PMID 9133438.
- ^ Herndon ME, Stipp CS, Lander AD (February 1999). "Interactions of neural glycosaminoglycans and proteoglycans with protein ligands: assessment of selectivity, heterogeneity and the participation of core proteins in binding". Glycobiology 9 (2): 143–155. doi:10.1093/glycob/9.2.143. PMID 9949192.
External links
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