- Glypican 1
Glypican 1, also known as GPC1, is a human
gene .cite web | title = Entrez Gene: GPC1 glypican 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2817| accessdate = ]PBB_Summary
section_title =
summary_text = Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.cite web | title = Entrez Gene: GPC1 glypican 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2817| accessdate = ]ee also
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Glypican References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Karthikeyan L, Maurel P, Rauch U, "et al." |title=Cloning of a major heparan sulfate proteoglycan from brain and identification as the rat form of glypican. |journal=Biochem. Biophys. Res. Commun. |volume=188 |issue= 1 |pages= 395–401 |year= 1992 |pmid= 1417860 |doi=
*cite journal | author=David G, Lories V, Decock B, "et al." |title=Molecular cloning of a phosphatidylinositol-anchored membrane heparan sulfate proteoglycan from human lung fibroblasts. |journal=J. Cell Biol. |volume=111 |issue= 6 Pt 2 |pages= 3165–76 |year= 1991 |pmid= 2148568 |doi=
*cite journal | author=Vermeesch JR, Mertens G, David G, Marynen P |title=Assignment of the human glypican gene (GPC1) to 2q35-q37 by fluorescence in situ hybridization. |journal=Genomics |volume=25 |issue= 1 |pages= 327–9 |year= 1995 |pmid= 7774946 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Kleeff J, Ishiwata T, Kumbasar A, "et al." |title=The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer. |journal=J. Clin. Invest. |volume=102 |issue= 9 |pages= 1662–73 |year= 1998 |pmid= 9802880 |doi=
*cite journal | author=Gengrinovitch S, Berman B, David G, "et al." |title=Glypican-1 is a VEGF165 binding proteoglycan that acts as an extracellular chaperone for VEGF165. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 10816–22 |year= 1999 |pmid= 10196157 |doi=
*cite journal | author=Liang Y, Annan RS, Carr SA, "et al." |title=Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain. |journal=J. Biol. Chem. |volume=274 |issue= 25 |pages= 17885–92 |year= 1999 |pmid= 10364234 |doi=
*cite journal | author=Schofield KP, Gallagher JT, David G |title=Expression of proteoglycan core proteins in human bone marrow stroma. |journal=Biochem. J. |volume=343 Pt 3 |issue= |pages= 663–8 |year= 2000 |pmid= 10527946 |doi=
*cite journal | author=Karumanchi SA, Jha V, Ramchandran R, "et al." |title=Cell surface glypicans are low-affinity endostatin receptors. |journal=Mol. Cell |volume=7 |issue= 4 |pages= 811–22 |year= 2001 |pmid= 11336704 |doi=
*cite journal | author=Ronca F, Andersen JS, Paech V, Margolis RU |title=Characterization of Slit protein interactions with glypican-1. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 29141–7 |year= 2001 |pmid= 11375980 |doi= 10.1074/jbc.M100240200
*cite journal | author=Matsuda K, Maruyama H, Guo F, "et al." |title=Glypican-1 is overexpressed in human breast cancer and modulates the mitogenic effects of multiple heparin-binding growth factors in breast cancer cells. |journal=Cancer Res. |volume=61 |issue= 14 |pages= 5562–9 |year= 2001 |pmid= 11454708 |doi=
*cite journal | author=Alvarez K, Fadic R, Brandan E |title=Augmented synthesis and differential localization of heparan sulfate proteoglycans in Duchenne muscular dystrophy. |journal=J. Cell. Biochem. |volume=85 |issue= 4 |pages= 703–13 |year= 2002 |pmid= 11968010 |doi= 10.1002/jcb.10184
*cite journal | author=Ding K, Mani K, Cheng F, "et al." |title=Copper-dependent autocleavage of glypican-1 heparan sulfate by nitric oxide derived from intrinsic nitrosothiols. |journal=J. Biol. Chem. |volume=277 |issue= 36 |pages= 33353–60 |year= 2002 |pmid= 12084716 |doi= 10.1074/jbc.M203383200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Belting M, Mani K, Jönsson M, "et al." |title=Glypican-1 is a vehicle for polyamine uptake in mammalian cells: a pivital role for nitrosothiol-derived nitric oxide. |journal=J. Biol. Chem. |volume=278 |issue= 47 |pages= 47181–9 |year= 2004 |pmid= 12972423 |doi= 10.1074/jbc.M308325200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Watanabe N, Araki W, Chui DH, "et al." |title=Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease. |journal=FASEB J. |volume=18 |issue= 9 |pages= 1013–5 |year= 2004 |pmid= 15084524 |doi= 10.1096/fj.03-1040fje
*cite journal | author=Li J, Kleeff J, Kayed H, "et al." |title=Glypican-1 antisense transfection modulates TGF-beta-dependent signaling in Colo-357 pancreatic cancer cells. |journal=Biochem. Biophys. Res. Commun. |volume=320 |issue= 4 |pages= 1148–55 |year= 2004 |pmid= 15249209 |doi= 10.1016/j.bbrc.2004.06.063
*cite journal | author=Davies EJ, Blackhall FH, Shanks JH, "et al." |title=Distribution and clinical significance of heparan sulfate proteoglycans in ovarian cancer. |journal=Clin. Cancer Res. |volume=10 |issue= 15 |pages= 5178–86 |year= 2005 |pmid= 15297422 |doi= 10.1158/1078-0432.CCR-03-0103PBB_Controls
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