KCNA5

Potassium voltage-gated channel, shaker-related subfamily, member 5, also known as KCNA5 or K_v1.5, is a human gene.cite web | title = Entrez Gene: KCNA5 potassium voltage-gated channel, shaker-related subfamily, member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3741| accessdate = ]

PBB_Summary
section_title =
summary_text = Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12.cite web | title = Entrez Gene: KCNA5 potassium voltage-gated channel, shaker-related subfamily, member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3741| accessdate = ]

ee also

* Voltage-gated potassium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gutman GA, Chandy KG, Grissmer S, "et al." |title=International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 473–508 |year= 2006 |pmid= 16382104 |doi= 10.1124/pr.57.4.10
*cite journal | author=Curran ME, Landes GM, Keating MT |title=Molecular cloning, characterization, and genomic localization of a human potassium channel gene. |journal=Genomics |volume=12 |issue= 4 |pages= 729–37 |year= 1992 |pmid= 1349297 |doi=
*cite journal | author=Philipson LH, Hice RE, Schaefer K, "et al." |title=Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 1 |pages= 53–7 |year= 1991 |pmid= 1986382 |doi=
*cite journal | author=Tamkun MM, Knoth KM, Walbridge JA, "et al." |title=Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle. |journal=FASEB J. |volume=5 |issue= 3 |pages= 331–7 |year= 1991 |pmid= 2001794 |doi=
*cite journal | author=Mays DJ, Foose JM, Philipson LH, Tamkun MM |title=Localization of the Kv1.5 K+ channel protein in explanted cardiac tissue. |journal=J. Clin. Invest. |volume=96 |issue= 1 |pages= 282–92 |year= 1995 |pmid= 7615797 |doi=
*cite journal | author=Crumb WJ, Wible B, Arnold DJ, "et al." |title=Blockade of multiple human cardiac potassium currents by the antihistamine terfenadine: possible mechanism for terfenadine-associated cardiotoxicity. |journal=Mol. Pharmacol. |volume=47 |issue= 1 |pages= 181–90 |year= 1995 |pmid= 7838127 |doi=
*cite journal | author=Phromchotikul T, Browne DL, Curran ME, "et al." |title=Dinucleotide repeat polymorphism at the KCNA5 locus. |journal=Hum. Mol. Genet. |volume=2 |issue= 9 |pages= 1512 |year= 1993 |pmid= 8242092 |doi=
*cite journal | author=Albrecht B, Weber K, Pongs O |title=Characterization of a voltage-activated K-channel gene cluster on human chromosome 12p13. |journal=Recept. Channels |volume=3 |issue= 3 |pages= 213–20 |year= 1996 |pmid= 8821794 |doi=
*cite journal | author=Holmes TC, Fadool DA, Ren R, Levitan IB |title=Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain. |journal=Science |volume=274 |issue= 5295 |pages= 2089–91 |year= 1997 |pmid= 8953041 |doi=
*cite journal | author=Lacerda AE, Roy ML, Lewis EW, Rampe D |title=Interactions of the nonsedating antihistamine loratadine with a Kv1.5-type potassium channel cloned from human heart. |journal=Mol. Pharmacol. |volume=52 |issue= 2 |pages= 314–22 |year= 1997 |pmid= 9271355 |doi=
*cite journal | author=Kääb S, Dixon J, Duc J, "et al." |title=Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density. |journal=Circulation |volume=98 |issue= 14 |pages= 1383–93 |year= 1998 |pmid= 9760292 |doi=
*cite journal | author=Maruoka ND, Steele DF, Au BP, "et al." |title=alpha-actinin-2 couples to cardiac Kv1.5 channels, regulating current density and channel localization in HEK cells. |journal=FEBS Lett. |volume=473 |issue= 2 |pages= 188–94 |year= 2000 |pmid= 10812072 |doi=
*cite journal | author=Peretz A, Gil-Henn H, Sobko A, "et al." |title=Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon. |journal=EMBO J. |volume=19 |issue= 15 |pages= 4036–45 |year= 2000 |pmid= 10921884 |doi= 10.1093/emboj/19.15.4036
*cite journal | author=Nitabach MN, Llamas DA, Araneda RC, "et al." |title=A mechanism for combinatorial regulation of electrical activity: Potassium channel subunits capable of functioning as Src homology 3-dependent adaptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 2 |pages= 705–10 |year= 2001 |pmid= 11149959 |doi= 10.1073/pnas.031446198
*cite journal | author=Cukovic D, Lu GW, Wible B, "et al." |title=A discrete amino terminal domain of Kv1.5 and Kv1.4 potassium channels interacts with the spectrin repeats of alpha-actinin-2. |journal=FEBS Lett. |volume=498 |issue= 1 |pages= 87–92 |year= 2001 |pmid= 11389904 |doi=
*cite journal | author=Kurata HT, Soon GS, Eldstrom JR, "et al." |title=Amino-terminal determinants of U-type inactivation of voltage-gated K+ channels. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 29045–53 |year= 2002 |pmid= 12021261 |doi= 10.1074/jbc.M111470200
*cite journal | author=Williams CP, Hu N, Shen W, "et al." |title=Modulation of the human Kv1.5 channel by protein kinase C activation: role of the Kvbeta1.2 subunit. |journal=J. Pharmacol. Exp. Ther. |volume=302 |issue= 2 |pages= 545–50 |year= 2002 |pmid= 12130714 |doi= 10.1124/jpet.102.033357
*cite journal | author=Eldstrom J, Doerksen KW, Steele DF, Fedida D |title=N-terminal PDZ-binding domain in Kv1 potassium channels. |journal=FEBS Lett. |volume=531 |issue= 3 |pages= 529–37 |year= 2002 |pmid= 12435606 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zhang S, Kurata HT, Kehl SJ, Fedida D |title=Rapid induction of P/C-type inactivation is the mechanism for acid-induced K+ current inhibition. |journal=J. Gen. Physiol. |volume=121 |issue= 3 |pages= 215–25 |year= 2003 |pmid= 12601085 |doi=

External links

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