HNRNPC

Heterogeneous nuclear ribonucleoprotein C (C1/C2), also known as HNRPC, is a human gene.cite web | title = Entrez Gene: HNRPC heterogeneous nuclear ribonucleoprotein C (C1/C2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3183| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene.cite web | title = Entrez Gene: HNRPC heterogeneous nuclear ribonucleoprotein C (C1/C2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3183| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Görlach M, Wittekind M, Beckman RA, "et al." |title=Interaction of the RNA-binding domain of the hnRNP C proteins with RNA. |journal=EMBO J. |volume=11 |issue= 9 |pages= 3289–95 |year= 1992 |pmid= 1380452 |doi=
*cite journal | author=Wittekind M, Görlach M, Friedrichs M, "et al." |title=1H, 13C, and 15N NMR assignments and global folding pattern of the RNA-binding domain of the human hnRNP C proteins. |journal=Biochemistry |volume=31 |issue= 27 |pages= 6254–65 |year= 1992 |pmid= 1385725 |doi=
*cite journal | author=Burd CG, Swanson MS, Görlach M, Dreyfuss G |title=Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 24 |pages= 9788–92 |year= 1990 |pmid= 2557628 |doi=
*cite journal | author=Merrill BM, Barnett SF, LeStourgeon WM, Williams KR |title=Primary structure differences between proteins C1 and C2 of HeLa 40S nuclear ribonucleoprotein particles. |journal=Nucleic Acids Res. |volume=17 |issue= 21 |pages= 8441–9 |year= 1989 |pmid= 2587210 |doi=
*cite journal | author=Swanson MS, Nakagawa TY, LeVan K, Dreyfuss G |title=Primary structure of human nuclear ribonucleoprotein particle C proteins: conservation of sequence and domain structures in heterogeneous nuclear RNA, mRNA, and pre-rRNA-binding proteins. |journal=Mol. Cell. Biol. |volume=7 |issue= 5 |pages= 1731–9 |year= 1987 |pmid= 3110598 |doi=
*cite journal | author=Nakagawa TY, Swanson MS, Wold BJ, Dreyfuss G |title=Molecular cloning of cDNA for the nuclear ribonucleoprotein particle C proteins: a conserved gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 7 |pages= 2007–11 |year= 1986 |pmid= 3457372 |doi=
*cite journal | author=Sébillon P, Beldjord C, Kaplan JC, "et al." |title=A T to G mutation in the polypyrimidine tract of the second intron of the human beta-globin gene reduces in vitro splicing efficiency: evidence for an increased hnRNP C interaction. |journal=Nucleic Acids Res. |volume=23 |issue= 17 |pages= 3419–25 |year= 1995 |pmid= 7567451 |doi=
*cite journal | author=Kato S, Sekine S, Oh SW, "et al." |title=Construction of a human full-length cDNA bank. |journal=Gene |volume=150 |issue= 2 |pages= 243–50 |year= 1995 |pmid= 7821789 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Huang M, Rech JE, Northington SJ, "et al." |title=The C-protein tetramer binds 230 to 240 nucleotides of pre-mRNA and nucleates the assembly of 40S heterogeneous nuclear ribonucleoprotein particles. |journal=Mol. Cell. Biol. |volume=14 |issue= 1 |pages= 518–33 |year= 1994 |pmid= 8264621 |doi=
*cite journal | author=Hamilton BJ, Nagy E, Malter JS, "et al." |title=Association of heterogeneous nuclear ribonucleoprotein A1 and C proteins with reiterated AUUUA sequences. |journal=J. Biol. Chem. |volume=268 |issue= 12 |pages= 8881–7 |year= 1993 |pmid= 8473331 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Romero F, Ramos-Morales F, Domínguez A, "et al." |title=Grb2 and its apoptotic isoform Grb3-3 associate with heterogeneous nuclear ribonucleoprotein C, and these interactions are modulated by poly(U) RNA. |journal=J. Biol. Chem. |volume=273 |issue= 13 |pages= 7776–81 |year= 1998 |pmid= 9516488 |doi=
*cite journal | author=Neubauer G, King A, Rappsilber J, "et al." |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46–50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700
*cite journal | author=Sella O, Gerlitz G, Le SY, Elroy-Stein O |title=Differentiation-induced internal translation of c-sis mRNA: analysis of the cis elements and their differentiation-linked binding to the hnRNP C protein. |journal=Mol. Cell. Biol. |volume=19 |issue= 8 |pages= 5429–40 |year= 1999 |pmid= 10409733 |doi=
*cite journal | author=Wang W, Furneaux H, Cheng H, "et al." |title=HuR regulates p21 mRNA stabilization by UV light. |journal=Mol. Cell. Biol. |volume=20 |issue= 3 |pages= 760–9 |year= 2000 |pmid= 10629032 |doi=
*cite journal | author=Spångberg K, Wiklund L, Schwartz S |title=HuR, a protein implicated in oncogene and growth factor mRNA decay, binds to the 3' ends of hepatitis C virus RNA of both polarities. |journal=Virology |volume=274 |issue= 2 |pages= 378–90 |year= 2000 |pmid= 10964780 |doi= 10.1006/viro.2000.0461
*cite journal | author=Shahied L, Braswell EH, LeStourgeon WM, Krezel AM |title=An antiparallel four-helix bundle orients the high-affinity RNA binding sites in hnRNP C: a mechanism for RNA chaperonin activity. |journal=J. Mol. Biol. |volume=305 |issue= 4 |pages= 817–28 |year= 2001 |pmid= 11162094 |doi= 10.1006/jmbi.2000.4331
*cite journal | author=Andersen JS, Lyon CE, Fox AH, "et al." |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=
*cite journal | author=Stone JR, Collins T |title=Rapid phosphorylation of heterogeneous nuclear ribonucleoprotein C1/C2 in response to physiologic levels of hydrogen peroxide in human endothelial cells. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15621–8 |year= 2002 |pmid= 11877401 |doi= 10.1074/jbc.M112153200

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