KCNIP2

Kv channel interacting protein 2, also known as KCNIP2, is a human gene.cite web | title = Entrez Gene: KCNIP2 Kv channel interacting protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30819| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene.cite web | title = Entrez Gene: KCNIP2 Kv channel interacting protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30819| accessdate = ]

ee also

* Voltage-gated potassium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=An WF, Bowlby MR, Betty M, "et al." |title=Modulation of A-type potassium channels by a family of calcium sensors. |journal=Nature |volume=403 |issue= 6769 |pages= 553–6 |year= 2000 |pmid= 10676964 |doi= 10.1038/35000592
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Ohya S, Morohashi Y, Muraki K, "et al." |title=Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2. |journal=Biochem. Biophys. Res. Commun. |volume=282 |issue= 1 |pages= 96–102 |year= 2001 |pmid= 11263977 |doi= 10.1006/bbrc.2001.4558
*cite journal | author=Bähring R, Dannenberg J, Peters HC, "et al." |title=Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23888–94 |year= 2001 |pmid= 11287421 |doi= 10.1074/jbc.M101320200
*cite journal | author=Rosati B, Pan Z, Lypen S, "et al." |title=Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle. |journal=J. Physiol. (Lond.) |volume=533 |issue= Pt 1 |pages= 119–25 |year= 2001 |pmid= 11351020 |doi=
*cite journal | author=Decher N, Uyguner O, Scherer CR, "et al." |title=hKChIP2 is a functional modifier of hKv4.3 potassium channels: cloning and expression of a short hKChIP2 splice variant. |journal=Cardiovasc. Res. |volume=52 |issue= 2 |pages= 255–64 |year= 2002 |pmid= 11684073 |doi=
*cite journal | author=Kuo HC, Cheng CF, Clark RB, "et al." |title=A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia. |journal=Cell |volume=107 |issue= 6 |pages= 801–13 |year= 2002 |pmid= 11747815 |doi=
*cite journal | author=Deschênes I, DiSilvestre D, Juang GJ, "et al." |title=Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)? |journal=Circulation |volume=106 |issue= 4 |pages= 423–9 |year= 2002 |pmid= 12135940 |doi=
*cite journal | author=Deschênes I, Tomaselli GF |title=Modulation of Kv4.3 current by accessory subunits. |journal=FEBS Lett. |volume=528 |issue= 1-3 |pages= 183–8 |year= 2002 |pmid= 12297301 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Shibata R, Misonou H, Campomanes CR, "et al." |title=A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels. |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36445–54 |year= 2003 |pmid= 12829703 |doi= 10.1074/jbc.M306142200
*cite journal | author=Ren X, Shand SH, Takimoto K |title=Effective association of Kv channel-interacting proteins with Kv4 channel is mediated with their unique core peptide. |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 43564–70 |year= 2003 |pmid= 12928444 |doi= 10.1074/jbc.M302337200
*cite journal | author=Kim LA, Furst J, Butler MH, "et al." |title=Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5549–54 |year= 2004 |pmid= 14623880 |doi= 10.1074/jbc.M311332200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Kim LA, Furst J, Gutierrez D, "et al." |title=Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution. |journal=Neuron |volume=41 |issue= 4 |pages= 513–9 |year= 2004 |pmid= 14980201 |doi=
*cite journal | author=Lin YL, Lin SR, Wu TT, Chang LS |title=Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins. |journal=Biochem. Biophys. Res. Commun. |volume=319 |issue= 3 |pages= 720–4 |year= 2004 |pmid= 15184042 |doi= 10.1016/j.bbrc.2004.05.064
*cite journal | author=Rhodes KJ, Carroll KI, Sung MA, "et al." |title=KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain. |journal=J. Neurosci. |volume=24 |issue= 36 |pages= 7903–15 |year= 2005 |pmid= 15356203 |doi= 10.1523/JNEUROSCI.0776-04.2004
*cite journal | author=Lin YL, Chen CY, Cheng CP, Chang LS |title=Protein-protein interactions of KChIP proteins and Kv4.2. |journal=Biochem. Biophys. Res. Commun. |volume=321 |issue= 3 |pages= 606–10 |year= 2004 |pmid= 15358149 |doi= 10.1016/j.bbrc.2004.07.006
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

External links

*

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