Hippocalcin

Hippocalcin

protein
Name = hippocalcin
caption =


width =
HGNCid = 5144
Symbol = HPCA
AltSymbols =
EntrezGene = 3208
OMIM = 142622
RefSeq = NM_002143
UniProt = P84074
PDB =
ECnumber =
Chromosome = 1
Arm = p
Band = 35
LocusSupplementaryData = -p34.2

Hippocalcin (HPCA) is a calcium-binding protein that belongs to neuronal calcium sensor (NCS) family of proteins. It expressed in mammalian brains especially in the hippocampus. It possesses a Ca2+/myristoyl switch.

It takes part in the following prosesses:

* Activation of PLD and PLD2 expression

* Inhibition of apoptosis

* MAP kinase signalling

* Involved in long term depression in hippocampal neuron

* Required for normal spatial learning

It interacts with following proteins:

* Neuronal apoptosis inhibitory protein (NAIP)

* Mixed lineage kinase 2 (MLK2)MLK2 is myosin light chain kinase 2

* The b2 adaptin of the AP2 complex

* Calcium-dependent activator protein for secretion (CAPS)


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