KCNIP4

Kv channel interacting protein 4, also known as KCNIP4, is a human gene.cite web | title = Entrez Gene: KCNIP4 Kv channel interacting protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80333| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.cite web | title = Entrez Gene: KCNIP4 Kv channel interacting protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80333| accessdate = ]

ee also

* Voltage-gated potassium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Holmqvist MH, Cao J, Hernandez-Pineda R, "et al." |title=Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 2 |pages= 1035–40 |year= 2002 |pmid= 11805342 |doi= 10.1073/pnas.022509299
*cite journal | author=Morohashi Y, Hatano N, Ohya S, "et al." |title=Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4. |journal=J. Biol. Chem. |volume=277 |issue= 17 |pages= 14965–75 |year= 2002 |pmid= 11847232 |doi= 10.1074/jbc.M200897200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Lin YL, Lin SR, Wu TT, Chang LS |title=Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins. |journal=Biochem. Biophys. Res. Commun. |volume=319 |issue= 3 |pages= 720–4 |year= 2004 |pmid= 15184042 |doi= 10.1016/j.bbrc.2004.05.064
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hillier LW, Graves TA, Fulton RS, "et al." |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466
*cite journal | author=Pruunsild P, Timmusk T |title=Structure, alternative splicing, and expression of the human and mouse KCNIP gene family. |journal=Genomics |volume=86 |issue= 5 |pages= 581–93 |year= 2005 |pmid= 16112838 |doi= 10.1016/j.ygeno.2005.07.001
*cite journal | author=Chen CP, Lee L, Chang LS |title=Effects of metal-binding properties of human Kv channel-interacting proteins on their molecular structure and binding with Kv4.2 channel. |journal=Protein J. |volume=25 |issue= 5 |pages= 345–51 |year= 2007 |pmid= 16951992 |doi= 10.1007/s10930-006-9020-9
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134
*cite journal | author=Bonne A, Vreede L, Kuiper RP, "et al." |title=Mapping of constitutional translocation breakpoints in renal cell cancer patients: identification of KCNIP4 as a candidate gene. |journal=Cancer Genet. Cytogenet. |volume=179 |issue= 1 |pages= 11–8 |year= 2008 |pmid= 17981209 |doi= 10.1016/j.cancergencyto.2007.07.005

External links

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PBB_Controls
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