Calcium-induced calcium release
- Calcium-induced calcium release
Calcium-induced calcium release (CICR) is a mechanism of calcium release from muscle sarcoplasmic reticulum that was proposed in the 1970s [cite journal |author=Endo M.|title=Calcium release from the sarcoplasmic reticulum. |journal=Physiol Rev |volume=57 |issue=1 |pages=71–108 |year=1977 |pmid=13441] . Originally proposed for skeletal muscle, subsequent research has revealed that it is actually the predominant mechanism in cardiac muscle.
CICR in Excitation-Contraction (EC) Coupling
The mechanism that couples excitation - an action potential in the plasma membrane of the muscle cell - and contraction of heart muscle is an increase in the cell's cystolic calcium concentration. This calcium combines with the regulator protein troponin, initiating cross-bridge formation between actin and myosin.
The Paradox of Regenerative Release
Termination of CICR
References
Wikimedia Foundation.
2010.
Look at other dictionaries:
Calcium sparks — are calcium release events that occur within muscle cells. They are important in a physiological process called excitation contraction coupling, which is crucial to muscle function. In essence, electrical stimulation of the outer surface of a… … Wikipedia
CALCIUM ET MÉTABOLISME CELLULAIRE — Dans un organisme vivant, comme dans un central téléphonique, chacune des cellules émet, capte, analyse une grande masse d’informations. Une multitude de composés chimiques aussi différents que polypeptides ou stéroïdes sillonne notre corps et… … Encyclopédie Universelle
Calcium nitrate — Calcium nitrate … Wikipedia
Voltage-dependent calcium channel — Voltage dependent calcium channels (VDCC) are a group of voltage gated ion channels found in excitable cells (e.g., muscle, glial cells, neurons, etc.) with a permeability to the ion Ca2+.[1][2] These channels are slightly permeable to sodium… … Wikipedia
N-type calcium channel — Calcium channel, voltage dependent, N type, alpha 1B subunit Identifiers Symbols CACNA1B; BIII; CACNL1A5; CACNN; Cav2.2 External IDs … Wikipedia
Depolarization-induced suppression of inhibition — (DSI) is the classical and original electrophysiological example of endocannabinoid function in the central nervous system. Prior to the demonstration that DSI was dependent on the cannabinoid CB1 receptor function, there was no way of producing… … Wikipedia
Sodium-calcium exchanger — solute carrier family 8 (sodium/calcium exchanger), member 1 Identifiers Symbol SLC8A1 Alt. symbols NCX1 Entrez 6546 … Wikipedia
CAMLG — Calcium modulating ligand, also known as CAMLG, is a human gene.cite web | title = Entrez Gene: CAMLG calcium modulating ligand| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=819| accessdate = ] PBB… … Wikipedia
CICR — calcium induced calcium release process [calcium channel] … Medical dictionary
CICR — • calcium induced calcium release process [calcium channel] … Dictionary of medical acronyms & abbreviations
