CAMLG

Calcium modulating ligand, also known as CAMLG, is a human gene.cite web | title = Entrez Gene: CAMLG calcium modulating ligand| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=819| accessdate = ]

PBB_Summary
section_title =
summary_text = The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.cite web | title = Entrez Gene: CAMLG calcium modulating ligand| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=819| accessdate = ]

References

See also

* Calcium-modulating cyclophilin ligand

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bram RJ, Crabtree GR |title=Calcium signalling in T cells stimulated by a cyclophilin B-binding protein. |journal=Nature |volume=371 |issue= 6495 |pages= 355–8 |year= 1994 |pmid= 7522304 |doi= 10.1038/371355a0
*cite journal | author=Bram RJ, Valentine V, Shapiro DN, "et al." |title=The gene for calcium-modulating cyclophilin ligand (CAMLG) is located on human chromosome 5q23 and a syntenic region of mouse chromosome 13. |journal=Genomics |volume=31 |issue= 2 |pages= 257–60 |year= 1997 |pmid= 8824814 |doi= 10.1006/geno.1996.0044
*cite journal | author=von Bülow GU, Bram RJ |title=NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily. |journal=Science |volume=278 |issue= 5335 |pages= 138–41 |year= 1997 |pmid= 9311921 |doi=
*cite journal | author=Holloway MP, Bram RJ |title=Co-localization of calcium-modulating cyclophilin ligand with intracellular calcium pools. |journal=J. Biol. Chem. |volume=273 |issue= 26 |pages= 16346–50 |year= 1998 |pmid= 9632697 |doi=
*cite journal | author=Tovey SC, Bootman MD, Lipp P, "et al." |title=Calcium-modulating cyclophilin ligand desensitizes hormone-evoked calcium release. |journal=Biochem. Biophys. Res. Commun. |volume=276 |issue= 1 |pages= 97–100 |year= 2000 |pmid= 11006089 |doi= 10.1006/bbrc.2000.3442
*cite journal | author=Larramendy ML, Niini T, Elonen E, "et al." |title=Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis. |journal=Haematologica |volume=87 |issue= 6 |pages= 569–77 |year= 2003 |pmid= 12031912 |doi=
*cite journal | author=Feng P, Park J, Lee BS, "et al." |title=Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis. |journal=J. Virol. |volume=76 |issue= 22 |pages= 11491–504 |year= 2002 |pmid= 12388711 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Tran DD, Russell HR, Sutor SL, "et al." |title=CAML is required for efficient EGF receptor recycling. |journal=Dev. Cell |volume=5 |issue= 2 |pages= 245–56 |year= 2003 |pmid= 12919676 |doi=
*cite journal | author=Kumar R, Lutz W, Frank E, Im HJ |title=Immediate early gene X-1 interacts with proteins that modulate apoptosis. |journal=Biochem. Biophys. Res. Commun. |volume=323 |issue= 4 |pages= 1293–8 |year= 2004 |pmid= 15451437 |doi= 10.1016/j.bbrc.2004.09.006
*cite journal | author=Guo S, Lopez-Ilasaca M, Dzau VJ |title=Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation. |journal=J. Biol. Chem. |volume=280 |issue= 13 |pages= 12536–41 |year= 2005 |pmid= 15668245 |doi= 10.1074/jbc.M500296200
*cite journal | author=Nagano J, Kitamura K, Hujer KM, "et al." |title=Fibrocystin interacts with CAML, a protein involved in Ca2+ signaling. |journal=Biochem. Biophys. Res. Commun. |volume=338 |issue= 2 |pages= 880–9 |year= 2006 |pmid= 16243292 |doi= 10.1016/j.bbrc.2005.10.022

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes