Phospholamban

Phospholamban

Pfam_box
Symbol = Phospholamban
Name =


width =200
caption =Phospholamban pentamer
Pfam= PF04272
InterPro= IPR005984
SMART=
Prosite =
SCOP = 1fjk
TCDB = 8.A.11
OPM family= 70
OPM protein= 1zll
PDB=PDB3|1n7lA:1-52 PDB3|1plnD:35-52 PDB3|1k9nA:35-52PDB3|1plp :1-24 PDB3|1zllE:1-52 PDB3|1kchA:35-52PDB3|1pslC:35-52 PDB3|1fjkA:1-52 PDB3|1fjpA:1-52

protein
Name=Human phospholamban
caption=


width=
HGNCid=9080
Symbol=PLN
AltSymbols=PLB
EntrezGene=5350
OMIM=172405
RefSeq=NM_002667
UniProt=P26678
PDB=
ECnumber=
Chromosome=6
Arm=q
Band=22.1
LocusSupplementaryData=

Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca2+ pump in cardiac muscle and skeletal muscle cells. When phospholabman is phosphorylated by PKA its ability to to inhibit the sarcoplasmic reticulum calcium pump (SERCA) is lost. [Boron and Boulpaep. Medical Physiology, updated edition. 2005, Published by Elsevier Saunders. ISBN: 978-1-4160-2328-3 ] Thus, activators of PKA, such as the beta-adrenergic agonist epinephrine (reseased by sympathetic stiumlation) may enhance the rate of cardiac myocyte relaxation. Additionally, since SERCA is more active, the next action potential will cause an increased release of calcium resulting in increased contraction (positive inotropic effect). When phospholamban is not phosphorylated, such as when PKA is inactive, it can interact with and inhibit SERCA. The overall effect of phospholamban is to speed up the rate of muscle relaxation and increase contractility thereby increasing heart rate and stroke volume respectively.

Gene knockout of phospholamban results in animals with hyperdynamic hearts, with little apparent negative consequence.

References

* Karim, C. B., T. L. Kirby, Z. Zhang, Y. Nesmelov, and D. D. Thomas. 2004. Phospholamban structural dynamics in lipid bilayers probed by a spin label rigidly coupled to the peptide backbone. Proc Natl Acad Sci USA, 101(40): 14437-14442. Entrez Pubmed|15448204

* Brittsan, A. G. & Kranias, E. G. Phospholamban and cardiac contractile function. J. Mol. Cell. Cardiol. 32, 2131-2139 (2000). Entrez Pubmed|11112989

External links

* - Orientations of phospholamban and sarcolipin in membrane]


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