- PLN (gene)
Phospholamban, also known as PLN, is a human
gene .PBB_Summary
section_title =
summary_text = The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [cite web | title = Entrez Gene: PLN phospholamban| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5350| accessdate = ]ee also
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Phospholamban References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Kadambi VJ, Kranias EG |title=Phospholamban: a protein coming of age. |journal=Biochem. Biophys. Res. Commun. |volume=239 |issue= 1 |pages= 1–5 |year= 1997 |pmid= 9345259 |doi= 10.1006/bbrc.1997.7340PBB_Controls
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