FBLN1

Fibulin 1, also known as FBLN1, is a human gene.

PBB_Summary
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summary_text = Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants.cite web | title = Entrez Gene: FBLN1 fibulin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2192| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Balbona K, Tran H, Godyna S, "et al." |title=Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of fibronectin. |journal=J. Biol. Chem. |volume=267 |issue= 28 |pages= 20120–5 |year= 1992 |pmid= 1400330 |doi=
*cite journal | author=Argraves WS, Tran H, Burgess WH, Dickerson K |title=Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure. |journal=J. Cell Biol. |volume=111 |issue= 6 Pt 2 |pages= 3155–64 |year= 1991 |pmid= 2269669 |doi=
*cite journal | author=Argraves WS, Dickerson K, Burgess WH, Ruoslahti E |title=Fibulin, a novel protein that interacts with the fibronectin receptor beta subunit cytoplasmic domain. |journal=Cell |volume=58 |issue= 4 |pages= 623–9 |year= 1989 |pmid= 2527614 |doi=
*cite journal | author=Sasaki T, Göhring W, Pan TC, "et al." |title=Binding of mouse and human fibulin-2 to extracellular matrix ligands. |journal=J. Mol. Biol. |volume=254 |issue= 5 |pages= 892–9 |year= 1996 |pmid= 7500359 |doi= 10.1006/jmbi.1995.0664
*cite journal | author=Roark EF, Keene DR, Haudenschild CC, "et al." |title=The association of human fibulin-1 with elastic fibers: an immunohistological, ultrastructural, and RNA study. |journal=J. Histochem. Cytochem. |volume=43 |issue= 4 |pages= 401–11 |year= 1995 |pmid= 7534784 |doi=
*cite journal | author=Tran H, Tanaka A, Litvinovich SV, "et al." |title=The interaction of fibulin-1 with fibrinogen. A potential role in hemostasis and thrombosis. |journal=J. Biol. Chem. |volume=270 |issue= 33 |pages= 19458–64 |year= 1995 |pmid= 7642629 |doi=
*cite journal | author=Mattei MG, Pan TC, Zhang RZ, "et al." |title=The fibulin-1 gene (FBLN1) is located on human chromosome 22 and on mouse chromosome 15. |journal=Genomics |volume=22 |issue= 2 |pages= 437–8 |year= 1995 |pmid= 7806231 |doi= 10.1006/geno.1994.1406
*cite journal | author=Korenberg JR, Chen XN, Tran H, Argraves WS |title=Localization of the human gene for fibulin-1 (FBLN1) to chromosome band 22q13.3. |journal=Cytogenet. Cell Genet. |volume=68 |issue= 3-4 |pages= 192–3 |year= 1995 |pmid= 7842734 |doi=
*cite journal | author=Brown JC, Wiedemann H, Timpl R |title=Protein binding and cell adhesion properties of two laminin isoforms (AmB1eB2e, AmB1sB2e) from human placenta. |journal=J. Cell. Sci. |volume=107 ( Pt 1) |issue= |pages= 329–38 |year= 1994 |pmid= 8175920 |doi=
*cite journal | author=Pan TC, Kluge M, Zhang RZ, "et al." |title=Sequence of extracellular mouse protein BM-90/fibulin and its calcium-dependent binding to other basement-membrane ligands. |journal=Eur. J. Biochem. |volume=215 |issue= 3 |pages= 733–40 |year= 1993 |pmid= 8354280 |doi=
*cite journal | author=Clinton GM, Rougeot C, Derancourt J, "et al." |title=Estrogens increase the expression of fibulin-1, an extracellular matrix protein secreted by human ovarian cancer cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 316–20 |year= 1996 |pmid= 8552629 |doi=
*cite journal | author=Miosge N, Götz W, Sasaki T, "et al." |title=The extracellular matrix proteins fibulin-1 and fibulin-2 in the early human embryo. |journal=Histochem. J. |volume=28 |issue= 2 |pages= 109–16 |year= 1996 |pmid= 8737292 |doi=
*cite journal | author=Godyna S, Diaz-Ricart M, Argraves WS |title=Fibulin-1 mediates platelet adhesion via a bridge of fibrinogen. |journal=Blood |volume=88 |issue= 7 |pages= 2569–77 |year= 1996 |pmid= 8839849 |doi=
*cite journal | author=Tran H, Mattei M, Godyna S, Argraves WS |title=Human fibulin-1D: molecular cloning, expression and similarity with S1-5 protein, a new member of the fibulin gene family. |journal=Matrix Biol. |volume=15 |issue= 7 |pages= 479–93 |year= 1997 |pmid= 9106159 |doi=
*cite journal | author=Tran H, VanDusen WJ, Argraves WS |title=The self-association and fibronectin-binding sites of fibulin-1 map to calcium-binding epidermal growth factor-like domains. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22600–6 |year= 1997 |pmid= 9278415 |doi=
*cite journal | author=Adam S, Göhring W, Wiedemann H, "et al." |title=Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules. |journal=J. Mol. Biol. |volume=272 |issue= 2 |pages= 226–36 |year= 1997 |pmid= 9299350 |doi= 10.1006/jmbi.1997.1244
*cite journal | author=Qing J, Maher VM, Tran H, "et al." |title=Suppression of anchorage-independent growth and matrigel invasion and delayed tumor formation by elevated expression of fibulin-1D in human fibrosarcoma-derived cell lines. |journal=Oncogene |volume=15 |issue= 18 |pages= 2159–68 |year= 1997 |pmid= 9393974 |doi= 10.1038/sj.onc.1201385
*cite journal | author=Hayashido Y, Lucas A, Rougeot C, "et al." |title=Estradiol and fibulin-1 inhibit motility of human ovarian- and breast-cancer cells induced by fibronectin. |journal=Int. J. Cancer |volume=75 |issue= 4 |pages= 654–8 |year= 1998 |pmid= 9466671 |doi=
*cite journal | author=Roger P, Pujol P, Lucas A, "et al." |title=Increased immunostaining of fibulin-1, an estrogen-regulated protein in the stroma of human ovarian epithelial tumors. |journal=Am. J. Pathol. |volume=153 |issue= 5 |pages= 1579–88 |year= 1998 |pmid= 9811350 |doi=
*cite journal | author=Perbal B, Martinerie C, Sainson R, "et al." |title=The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 3 |pages= 869–74 |year= 1999 |pmid= 9927660 |doi=

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