- TRPC
TRPC is a family of
transient receptor potential cation channels in animals.TRPC channels form the subfamily of channels in human most closely related to drosophila TRP channels. Structurally, this family shares a number of similar characteristics. At the proximal C-terminus of this sub-family is a TRP box motif containing the invariant EWKFAR sequence and between 3 and 4 ankyrin repeats near the N-terminus. These channels are non-selectively permeable to cations, with a selectivity of calcium over sodium variable among the different members. Many of TRPC channel subunits are able to coassemble.cite journal
author=Nilius B, Owsianik G, Voets T, Peters JA
title=Transient receptor potential cation channels in disease
journal=Physiol. Rev.
volume=87
issue=1
pages=165–217
year=2007
pmid=17237345
doi=10.1152/physrev.00021.2006 ]In general, TRPC channels can be activated by
phospholipase C stimulation, with some members also activated by diacylglycerol. There is one at least one report that TRPC1 is also activated by stretching of the membrane and TRP5 channels are activated by extracellular reducedthioredoxin .cite journal
author = S. H. Xu, P. Sukumar, F. Zeng et al.
year = 2008
title = TRPC channel activation by extracellular thioredoxin
journal = Nature
volume = 7174
issue =
pages = 69–72
location =
pmid = 18172497
doi = 10.1038/nature06414]It has long been proposed that TRPC channels underlie the store-operated channels (SOC) observed in many cell types. These channels open due to the depletion of intracellular calcium stores. Two other proteins, stromal interaction molecules (STIMs) and the ORAIs, however, have more recently been implicated in this process. It should be noted that
STIM1 andTRPC1 can coassemble, complicating the understanding of this phenomenon.TRPC6 and TRPC4 have been implicated in late onset Alzheimer's disease. [cite journal
author=Lessard CB, Lussier MP, Cayouette S, Bourque G, Boulay G.
title=The overexpression of presenilin2 and Alzheimer's-disease-linked presenilin2 variants influences TRPC6-enhanced Ca2+ entry into HEK293 cells.
journal=Cell Signal
volume=17
pages=437–445
year=2005
doi=10.1016/j.cellsig.2004.09.005] [cite news
url=http://www.eurekalert.org/pub_releases/2008-05/mcog-fsl051408.php
title=Families shed light on likely causative gene for Alzheimer's] [cite journal
title=Genome screen of late-onset Alzheimer's extended pedigrees identifies TRPC4AP by haplotype analysis.
author=Poduslo SE, Huang R, Huang J, Smith S
journal=Am J Med Genet B Neuropsychiatr Genet
date=2008-04-30 [Epub ahead of print]
pmid=18449908
doi=10.1002/ajmg.b.30767]Genes
*
TRPC1 ,TRPC2 ,TRPC3 ,TRPC4 ,TRPC5 ,TRPC6 ,TRPC7 References
External links
*MeshName|TRPC+Cation+Channels
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