The Kir2.1 inward-rectifier potassium ion channel is encoded by the gene|KCNJ2 gene.[cite journal | author = Raab-Graham KF, Radeke CM, Vandenberg CA | title = Molecular cloning and expression of a human heart inward rectifier potassium channel | journal = Neuroreport | volume = 5 | issue = 18 | pages = 2501–5 | year = 1994 | pmid = 7696590 | doi = | issn = ] ][cite journal | author = Derst C, Karschin C, Wischmeyer E, Hirsch JR, Preisig-Müller R, Rajan S, Engel H, Grzeschik K, Daut J, Karschin A | title = Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits | journal = FEBS Lett. | volume = 491 | issue = 3 | pages = 305–11 | year = 2001 | pmid = 11240146 | doi = 10.1016/S0014-5793(01)02202-5 | issn = ] ][cite journal | author = Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA | title = International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels | journal = Pharmacol. Rev. | volume = 57 | issue = 4 | pages = 509–26 | year = 2005 | pmid = 16382105 | doi = 10.1124/pr.57.4.11 | issn = ] ]Clinical significance
A defect in this gene is associated with Andersen-Tawil syndrome.[cite journal | author = Donaldson MR, Yoon G, Fu YH, Ptacek LJ | title = Andersen-Tawil syndrome: a model of clinical variability, pleiotropy, and genetic heterogeneity | journal = Ann. Med. | volume = 36 Suppl 1 | issue = | pages = 92–7 | year = 2004 | pmid = 15176430 | doi = | issn = ] ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Kubo Y, Adelman JP, Clapham DE, "et al." |title=International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 509–26 |year= 2006 |pmid= 16382105 |doi= 10.1124/pr.57.4.11
*cite journal | author=Wood LS, Tsai TD, Lee KS, Vogeli G |title=Cloning and functional expression of a human gene, hIRK1, encoding the heart inward rectifier K+-channel. |journal=Gene |volume=163 |issue= 2 |pages= 313–7 |year= 1995 |pmid= 7590287 |doi=
*cite journal | author=Kubo Y, Baldwin TJ, Jan YN, Jan LY |title=Primary structure and functional expression of a mouse inward rectifier potassium channel. |journal=Nature |volume=362 |issue= 6416 |pages= 127–33 |year= 1993 |pmid= 7680768 |doi= 10.1038/362127a0
*cite journal | author=Raab-Graham KF, Radeke CM, Vandenberg CA |title=Molecular cloning and expression of a human heart inward rectifier potassium channel. |journal=Neuroreport |volume=5 |issue= 18 |pages= 2501–5 |year= 1995 |pmid= 7696590 |doi=
*cite journal | author=Ashen MD, O'Rourke B, Kluge KA, "et al." |title=Inward rectifier K+ channel from human heart and brain: cloning and stable expression in a human cell line. |journal=Am. J. Physiol. |volume=268 |issue= 1 Pt 2 |pages= H506–11 |year= 1995 |pmid= 7840300 |doi=
*cite journal | author=Tang W, Qin CL, Yang XC |title=Cloning, localization, and functional expression of a human brain inward rectifier potassium channel (hIRK1). |journal=Recept. Channels |volume=3 |issue= 3 |pages= 175–83 |year= 1996 |pmid= 8821791 |doi=
*cite journal | author=Tare M, Prestwich SA, Gordienko DV, "et al." |title=Inwardly rectifying whole cell potassium current in human blood eosinophils. |journal=J. Physiol. (Lond.) |volume=506 ( Pt 2) |issue= |pages= 303–18 |year= 1998 |pmid= 9490857 |doi=
*cite journal | author=Rae JL, Shepard AR |title=Inwardly rectifying potassium channels in lens epithelium are from the IRK1 (Kir 2.1) family. |journal=Exp. Eye Res. |volume=66 |issue= 3 |pages= 347–59 |year= 1998 |pmid= 9533862 |doi= 10.1006/exer.1997.0432
*cite journal | author=Kurschner C, Yuzaki M |title=Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein. |journal=J. Neurosci. |volume=19 |issue= 18 |pages= 7770–80 |year= 1999 |pmid= 10479680 |doi=
*cite journal | author=Tucker SJ, Ashcroft FM |title=Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2. |journal=J. Biol. Chem. |volume=274 |issue= 47 |pages= 33393–7 |year= 1999 |pmid= 10559219 |doi=
*cite journal | author=Nehring RB, Wischmeyer E, Döring F, "et al." |title=Neuronal inwardly rectifying K(+) channels differentially couple to PDZ proteins of the PSD-95/SAP90 family. |journal=J. Neurosci. |volume=20 |issue= 1 |pages= 156–62 |year= 2000 |pmid= 10627592 |doi=
*cite journal | author=Leonoudakis D, Mailliard W, Wingerd K, "et al." |title=Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97. |journal=J. Cell. Sci. |volume=114 |issue= Pt 5 |pages= 987–98 |year= 2001 |pmid= 11181181 |doi=
*cite journal | author=Derst C, Karschin C, Wischmeyer E, "et al." |title=Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits. |journal=FEBS Lett. |volume=491 |issue= 3 |pages= 305–11 |year= 2001 |pmid= 11240146 |doi=
*cite journal | author=Stockklausner C, Ludwig J, Ruppersberg JP, Klöcker N |title=A sequence motif responsible for ER export and surface expression of Kir2.0 inward rectifier K(+) channels. |journal=FEBS Lett. |volume=493 |issue= 2-3 |pages= 129–33 |year= 2001 |pmid= 11287009 |doi=
*cite journal | author=Dart C, Leyland ML |title=Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 20499–505 |year= 2001 |pmid= 11287423 |doi= 10.1074/jbc.M101425200
*cite journal | author=Plaster NM, Tawil R, Tristani-Firouzi M, "et al." |title=Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome. |journal=Cell |volume=105 |issue= 4 |pages= 511–9 |year= 2001 |pmid= 11371347 |doi=
*cite journal | author=Jeong JS, Lee HJ, Jung JS, "et al." |title=Characterization of inwardly rectifying K(+) conductance across the basolateral membrane of rat tracheal epithelia. |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 4 |pages= 914–20 |year= 2001 |pmid= 11688996 |doi= 10.1006/bbrc.2001.5831
*cite journal | author=Giovannardi S, Forlani G, Balestrini M, "et al." |title=Modulation of the inward rectifier potassium channel IRK1 by the Ras signaling pathway. |journal=J. Biol. Chem. |volume=277 |issue= 14 |pages= 12158–63 |year= 2002 |pmid= 11809752 |doi= 10.1074/jbc.M110466200
*cite journal | author=Preisig-Müller R, Schlichthörl G, Goerge T, "et al." |title=Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 11 |pages= 7774–9 |year= 2002 |pmid= 12032359 |doi= 10.1073/pnas.102609499
*cite journal | author=Ai T, Fujiwara Y, Tsuji K, "et al." |title=Novel KCNJ2 mutation in familial periodic paralysis with ventricular dysrhythmia. |journal=Circulation |volume=105 |issue= 22 |pages= 2592–4 |year= 2002 |pmid= 12045162 |doi=
External links
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