Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8 or KIR6.1, is a human gene.cite web | title = Entrez Gene: KCNJ8 potassium inwardly-rectifying channel, subfamily J, member 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3764| accessdate = ]

section_title =
summary_text = Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.cite web | title = Entrez Gene: KCNJ8 potassium inwardly-rectifying channel, subfamily J, member 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3764| accessdate = ]

ee also

* Inward-rectifier potassium ion channel


Further reading

citations =
*cite journal | author=Kubo Y, Adelman JP, Clapham DE, "et al." |title=International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 509–26 |year= 2006 |pmid= 16382105 |doi= 10.1124/pr.57.4.11
*cite journal | author=Inagaki N, Tsuura Y, Namba N, "et al." |title=Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and heart. |journal=J. Biol. Chem. |volume=270 |issue= 11 |pages= 5691–4 |year= 1995 |pmid= 7890693 |doi=
*cite journal | author=Inagaki N, Inazawa J, Seino S |title=cDNA sequence, gene structure, and chromosomal localization of the human ATP-sensitive potassium channel, uKATP-1, gene (KCNJ8). |journal=Genomics |volume=30 |issue= 1 |pages= 102–4 |year= 1996 |pmid= 8595887 |doi= 10.1006/geno.1995.0018
*cite journal | author=Suzuki M, Kotake K, Fujikura K, "et al." |title=Kir6.1: a possible subunit of ATP-sensitive K+ channels in mitochondria. |journal=Biochem. Biophys. Res. Commun. |volume=241 |issue= 3 |pages= 693–7 |year= 1998 |pmid= 9434770 |doi= 10.1006/bbrc.1997.7891
*cite journal | author=Erginel-Unaltuna N, Yang WP, Blanar MA |title=Genomic organization and expression of KCNJ8/Kir6.1, a gene encoding a subunit of an ATP-sensitive potassium channel. |journal=Gene |volume=211 |issue= 1 |pages= 71–8 |year= 1998 |pmid= 9573340 |doi=
*cite journal | author=Surah-Narwal S, Xu SZ, McHugh D, "et al." |title=Block of human aorta Kir6.1 by the vascular KATP channel inhibitor U37883A. |journal=Br. J. Pharmacol. |volume=128 |issue= 3 |pages= 667–72 |year= 1999 |pmid= 10516647 |doi= 10.1038/sj.bjp.0702862
*cite journal | author=Tucker SJ, Ashcroft FM |title=Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2. |journal=J. Biol. Chem. |volume=274 |issue= 47 |pages= 33393–7 |year= 1999 |pmid= 10559219 |doi=
*cite journal | author=Kono Y, Horie M, Takano M, "et al." |title=The properties of the Kir6.1-6.2 tandem channel co-expressed with SUR2A. |journal=Pflugers Arch. |volume=440 |issue= 5 |pages= 692–8 |year= 2001 |pmid= 11007308 |doi=
*cite journal | author=Cui Y, Giblin JP, Clapp LH, Tinker A |title=A mechanism for ATP-sensitive potassium channel diversity: Functional coassembly of two pore-forming subunits. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 2 |pages= 729–34 |year= 2001 |pmid= 11136227 |doi= 10.1073/pnas.011370498
*cite journal | author=Liu Y, Ren G, O'Rourke B, "et al." |title=Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels. |journal=Mol. Pharmacol. |volume=59 |issue= 2 |pages= 225–30 |year= 2001 |pmid= 11160857 |doi=
*cite journal | author=Giblin JP, Cui Y, Clapp LH, Tinker A |title=Assembly limits the pharmacological complexity of ATP-sensitive potassium channels. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13717–23 |year= 2002 |pmid= 11825905 |doi= 10.1074/jbc.M112209200
*cite journal | author=Vanoye CG, MacGregor GG, Dong K, "et al." |title=The carboxyl termini of K(ATP) channels bind nucleotides. |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23260–70 |year= 2002 |pmid= 11956191 |doi= 10.1074/jbc.M112004200
*cite journal | author=Miki T, Suzuki M, Shibasaki T, "et al." |title=Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1. |journal=Nat. Med. |volume=8 |issue= 5 |pages= 466–72 |year= 2002 |pmid= 11984590 |doi= 10.1038/nm0502-466
*cite journal | author=Nakamura K, Hirano J, Itazawa S, Kubokawa M |title=Protein kinase G activates inwardly rectifying K(+) channel in cultured human proximal tubule cells. |journal=Am. J. Physiol. Renal Physiol. |volume=283 |issue= 4 |pages= F784–91 |year= 2002 |pmid= 12217870 |doi= 10.1152/ajprenal.00023.2002
*cite journal | author=Curley M, Cairns MT, Friel AM, "et al." |title=Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometrium. |journal=Mol. Hum. Reprod. |volume=8 |issue= 10 |pages= 941–5 |year= 2003 |pmid= 12356945 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Singh H, Hudman D, Lawrence CL, "et al." |title=Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated ventricular myocytes. |journal=J. Mol. Cell. Cardiol. |volume=35 |issue= 5 |pages= 445–59 |year= 2004 |pmid= 12738227 |doi=
*cite journal | author=Insuk SO, Chae MR, Choi JW, "et al." |title=Molecular basis and characteristics of KATP channel in human corporal smooth muscle cells. |journal=Int. J. Impot. Res. |volume=15 |issue= 4 |pages= 258–66 |year= 2003 |pmid= 12934053 |doi= 10.1038/sj.ijir.3901013
*cite journal | author=Emanuele E, Falcone C, Carabela M, "et al." |title=Absence of Kir6.1/KCNJ8 mutations in Italian patients with abnormal coronary vasomotion. |journal=Int. J. Mol. Med. |volume=12 |issue= 4 |pages= 509–12 |year= 2004 |pmid= 12964027 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

External links


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