CACNG2

Calcium channel, voltage-dependent, gamma subunit 2, also known as CACNG2, is a human gene.cite web | title = Entrez Gene: CACNG2 calcium channel, voltage-dependent, gamma subunit 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10369| accessdate = ]

PBB_Summary
section_title =
summary_text = L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This protein is similar to the mouse stargazin protein, mutations in which have been associated with absence seizures, also known as petit-mal or spike-wave seizures. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family.cite web | title = Entrez Gene: CACNG2 calcium channel, voltage-dependent, gamma subunit 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10369| accessdate = ]

ee also

* Voltage-dependent calcium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Powers PA, Liu S, Hogan K, Gregg RG |title=Molecular characterization of the gene encoding the gamma subunit of the human skeletal muscle 1,4-dihydropyridine-sensitive Ca2+ channel (CACNLG), cDNA sequence, gene structure, and chromosomal location. |journal=J. Biol. Chem. |volume=268 |issue= 13 |pages= 9275–9 |year= 1993 |pmid= 8387489 |doi=
*cite journal | author=Black JL, Lennon VA |title=Identification and cloning of putative human neuronal voltage-gated calcium channel gamma-2 and gamma-3 subunits: neurologic implications. |journal=Mayo Clin. Proc. |volume=74 |issue= 4 |pages= 357–61 |year= 1999 |pmid= 10221464 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Burgess DL, Matsuura T, Ashizawa T, Noebels JL |title=Genetic localization of the Ca2+ channel gene CACNG2 near SCA10 on chromosome 22q13. |journal=Epilepsia |volume=41 |issue= 1 |pages= 24–7 |year= 2000 |pmid= 10643919 |doi=
*cite journal | author=Chen L, Chetkovich DM, Petralia RS, "et al." |title=Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. |journal=Nature |volume=408 |issue= 6815 |pages= 936–43 |year= 2001 |pmid= 11140673 |doi= 10.1038/35050030
*cite journal | author=Burgess DL, Gefrides LA, Foreman PJ, Noebels JL |title=A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family. |journal=Genomics |volume=71 |issue= 3 |pages= 339–50 |year= 2001 |pmid= 11170751 |doi= 10.1006/geno.2000.6440
*cite journal | author=Choi J, Ko J, Park E, "et al." |title=Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95. |journal=J. Biol. Chem. |volume=277 |issue= 14 |pages= 12359–63 |year= 2002 |pmid= 11805122 |doi= 10.1074/jbc.M200528200
*cite journal | author=Schnell E, Sizemore M, Karimzadegan S, "et al." |title=Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 21 |pages= 13902–7 |year= 2002 |pmid= 12359873 |doi= 10.1073/pnas.172511199
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Moss FJ, Dolphin AC, Clare JJ |title=Human neuronal stargazin-like proteins, gamma2, gamma3 and gamma4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes. |journal=BMC neuroscience |volume=4 |issue= |pages= 23 |year= 2004 |pmid= 14505496 |doi= 10.1186/1471-2202-4-23
*cite journal | author=Tomita S, Fukata M, Nicoll RA, Bredt DS |title=Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses. |journal=Science |volume=303 |issue= 5663 |pages= 1508–11 |year= 2004 |pmid= 15001777 |doi= 10.1126/science.1090262
*cite journal | author=Collins JE, Wright CL, Edwards CA, "et al." |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Yamazaki M, Ohno-Shosaku T, Fukaya M, "et al." |title=A novel action of stargazin as an enhancer of AMPA receptor activity. |journal=Neurosci. Res. |volume=50 |issue= 4 |pages= 369–74 |year= 2005 |pmid= 15567474 |doi= 10.1016/j.neures.2004.10.002
*cite journal | author=Priel A, Kolleker A, Ayalon G, "et al." |title=Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors. |journal=J. Neurosci. |volume=25 |issue= 10 |pages= 2682–6 |year= 2006 |pmid= 15758178 |doi= 10.1523/JNEUROSCI.4834-04.2005
*cite journal | author=Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G |title=Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays. |journal=J. Am. Chem. Soc. |volume=128 |issue= 17 |pages= 5913–22 |year= 2007 |pmid= 16637659 |doi= 10.1021/ja060943h
*cite journal | author=Bedoukian MA, Weeks AM, Partin KM |title=Different domains of the AMPA receptor direct stargazin-mediated trafficking and stargazin-mediated modulation of kinetics. |journal=J. Biol. Chem. |volume=281 |issue= 33 |pages= 23908–21 |year= 2006 |pmid= 16793768 |doi= 10.1074/jbc.M600679200
*cite journal | author=Körber C, Werner M, Hoffmann J, "et al." |title=Stargazin interaction with alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors is critically dependent on the amino acid at the narrow constriction of the ion channel. |journal=J. Biol. Chem. |volume=282 |issue= 26 |pages= 18758–66 |year= 2007 |pmid= 17483093 |doi= 10.1074/jbc.M611182200

External links

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