Potassium channel, subfamily K, member 3, also known as KCNK3, is a human gene.cite web | title = Entrez Gene: KCNK3 potassium channel, subfamily K, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3777| accessdate = ]

section_title =
summary_text = This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The gene product is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.cite web | title = Entrez Gene: KCNK3 potassium channel, subfamily K, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3777| accessdate = ]

ee also

* Tandem pore domain potassium channel


Further reading

citations =
*cite journal | author=Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N |title=Potassium leak channels and the KCNK family of two-P-domain subunits. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 175-84 |year= 2001 |pmid= 11256078 |doi=
*cite journal | author=Goldstein SA, Bayliss DA, Kim D, "et al." |title=International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 527-40 |year= 2006 |pmid= 16382106 |doi= 10.1124/pr.57.4.12
*cite journal | author=Duprat F, Lesage F, Fink M, "et al." |title=TASK, a human background K+ channel to sense external pH variations near physiological pH. |journal=EMBO J. |volume=16 |issue= 17 |pages= 5464-71 |year= 1997 |pmid= 9312005 |doi= 10.1093/emboj/16.17.5464
*cite journal | author=Lesage F, Lazdunski M |title=Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23. |journal=Genomics |volume=51 |issue= 3 |pages= 478-9 |year= 1998 |pmid= 9721223 |doi= 10.1006/geno.1998.5397
*cite journal | author=Patel AJ, Honoré E, Lesage F, "et al." |title=Inhalational anesthetics activate two-pore-domain background K+ channels. |journal=Nat. Neurosci. |volume=2 |issue= 5 |pages= 422-6 |year= 1999 |pmid= 10321245 |doi= 10.1038/8084
*cite journal | author=Manjunath NA, Bray-Ward P, Goldstein SA, Gallagher PG |title=Assignment of the 2P domain, acid-sensitive potassium channel OAT1 gene KCNK3 to human chromosome bands 2p24.1-->p23.3 and murine 5B by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=86 |issue= 3-4 |pages= 242-3 |year= 2000 |pmid= 10575216 |doi=
*cite journal | author=Lopes CM, Gallagher PG, Buck ME, "et al." |title=Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3. |journal=J. Biol. Chem. |volume=275 |issue= 22 |pages= 16969-78 |year= 2000 |pmid= 10748056 |doi= 10.1074/jbc.M001948200
*cite journal | author=Ashmole I, Goodwin PA, Stanfield PR |title=TASK-5, a novel member of the tandem pore K+ channel family. |journal=Pflugers Arch. |volume=442 |issue= 6 |pages= 828-33 |year= 2002 |pmid= 11680614 |doi=
*cite journal | author=Talley EM, Bayliss DA |title=Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) potassium channels: volatile anesthetics and neurotransmitters share a molecular site of action. |journal=J. Biol. Chem. |volume=277 |issue= 20 |pages= 17733-42 |year= 2002 |pmid= 11886861 |doi= 10.1074/jbc.M200502200
*cite journal | author=Buist SC, Cherrington NJ, Choudhuri S, "et al." |title=Gender-specific and developmental influences on the expression of rat organic anion transporters. |journal=J. Pharmacol. Exp. Ther. |volume=301 |issue= 1 |pages= 145-51 |year= 2002 |pmid= 11907168 |doi=
*cite journal | author=Barbuti A, Ishii S, Shimizu T, "et al." |title=Block of the background K(+) channel TASK-1 contributes to arrhythmogenic effects of platelet-activating factor. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=282 |issue= 6 |pages= H2024-30 |year= 2002 |pmid= 12003807 |doi= 10.1152/ajpheart.00956.2001
*cite journal | author=Girard C, Tinel N, Terrenoire C, "et al." |title=p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1. |journal=EMBO J. |volume=21 |issue= 17 |pages= 4439-48 |year= 2002 |pmid= 12198146 |doi=
*cite journal | author=O'Kelly I, Butler MH, Zilberberg N, Goldstein SA |title=Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals. |journal=Cell |volume=111 |issue= 4 |pages= 577-88 |year= 2002 |pmid= 12437930 |doi=
*cite journal | author=Aslamkhan A, Han YH, Walden R, "et al." |title=Stoichiometry of organic anion/dicarboxylate exchange in membrane vesicles from rat renal cortex and hOAT1-expressing cells. |journal=Am. J. Physiol. Renal Physiol. |volume=285 |issue= 4 |pages= F775-83 |year= 2003 |pmid= 12837685 |doi= 10.1152/ajprenal.00140.2003
*cite journal | author=Strebel K |title=HIV-1 Vpu: putting a channel to the TASK. |journal=Mol. Cell |volume=14 |issue= 2 |pages= 150-2 |year= 2004 |pmid= 15099514 |doi=
*cite journal | author=Hsu K, Seharaseyon J, Dong P, "et al." |title=Mutual functional destruction of HIV-1 Vpu and host TASK-1 channel. |journal=Mol. Cell |volume=14 |issue= 2 |pages= 259-67 |year= 2004 |pmid= 15099524 |doi=
*cite journal | author=Rusznák Z, Pocsai K, Kovács I, "et al." |title=Differential distribution of TASK-1, TASK-2 and TASK-3 immunoreactivities in the rat and human cerebellum. |journal=Cell. Mol. Life Sci. |volume=61 |issue= 12 |pages= 1532-42 |year= 2004 |pmid= 15197476 |doi= 10.1007/s00018-004-4082-3
*cite journal | author=Bai X, Greenwood SL, Glazier JD, "et al." |title=Localization of TASK and TREK, two-pore domain K+ channels, in human cytotrophoblast cells. |journal=J. Soc. Gynecol. Investig. |volume=12 |issue= 2 |pages= 77-83 |year= 2005 |pmid= 15695101 |doi= 10.1016/j.jsgi.2004.08.004

External links


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