GJA5

GJA5

Gap junction protein, alpha 5, 40kDa, also known as GJA5, is a human gene.

PBB_Summary
section_title =
summary_text = This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described.cite web | title = Entrez Gene: GJA5 gap junction protein, alpha 5, 40kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2702| accessdate = ]

ee also

* Connexin
* Gap junction

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Teunissen BE, Bierhuizen MF |title=Transcriptional control of myocardial connexins. |journal=Cardiovasc. Res. |volume=62 |issue= 2 |pages= 246–55 |year= 2004 |pmid= 15094345 |doi= 10.1016/j.cardiores.2003.12.011
*cite journal | author=Kanter HL, Saffitz JE, Beyer EC |title=Cardiac myocytes express multiple gap junction proteins. |journal=Circ. Res. |volume=70 |issue= 2 |pages= 438–44 |year= 1992 |pmid= 1310450 |doi=
*cite journal | author=Willecke K, Jungbluth S, Dahl E, "et al." |title=Six genes of the human connexin gene family coding for gap junctional proteins are assigned to four different human chromosomes. |journal=Eur. J. Cell Biol. |volume=53 |issue= 2 |pages= 275–80 |year= 1991 |pmid= 1964417 |doi=
*cite journal | author=Chen SC, Davis LM, Westphale EM, "et al." |title=Expression of multiple gap junction proteins in human fetal and infant hearts. |journal=Pediatr. Res. |volume=36 |issue= 5 |pages= 561–6 |year= 1995 |pmid= 7877871 |doi=
*cite journal | author=Kanter HL, Saffitz JE, Beyer EC |title=Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45. |journal=J. Mol. Cell. Cardiol. |volume=26 |issue= 7 |pages= 861–8 |year= 1994 |pmid= 7966354 |doi= 10.1006/jmcc.1994.1103
*cite journal | author=Mehta PP, Lokeshwar BL, Schiller PC, "et al." |title=Gap-junctional communication in normal and neoplastic prostate epithelial cells and its regulation by cAMP. |journal=Mol. Carcinog. |volume=15 |issue= 1 |pages= 18–32 |year= 1996 |pmid= 8561862 |doi= 10.1002/(SICI)1098-2744(199601)15:1<18::AID-MC4>3.0.CO;2-O |doilabel=10.1002/(SICI)1098-2744(199601)15:118::AID-MC43.0.CO;2-O
*cite journal | author=Gelb BD, Zhang J, Cotter PD, "et al." |title=Physical mapping of the human connexin 40 (GJA5), flavin-containing monooxygenase 5, and natriuretic peptide receptor a genes on 1q21. |journal=Genomics |volume=39 |issue= 3 |pages= 409–11 |year= 1997 |pmid= 9119381 |doi= 10.1006/geno.1996.4516
*cite journal | author=Kilarski WM, Dupont E, Coppen S, "et al." |title=Identification of two further gap-junctional proteins, connexin40 and connexin45, in human myometrial smooth muscle cells at term. |journal=Eur. J. Cell Biol. |volume=75 |issue= 1 |pages= 1–8 |year= 1998 |pmid= 9523149 |doi=
*cite journal | author=van Rijen HV, van Kempen MJ, Postma S, Jongsma HJ |title=Tumour necrosis factor alpha alters the expression of connexin43, connexin40, and connexin37 in human umbilical vein endothelial cells. |journal=Cytokine |volume=10 |issue= 4 |pages= 258–64 |year= 1998 |pmid= 9617570 |doi= 10.1006/cyto.1997.0287
*cite journal | author=Vozzi C, Dupont E, Coppen SR, "et al." |title=Chamber-related differences in connexin expression in the human heart. |journal=J. Mol. Cell. Cardiol. |volume=31 |issue= 5 |pages= 991–1003 |year= 1999 |pmid= 10336839 |doi= 10.1006/jmcc.1999.0937
*cite journal | author=Haefliger JA, Goy JJ, Waeber G |title=Sporadic cases of dilated cardiomyopathies associated with atrioventricular conduction defects are not linked to mutation within the connexins 40 and 43 genes. |journal=Eur. Heart J. |volume=20 |issue= 24 |pages= 1843 |year= 2000 |pmid= 10581143 |doi= 10.1053/euhj.1999.1718
*cite journal | author=van Rijen HV, van Veen TA, Hermans MM, Jongsma HJ |title=Human connexin40 gap junction channels are modulated by cAMP. |journal=Cardiovasc. Res. |volume=45 |issue= 4 |pages= 941–51 |year= 2000 |pmid= 10728420 |doi=
*cite journal | author=Oviedo-Orta E, Hoy T, Evans WH |title=Intercellular communication in the immune system: differential expression of connexin40 and 43, and perturbation of gap junction channel functions in peripheral blood and tonsil human lymphocyte subpopulations. |journal=Immunology |volume=99 |issue= 4 |pages= 578–90 |year= 2000 |pmid= 10792506 |doi=
*cite journal | author=Vis JC, Nicholson LF, Faull RL, "et al." |title=Connexin expression in Huntington's diseased human brain. |journal=Cell Biol. Int. |volume=22 |issue= 11-12 |pages= 837–47 |year= 2002 |pmid= 10873295 |doi= 10.1006/cbir.1998.0388
*cite journal | author=Valiunas V, Gemel J, Brink PR, Beyer EC |title=Gap junction channels formed by coexpressed connexin40 and connexin43. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=281 |issue= 4 |pages= H1675–89 |year= 2001 |pmid= 11557558 |doi=
*cite journal | author=Kaba RA, Coppen SR, Dupont E, "et al." |title=Comparison of connexin 43, 40 and 45 expression patterns in the developing human and mouse hearts. |journal=Cell Commun. Adhes. |volume=8 |issue= 4-6 |pages= 339–43 |year= 2003 |pmid= 12064615 |doi=
*cite journal | author=Cronier L, Defamie N, Dupays L, "et al." |title=Connexin expression and gap junctional intercellular communication in human first trimester trophoblast. |journal=Mol. Hum. Reprod. |volume=8 |issue= 11 |pages= 1005–13 |year= 2003 |pmid= 12397213 |doi=
*cite journal | author=Simon AM, McWhorter AR |title=Vascular abnormalities in mice lacking the endothelial gap junction proteins connexin37 and connexin40. |journal=Dev. Biol. |volume=251 |issue= 2 |pages= 206–20 |year= 2002 |pmid= 12435353 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Dupays L, Mazurais D, Rücker-Martin C, "et al." |title=Genomic organization and alternative transcripts of the human Connexin40 gene. |journal=Gene |volume=305 |issue= 1 |pages= 79–90 |year= 2003 |pmid= 12594044 |doi=

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