PRPF8

PRPF8

PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae), also known as PRPF8, is a human gene.

PBB_Summary
section_title =
summary_text = Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa.cite web | title = Entrez Gene: PRPF8 PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10594| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Grainger RJ, Beggs JD |title=Prp8 protein: at the heart of the spliceosome. |journal=RNA |volume=11 |issue= 5 |pages= 533–57 |year= 2005 |pmid= 15840809 |doi= 10.1261/rna.2220705
*cite journal | author=Garcia-Blanco MA, Anderson GJ, Beggs J, Sharp PA |title=A mammalian protein of 220 kDa binds pre-mRNAs in the spliceosome: a potential homologue of the yeast PRP8 protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 8 |pages= 3082–6 |year= 1990 |pmid= 2139226 |doi=
*cite journal | author=Pinto AL, Steitz JA |title=The mammalian analogue of the yeast PRP8 splicing protein is present in the U4/5/6 small nuclear ribonucleoprotein particle and the spliceosome. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 22 |pages= 8742–6 |year= 1989 |pmid= 2479028 |doi=
*cite journal | author=Bach M, Winkelmann G, Lührmann R |title=20S small nuclear ribonucleoprotein U5 shows a surprisingly complex protein composition. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 16 |pages= 6038–42 |year= 1989 |pmid= 2527369 |doi=
*cite journal | author=Anderson GJ, Bach M, Lührmann R, Beggs JD |title=Conservation between yeast and man of a protein associated with U5 small nuclear ribonucleoprotein. |journal=Nature |volume=342 |issue= 6251 |pages= 819–21 |year= 1990 |pmid= 2532307 |doi= 10.1038/342819a0
*cite journal | author=Umen JG, Guthrie C |title=Prp16p, Slu7p, and Prp8p interact with the 3' splice site in two distinct stages during the second catalytic step of pre-mRNA splicing. |journal=RNA |volume=1 |issue= 6 |pages= 584–97 |year= 1996 |pmid= 7489518 |doi=
*cite journal | author=Goliath R, Shugart Y, Janssens P, "et al." |title=Fine localization of the locus for autosomal dominant retinitis pigmentosa on chromosome 17p. |journal=Am. J. Hum. Genet. |volume=57 |issue= 4 |pages= 962–4 |year= 1995 |pmid= 7573060 |doi=
*cite journal | author=Greenberg J, Goliath R, Beighton P, Ramesar R |title=A new locus for autosomal dominant retinitis pigmentosa on the short arm of chromosome 17. |journal=Hum. Mol. Genet. |volume=3 |issue= 6 |pages= 915–8 |year= 1994 |pmid= 7951236 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Kojis TL, Heinzmann C, Flodman P, "et al." |title=Map refinement of locus RP13 to human chromosome 17p13.3 in a second family with autosomal dominant retinitis pigmentosa. |journal=Am. J. Hum. Genet. |volume=58 |issue= 2 |pages= 347–55 |year= 1996 |pmid= 8571961 |doi=
*cite journal | author=Reyes JL, Kois P, Konforti BB, Konarska MM |title=The canonical GU dinucleotide at the 5' splice site is recognized by p220 of the U5 snRNP within the spliceosome. |journal=RNA |volume=2 |issue= 3 |pages= 213–25 |year= 1996 |pmid= 8608445 |doi=
*cite journal | author=Hinz M, Moore MJ, Bindereif A |title=Domain analysis of human U5 RNA. Cap trimethylation, protein binding, and spliceosome assembly. |journal=J. Biol. Chem. |volume=271 |issue= 31 |pages= 19001–7 |year= 1996 |pmid= 8702566 |doi=
*cite journal | author=Chiara MD, Palandjian L, Feld Kramer R, Reed R |title=Evidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammals. |journal=EMBO J. |volume=16 |issue= 15 |pages= 4746–59 |year= 1997 |pmid= 9303319 |doi= 10.1093/emboj/16.15.4746
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Achsel T, Ahrens K, Brahms H, "et al." |title=The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein. |journal=Mol. Cell. Biol. |volume=18 |issue= 11 |pages= 6756–66 |year= 1998 |pmid= 9774689 |doi=
*cite journal | author=Reyes JL, Gustafson EH, Luo HR, "et al." |title=The C-terminal region of hPrp8 interacts with the conserved GU dinucleotide at the 5' splice site. |journal=RNA |volume=5 |issue= 2 |pages= 167–79 |year= 1999 |pmid= 10024169 |doi=
*cite journal | author=Luo HR, Moreau GA, Levin N, Moore MJ |title=The human Prp8 protein is a component of both U2- and U12-dependent spliceosomes. |journal=RNA |volume=5 |issue= 7 |pages= 893–908 |year= 1999 |pmid= 10411133 |doi=
*cite journal | author=Makarov EM, Makarova OV, Achsel T, Lührmann R |title=The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions. |journal=J. Mol. Biol. |volume=298 |issue= 4 |pages= 567–75 |year= 2000 |pmid= 10788320 |doi= 10.1006/jmbi.2000.3685
*cite journal | author=Le Hir H, Moore MJ, Maquat LE |title=Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions. |journal=Genes Dev. |volume=14 |issue= 9 |pages= 1098–108 |year= 2000 |pmid= 10809668 |doi=
*cite journal | author=McHale JC, McKie AB, Tarttelin EE, Inglehearn CF |title=Expression map of human chromosome region 17p13.3, spanning the RP13 dominant retinitis pigmentosa locus, the Miller-Dieker lissencephaly syndrome (MDLS) region, and a putative tumour suppressor locus. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 225–9 |year= 2000 |pmid= 10828595 |doi=

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