CLCA1

Chloride channel, calcium activated, family member 1, also known as CLCA1, is a human gene.cite web | title = Entrez Gene: CLCA1 chloride channel, calcium activated, family member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1179| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.cite web | title = Entrez Gene: CLCA1 chloride channel, calcium activated, family member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1179| accessdate = ]

ee also

* Chloride channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hume JR, Duan D, Collier ML, "et al." |title=Anion transport in heart. |journal=Physiol. Rev. |volume=80 |issue= 1 |pages= 31–81 |year= 2000 |pmid= 10617765 |doi=
*cite journal | author=Pauli BU, Abdel-Ghany M, Cheng HC, "et al." |title=Molecular characteristics and functional diversity of CLCA family members. |journal=Clin. Exp. Pharmacol. Physiol. |volume=27 |issue= 11 |pages= 901–5 |year= 2001 |pmid= 11071307 |doi=
*cite journal | author=Gruber AD, Elble RC, Ji HL, "et al." |title=Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel proteins. |journal=Genomics |volume=54 |issue= 2 |pages= 200–14 |year= 1999 |pmid= 9828122 |doi= 10.1006/geno.1998.5562
*cite journal | author=Agnel M, Vermat T, Culouscou JM |title=Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea. |journal=FEBS Lett. |volume=455 |issue= 3 |pages= 295–301 |year= 1999 |pmid= 10437792 |doi=
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Liu QH, Williams DA, McManus C, "et al." |title=HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4832–7 |year= 2000 |pmid= 10758170 |doi= 10.1073/pnas.090521697
*cite journal | author=Toda M, Tulic MK, Levitt RC, Hamid Q |title=A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma. |journal=J. Allergy Clin. Immunol. |volume=109 |issue= 2 |pages= 246–50 |year= 2002 |pmid= 11842292 |doi=
*cite journal | author=Greenwood IA, Miller LJ, Ohya S, Horowitz B |title=The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22119–22 |year= 2002 |pmid= 11994272 |doi= 10.1074/jbc.C200215200
*cite journal | author=Abdel-Ghany M, Cheng HC, Elble RC, Pauli BU |title=Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth. |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 34391–400 |year= 2002 |pmid= 12110680 |doi= 10.1074/jbc.M205307200
*cite journal | author=Loewen ME, Bekar LK, Gabriel SE, "et al." |title=pCLCA1 becomes a cAMP-dependent chloride conductance mediator in Caco-2 cells. |journal=Biochem. Biophys. Res. Commun. |volume=298 |issue= 4 |pages= 531–6 |year= 2002 |pmid= 12408984 |doi=
*cite journal | author=Zhou Y, Shapiro M, Dong Q, "et al." |title=A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction. |journal=Novartis Found. Symp. |volume=248 |issue= |pages= 150–65; discussion 165–70, 277–82 |year= 2003 |pmid= 12568493 |doi=
*cite journal | author=Abdel-Ghany M, Cheng HC, Elble RC, "et al." |title=The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis. |journal=J. Biol. Chem. |volume=278 |issue= 49 |pages= 49406–16 |year= 2004 |pmid= 14512419 |doi= 10.1074/jbc.M309086200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Hegab AE, Sakamoto T, Uchida Y, "et al." |title=CLCA1 gene polymorphisms in chronic obstructive pulmonary disease. |journal=J. Med. Genet. |volume=41 |issue= 3 |pages= e27 |year= 2004 |pmid= 14985398 |doi=
*cite journal | author=Kamada F, Suzuki Y, Shao C, "et al." |title=Association of the hCLCA1 gene with childhood and adult asthma. |journal=Genes Immun. |volume=5 |issue= 7 |pages= 540–7 |year= 2005 |pmid= 15318163 |doi= 10.1038/sj.gene.6364124
*cite journal | author=Ritzka M, Stanke F, Jansen S, "et al." |title=The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis. |journal=Hum. Genet. |volume=115 |issue= 6 |pages= 483–91 |year= 2005 |pmid= 15490240 |doi= 10.1007/s00439-004-1190-y
*cite journal | author=Gibson A, Lewis AP, Affleck K, "et al." |title=hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels. |journal=J. Biol. Chem. |volume=280 |issue= 29 |pages= 27205–12 |year= 2005 |pmid= 15919655 |doi= 10.1074/jbc.M504654200
*cite journal | author=Jeong SM, Park HK, Yoon IS, "et al." |title=Cloning and expression of Ca2+-activated chloride channel from rat brain. |journal=Biochem. Biophys. Res. Commun. |volume=334 |issue= 2 |pages= 569–76 |year= 2005 |pmid= 16023076 |doi= 10.1016/j.bbrc.2005.06.122

External links

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