KCNMB1

Potassium large conductance calcium-activated channel, subfamily M, beta member 1, also known as KCNMB1, is a human gene.cite web | title = Entrez Gene: KCNMB1 potassium large conductance calcium-activated channel, subfamily M, beta member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3779| accessdate = ]

PBB_Summary
section_title =
summary_text = MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits.cite web | title = Entrez Gene: KCNMB1 potassium large conductance calcium-activated channel, subfamily M, beta member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3779| accessdate = ]

ee also

* BK channel
* Voltage-gated potassium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Orio P, Rojas P, Ferreira G, Latorre R |title=New disguises for an old channel: MaxiK channel beta-subunits. |journal=News Physiol. Sci. |volume=17 |issue= |pages= 156–61 |year= 2002 |pmid= 12136044 |doi=
*cite journal | author=Knaus HG, Folander K, Garcia-Calvo M, "et al." |title=Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle. |journal=J. Biol. Chem. |volume=269 |issue= 25 |pages= 17274–8 |year= 1994 |pmid= 8006036 |doi=
*cite journal | author=Meera P, Wallner M, Jiang Z, Toro L |title=A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV,Ca beta) of maxi K channels. |journal=FEBS Lett. |volume=382 |issue= 1-2 |pages= 84–8 |year= 1996 |pmid= 8612769 |doi=
*cite journal | author=Dworetzky SI, Boissard CG, Lum-Ragan JT, "et al." |title=Phenotypic alteration of a human BK (hSlo) channel by hSlobeta subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation. |journal=J. Neurosci. |volume=16 |issue= 15 |pages= 4543–50 |year= 1996 |pmid= 8764643 |doi=
*cite journal | author=Tseng-Crank J, Godinot N, Johansen TE, "et al." |title=Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 17 |pages= 9200–5 |year= 1996 |pmid= 8799178 |doi=
*cite journal | author=Jiang Z, Wallner M, Meera P, Toro L |title=Human and rodent MaxiK channel beta-subunit genes: cloning and characterization. |journal=Genomics |volume=55 |issue= 1 |pages= 57–67 |year= 1999 |pmid= 9888999 |doi= 10.1006/geno.1998.5627
*cite journal | author=Valverde MA, Rojas P, Amigo J, "et al." |title=Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit. |journal=Science |volume=285 |issue= 5435 |pages= 1929–31 |year= 1999 |pmid= 10489376 |doi=
*cite journal | author=Meera P, Wallner M, Toro L |title=A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 10 |pages= 5562–7 |year= 2000 |pmid= 10792058 |doi= 10.1073/pnas.100118597
*cite journal | author=Jin P, Weiger TM, Wu Y, Levitan IB |title=Phosphorylation-dependent functional coupling of hSlo calcium-dependent potassium channel and its hbeta 4 subunit. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10014–20 |year= 2002 |pmid= 11790768 |doi= 10.1074/jbc.M107682200
*cite journal | author=Greenwood IA, Miller LJ, Ohya S, Horowitz B |title=The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22119–22 |year= 2002 |pmid= 11994272 |doi= 10.1074/jbc.C200215200
*cite journal | author=Gollasch M, Tank J, Luft FC, "et al." |title=The BK channel beta1 subunit gene is associated with human baroreflex and blood pressure regulation. |journal=J. Hypertens. |volume=20 |issue= 5 |pages= 927–33 |year= 2002 |pmid= 12011654 |doi=
*cite journal | author=Jin P, Weiger TM, Levitan IB |title=Reciprocal modulation between the alpha and beta 4 subunits of hSlo calcium-dependent potassium channels. |journal=J. Biol. Chem. |volume=277 |issue= 46 |pages= 43724–9 |year= 2003 |pmid= 12223479 |doi= 10.1074/jbc.M205795200
*cite journal | author=Mazzone JN, Kaiser RA, Buxton IL |title=Calcium-activated potassium channel expression in human myometrium: effect of pregnancy. |journal=Proc. West. Pharmacol. Soc. |volume=45 |issue= |pages= 184–6 |year= 2003 |pmid= 12434576 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kudlacek PE, Pluznick JL, Ma R, "et al." |title=Role of hbeta1 in activation of human mesangial BK channels by cGMP kinase. |journal=Am. J. Physiol. Renal Physiol. |volume=285 |issue= 2 |pages= F289–94 |year= 2003 |pmid= 12670831 |doi= 10.1152/ajprenal.00046.2003
*cite journal | author=Qian X, Magleby KL |title=Beta1 subunits facilitate gating of BK channels by acting through the Ca2+, but not the Mg2+, activating mechanisms. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 17 |pages= 10061–6 |year= 2003 |pmid= 12893878 |doi= 10.1073/pnas.1731650100
*cite journal | author=Ransom CB, Liu X, Sontheimer H |title=Current transients associated with BK channels in human glioma cells. |journal=J. Membr. Biol. |volume=193 |issue= 3 |pages= 201–13 |year= 2004 |pmid= 12962281 |doi= 10.1007/s00232-003-2019-7
*cite journal | author=Hartness ME, Brazier SP, Peers C, "et al." |title=Post-transcriptional control of human maxiK potassium channel activity and acute oxygen sensitivity by chronic hypoxia. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51422–32 |year= 2004 |pmid= 14522958 |doi= 10.1074/jbc.M309463200
*cite journal | author=Fernández-Fernández JM, Tomás M, Vázquez E, "et al." |title=Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension. |journal=J. Clin. Invest. |volume=113 |issue= 7 |pages= 1032–9 |year= 2004 |pmid= 15057310 |doi= 10.1172/JCI200420347

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