CLCNKA

Chloride channel Ka, also known as CLCNKA, is a human gene.cite web | title = Entrez Gene: CLCNKA chloride channel Ka| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1187| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: CLCNKA chloride channel Ka| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1187| accessdate = ]

ee also

* Chloride channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Jentsch TJ, Günther W |title=Chloride channels: an emerging molecular picture. |journal=Bioessays |volume=19 |issue= 2 |pages= 117–26 |year= 1997 |pmid= 9046241 |doi= 10.1002/bies.950190206
*cite journal | author=Kieferle S, Fong P, Bens M, "et al." |title=Two highly homologous members of the ClC chloride channel family in both rat and human kidney. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 15 |pages= 6943–7 |year= 1994 |pmid= 8041726 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Takeuchi Y, Uchida S, Marumo F, Sasaki S |title=Cloning, tissue distribution, and intrarenal localization of ClC chloride channels in human kidney. |journal=Kidney Int. |volume=48 |issue= 5 |pages= 1497–503 |year= 1996 |pmid= 8544406 |doi=
*cite journal | author=Saito-Ohara F, Uchida S, Takeuchi Y, "et al." |title=Assignment of the genes encoding the human chloride channels, CLCNKA and CLCNKB, to 1p36 and of CLCN3 to 4q32-q33 by in situ hybridization. |journal=Genomics |volume=36 |issue= 2 |pages= 372–4 |year= 1997 |pmid= 8812470 |doi= 10.1006/geno.1996.0479
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Estévez R, Boettger T, Stein V, "et al." |title=Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion. |journal=Nature |volume=414 |issue= 6863 |pages= 558–61 |year= 2002 |pmid= 11734858 |doi= 10.1038/35107099
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Schlingmann KP, Konrad M, Jeck N, "et al." |title=Salt wasting and deafness resulting from mutations in two chloride channels. |journal=N. Engl. J. Med. |volume=350 |issue= 13 |pages= 1314–9 |year= 2004 |pmid= 15044642 |doi= 10.1056/NEJMoa032843
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Scholl U, Hebeisen S, Janssen AG, "et al." |title=Barttin modulates trafficking and function of ClC-K channels. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 30 |pages= 11411–6 |year= 2006 |pmid= 16849430 |doi= 10.1073/pnas.0601631103
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Barlassina C, Dal Fiume C, Lanzani C, "et al." |title=Common genetic variants and haplotypes in renal CLCNKA gene are associated to salt-sensitive hypertension. |journal=Hum. Mol. Genet. |volume=16 |issue= 13 |pages= 1630–8 |year= 2007 |pmid= 17510212 |doi= 10.1093/hmg/ddm112
*cite journal | author=Markovic S, Dutzler R |title=The structure of the cytoplasmic domain of the chloride channel ClC-Ka reveals a conserved interaction interface. |journal=Structure |volume=15 |issue= 6 |pages= 715–25 |year= 2007 |pmid= 17562318 |doi= 10.1016/j.str.2007.04.013

External links

*

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