KCNB1

Potassium voltage-gated channel, Shab-related subfamily, member 1, also known as KCNB1 or K_v2.1, is a human gene.cite web | title = Entrez Gene: KCNB1 potassium voltage-gated channel, Shab-related subfamily, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3745| accessdate = ]

PBB_Summary
section_title =
summary_text = Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members.cite web | title = Entrez Gene: KCNB1 potassium voltage-gated channel, Shab-related subfamily, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3745| accessdate = ]

ee also

* Voltage-gated potassium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gutman GA, Chandy KG, Grissmer S, "et al." |title=International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 473–508 |year= 2006 |pmid= 16382104 |doi= 10.1124/pr.57.4.10
*cite journal | author=Melis R, Stauffer D, Zhao X, "et al." |title=Physical and genetic localization of a Shab subfamily potassium channel (KCNB1) gene to chromosomal region 20q13.2. |journal=Genomics |volume=25 |issue= 1 |pages= 285–7 |year= 1995 |pmid= 7774931 |doi=
*cite journal | author=Albrecht B, Lorra C, Stocker M, Pongs O |title=Cloning and characterization of a human delayed rectifier potassium channel gene. |journal=Recept. Channels |volume=1 |issue= 2 |pages= 99–110 |year= 1994 |pmid= 8081723 |doi=
*cite journal | author=Hugnot JP, Salinas M, Lesage F, "et al." |title=Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels. |journal=EMBO J. |volume=15 |issue= 13 |pages= 3322–31 |year= 1996 |pmid= 8670833 |doi=
*cite journal | author=Post MA, Kirsch GE, Brown AM |title=Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current. |journal=FEBS Lett. |volume=399 |issue= 1-2 |pages= 177–82 |year= 1997 |pmid= 8980147 |doi=
*cite journal | author=Patel AJ, Lazdunski M, Honoré E |title=Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes. |journal=EMBO J. |volume=16 |issue= 22 |pages= 6615–25 |year= 1998 |pmid= 9362476 |doi= 10.1093/emboj/16.22.6615
*cite journal | author=Shepard AR, Rae JL |title=Electrically silent potassium channel subunits from human lens epithelium. |journal=Am. J. Physiol. |volume=277 |issue= 3 Pt 1 |pages= C412–24 |year= 1999 |pmid= 10484328 |doi=
*cite journal | author=Zhu XR, Netzer R, Böhlke K, "et al." |title=Structural and functional characterization of Kv6.2 a new gamma-subunit of voltage-gated potassium channel. |journal=Recept. Channels |volume=6 |issue= 5 |pages= 337–50 |year= 1999 |pmid= 10551266 |doi=
*cite journal | author=Peretz A, Gil-Henn H, Sobko A, "et al." |title=Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon. |journal=EMBO J. |volume=19 |issue= 15 |pages= 4036–45 |year= 2000 |pmid= 10921884 |doi= 10.1093/emboj/19.15.4036
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Sano Y, Mochizuki S, Miyake A, "et al." |title=Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1. |journal=FEBS Lett. |volume=512 |issue= 1-3 |pages= 230–4 |year= 2002 |pmid= 11852086 |doi=
*cite journal | author=Kurata HT, Soon GS, Eldstrom JR, "et al." |title=Amino-terminal determinants of U-type inactivation of voltage-gated K+ channels. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 29045–53 |year= 2002 |pmid= 12021261 |doi= 10.1074/jbc.M111470200
*cite journal | author=Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ |title=Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 12 |pages= 7986–91 |year= 2002 |pmid= 12060745 |doi= 10.1073/pnas.122617999
*cite journal | author=MacDonald PE, Wang G, Tsuk S, "et al." |title=Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus. |journal=Mol. Endocrinol. |volume=16 |issue= 11 |pages= 2452–61 |year= 2003 |pmid= 12403834 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ju M, Stevens L, Leadbitter E, Wray D |title=The Roles of N- and C-terminal determinants in the activation of the Kv2.1 potassium channel. |journal=J. Biol. Chem. |volume=278 |issue= 15 |pages= 12769–78 |year= 2003 |pmid= 12560340 |doi= 10.1074/jbc.M212973200
*cite journal | author=Tiran Z, Peretz A, Attali B, Elson A |title=Phosphorylation-dependent regulation of Kv2.1 Channel activity at tyrosine 124 by Src and by protein-tyrosine phosphatase epsilon. |journal=J. Biol. Chem. |volume=278 |issue= 19 |pages= 17509–14 |year= 2003 |pmid= 12615930 |doi= 10.1074/jbc.M212766200
*cite journal | author=Consiglio JF, Korn SJ |title=Influence of permeant ions on voltage sensor function in the Kv2.1 potassium channel. |journal=J. Gen. Physiol. |volume=123 |issue= 4 |pages= 387–400 |year= 2004 |pmid= 15024041 |doi= 10.1085/jgp.200308976
*cite journal | author=Thébaud B, Michelakis ED, Wu XC, "et al." |title=Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus. |journal=Circulation |volume=110 |issue= 11 |pages= 1372–9 |year= 2005 |pmid= 15353504 |doi= 10.1161/01.CIR.0000141292.28616.65
*cite journal | author=Kerschensteiner D, Soto F, Stocker M |title=Fluorescence measurements reveal stoichiometry of K+ channels formed by modulatory and delayed rectifier alpha-subunits. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 17 |pages= 6160–5 |year= 2005 |pmid= 15827117 |doi= 10.1073/pnas.0500468102

External links

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