P-type calcium channel

P-type calcium channel: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

Identifiers

Symbol CACNA1A

Alt. symbols Cav2.1, CACNL1A4, SCA6, MHP1, MHP

IUPHAR Ca_v2.1

Entrez 773

HUGO 1388

OMIM 601011

RefSeq NM_000068

UniProt O00555

Other data

Locus Chr. 19 p13

The p-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit is the one that determines most of the channel's properties.

P-type ('P' for cerebellar Purkinje cells) calcium channels play a similar role to the N-type calcium channel in neurotransmitter release at the presynaptic terminal, and in neuronal integration in many neuronal types.

They are also found in Purkinje fibers in the electrical conduction system of the heart. Their properties are less well understood.

P channels were discovered in cerebellar Purkinje cells by Llinas and Sugimori^[1] and named P channels by Llinas et al.^[2]

References

^ Llinás R, Sugimori M (1980). "Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices". J. Physiol. (Lond.) 305: 171–95. PMC 1282966. PMID 7441552. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1282966.

^ Llinás R, Sugimori M, Lin JW, Cherksey B (1989). "Blocking and isolation of a calcium channel from neurons in mammals and cephalopods utilizing a toxin fraction (FTX) from funnel-web spider poison". Proc. Natl. Acad. Sci. U.S.A. 86 (5): 1689–93. doi:10.1073/pnas.86.5.1689. PMC 286766. PMID 2537980. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=286766.

External links

MeSH P-Type+Calcium+Channel

v · Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Voltage-gated

L-type/Ca_vα (1.1, 1.2, 1.3, 1.4) · N-type/Ca_vα2.2 · P-type/Ca_vα(2.1) · Q-type/Ca_vα2.1 · R-type/Ca_vα2.3 · T-type/Ca_vα(3.1, 3.2, 3.3)
α₂δ-subunits (1, 2) · β-subunits (β1, β2, β3, β4) · γ-subunits (γ1, γ2, γ3, γ4)
Cation channels of sperm (1, 2, 3, 4) · Two-pore channel (1, 2)

Ligand-gated

Inositol trisphosphate receptor (1, 2, 3) · Ryanodine receptor (1, 2, 3)

Na⁺: Sodium channel

Constitutively active

Epithelial sodium channel (α, β, γ, δ)

Proton gated

Amiloride-sensitive cation channel (1, 2, 3, 4)

Voltage-gated

Na_vα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 7A) · Na_vβ (1, 2, 3, 4)

K⁺: Potassium channel

Voltage-gated

K_vα1-6 (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8) · (2.1, 2.2) · (3.1, 3.2, 3.3, 3.4) · (4.1, 4.2, 4.3) · (5.1) · (6.1, 6.2, 6.3, 6.4)
K_vα7-12 (7.1, 7.2, 7.3, 7.4, 7.5) · (8.1, 8.2) · (9.1, 9.2, 9.3) · (10.1, 10.2) · (11.1/hERG, 11.2, 11.3) · (12.1, 12.2, 12.3)
K_vβ (1, 2, 3) · KCNIP (1, 2, 3, 4) · minK/ISK · minK/ISK-like · MiRP (1, 2, 3) · Shaker gene

Calcium-activated

BK channel (α1, β1, β2, β3, β4) · SK channel (SK1, SK2, SK3, SK4) · K_Ca (1.1, 2.1, 2.2, 2.3, 3.1, 4.1, 4.2, 5.1)

Inward-rectifier

K_ATP · K_ir (1.1, 2.1, 2.2, 2.3, 2.4, 2.6) · GIRK/K_ir (3.1, 3.2, 3.3, 3.4) · K_ir (4.1, 4.2, 5.1, 6.1, 6.2, 7.1)

Tandem pore domain

K2P (1, 2, 3, 4, 5, 6, 7, 9, 10, 12, 13, 15, 16, 17, 18)

Other

Cl^-: Chloride channel

ANO1 · Bestrophin (1, 2) · CFTR · CLCA (1, 2, 3, 4) · CLCN (1, 2, 3, 4, 5, 6, 7, KA, KB) · CLIC (1, 2, 3, 4, 5, 6, L1) · CLNS (1A, 1B)

H⁺: Voltage-gated

HVCN1

M⁺: TRP cation channel

TRPA (1) · TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) · TRPM (1, 2, 3, 4, 5, 6, 7, 8) · TRPML (1, 2, 3) · TRPP (1, 2) · TRPV (1, 2, 3, 4, 5, 6)

Cyclic nucleotide-gated (FC)

α (1, 2, 3, 4) · β (1, 2, 3) · HCN (1, 2, 3, 4)

Porin

Aquaporin (1, 2, 3, 4, 5, 7, 8, 9) · Voltage-dependent anion channel (1, 2, 3) · General bacterial porin family

Gap junction

Connexin: A (GJA1, GJA3, GJA4, GJA5, GJA8, GJA9, GJA10) · B (GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7) · C (GJC1, GJC2, GJC3) · D (GJD2, GJD3, GJD4))
Innexin

General

Ligand-gated ion channel · Voltage-gated ion channel · Stretch-activated ion channel

see also disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), othr

Categories:
Genes on chromosome 19
Ion channels
Electrophysiology
Membrane biology
Integral membrane proteins

calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Identifiers
Symbol	CACNA1A
Alt. symbols	Cav2.1, CACNL1A4, SCA6, MHP1, MHP
IUPHAR	Ca_v2.1
Entrez	773
HUGO	1388
OMIM	601011
RefSeq	NM_000068
UniProt	O00555
Other data
Locus	Chr. 19 p13

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N-type calcium channel — Calcium channel, voltage dependent, N type, alpha 1B subunit Identifiers Symbols CACNA1B; BIII; CACNL1A5; CACNN; Cav2.2 External IDs … Wikipedia
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P-type calcium channel

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