P-type calcium channel

P-type calcium channel
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Identifiers
Symbol CACNA1A
Alt. symbols Cav2.1, CACNL1A4, SCA6, MHP1, MHP
IUPHAR Cav2.1
Entrez 773
HUGO 1388
OMIM 601011
RefSeq NM_000068
UniProt O00555
Other data
Locus Chr. 19 p13

The p-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit is the one that determines most of the channel's properties.

P-type ('P' for cerebellar Purkinje cells) calcium channels play a similar role to the N-type calcium channel in neurotransmitter release at the presynaptic terminal, and in neuronal integration in many neuronal types.

They are also found in Purkinje fibers in the electrical conduction system of the heart. Their properties are less well understood.

P channels were discovered in cerebellar Purkinje cells by Llinas and Sugimori[1] and named P channels by Llinas et al.[2]

References

External links


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