TRPV6

TRPV6 is a membrane calcium channel which is responsible for the first step in calcium absorption in the and the calcium-pumping ATPAse are also found. The TRPV6 calcium transporter also found in the human placenta, pancreas and prostate gland and in some species in the kidney where the related channel TRPV5 is strongly expressed.

TRPV6 is a member of the Transient receptor potential family of membrane proteins.

Expression of TRPV6 appears to be vitamin D dependent as it is greatly reduced in animals that do not express the vitamin D receptor. Importantly, vitamin D treatment of colon cancer cells, Caco-2, also increases expression of "TRPV6" gene. Vitamin D treatment of these cells also increases transport of calcium, probably via increasing TRPV6 expression.

ee also

* TRPV

References

Further reading

*cite journal |author=Taparia S, Fleet JC, Peng JB, Wang XD, Wood RJ |title=1,25-Dihydroxyvitamin D and 25-hydroxyvitamin D--mediated regulation of TRPV6 (a putative epithelial calcium channel) mRNA expression in Caco-2 cells |journal=European journal of nutrition |volume=45 |issue=4 |pages=196–204 |year=2006 |pmid=16362534 |doi=10.1007/s00394-005-0586-3PBB_Further_reading
citations =
*cite journal | author=Heiner I, Eisfeld J, Lückhoff A |title=Role and regulation of TRP channels in neutrophil granulocytes. |journal=Cell Calcium |volume=33 |issue= 5-6 |pages= 533–40 |year= 2004 |pmid= 12765698 |doi=
*cite journal | author=Peng JB, Brown EM, Hediger MA |title=Epithelial Ca2+ entry channels: transcellular Ca2+ transport and beyond. |journal=J. Physiol. (Lond.) |volume=551 |issue= Pt 3 |pages= 729–40 |year= 2004 |pmid= 12869611 |doi= 10.1113/jphysiol.2003.043349
*cite journal | author=Clapham DE, Julius D, Montell C, Schultz G |title=International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 427–50 |year= 2006 |pmid= 16382100 |doi= 10.1124/pr.57.4.6
*cite journal | author=Wissenbach U, Niemeyer BA |title=TRPV6. |journal=Handb Exp Pharmacol |volume= |issue= 179 |pages= 221–34 |year= 2007 |pmid= 17217060 |doi= 10.1007/978-3-540-34891-7_13
*cite journal | author=Schoeber JP, Hoenderop JG, Bindels RJ |title=Concerted action of associated proteins in the regulation of TRPV5 and TRPV6. |journal=Biochem. Soc. Trans. |volume=35 |issue= Pt 1 |pages= 115–9 |year= 2007 |pmid= 17233615 |doi= 10.1042/BST0350115

External links

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