- Cav1.2
Calcium channel, voltage-dependent, L type, alpha 1C subunit (also known as Cav1.2) is a subunit of L-type
voltage-dependent calcium channel encoded by the gene|CACNA1C gene, mutation in which are associated with a variant ofLong QT syndrome calledTimothy's syndrome and also withBrugada syndrome . A large-scale genetic analysis conducted in 2008 shows the possibility that CACNA1C is associated withbipolar disorder . Ferreira MAR and 62 others. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat. Genet., published online 17 August, 2008.] [http://www.schizophreniaforum.org/new/detail.asp?id=1450 Channeling Mental Illness: GWAS Links Ion Channels, Bipolar Disorder] - 19 aug 2008, Schizophrenia Research Forum, covered by Peter Farley]ee also
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Calcium channel References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J |title=International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 411–25 |year= 2006 |pmid= 16382099 |doi= 10.1124/pr.57.4.5
*cite journal | author=Soldatov NM |title=Molecular diversity of L-type Ca2+ channel transcripts in human fibroblasts. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 10 |pages= 4628–32 |year= 1992 |pmid= 1316612 |doi=
*cite journal | author=Powers PA, Gregg RG, Hogan K |title=Linkage mapping of the human gene for the alpha 1 subunit of the cardiac DHP-sensitive Ca2+ channel (CACNL1A1) to chromosome 12p13.2-pter using a dinucleotide repeat. |journal=Genomics |volume=14 |issue= 1 |pages= 206–7 |year= 1992 |pmid= 1330882 |doi=
*cite journal | author=Sun W, McPherson JD, Hoang DQ, "et al." |title=Mapping of a human brain voltage-gated calcium channel to human chromosome 12p13-pter. |journal=Genomics |volume=14 |issue= 4 |pages= 1092–4 |year= 1993 |pmid= 1335957 |doi=
*cite journal | author=Lacerda AE, Kim HS, Ruth P, "et al." |title=Normalization of current kinetics by interaction between the alpha 1 and beta subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel. |journal=Nature |volume=352 |issue= 6335 |pages= 527–30 |year= 1991 |pmid= 1650913 |doi= 10.1038/352527a0
*cite journal | author=Powers PA, Gregg RG, Lalley PA, "et al." |title=Assignment of the human gene for the alpha 1 subunit of the cardiac DHP-sensitive Ca2+ channel (CCHL1A1) to chromosome 12p12-pter. |journal=Genomics |volume=10 |issue= 3 |pages= 835–9 |year= 1991 |pmid= 1653763 |doi=
*cite journal | author=Perez-Reyes E, Wei XY, Castellano A, Birnbaumer L |title=Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes. |journal=J. Biol. Chem. |volume=265 |issue= 33 |pages= 20430–6 |year= 1990 |pmid= 2173707 |doi=
*cite journal | author=Soldatov NM, Bouron A, Reuter H |title=Different voltage-dependent inhibition by dihydropyridines of human Ca2+ channel splice variants. |journal=J. Biol. Chem. |volume=270 |issue= 18 |pages= 10540–3 |year= 1995 |pmid= 7737988 |doi=
*cite journal | author=Soldatov NM |title=Genomic structure of human L-type Ca2+ channel. |journal=Genomics |volume=22 |issue= 1 |pages= 77–87 |year= 1994 |pmid= 7959794 |doi= 10.1006/geno.1994.1347
*cite journal | author=Tang S, Mikala G, Bahinski A, "et al." |title=Molecular localization of ion selectivity sites within the pore of a human L-type cardiac calcium channel. |journal=J. Biol. Chem. |volume=268 |issue= 18 |pages= 13026–9 |year= 1993 |pmid= 8099908 |doi=
*cite journal | author=Schultz D, Mikala G, Yatani A, "et al." |title=Cloning, chromosomal localization, and functional expression of the alpha 1 subunit of the L-type voltage-dependent calcium channel from normal human heart. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 13 |pages= 6228–32 |year= 1993 |pmid= 8392192 |doi=
*cite journal |author=Perets T, Blumenstein Y, Shistik E, "et al." |title=A potential site of functional modulation by protein kinase A in the cardiac Ca2+ channel alpha 1C subunit. |journal=FEBS Lett. |volume=384 |issue= 2 |pages= 189–92 |year= 1996 |pmid= 8612821 |doi=
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Soldatov NM, Zühlke RD, Bouron A, Reuter H |title=Molecular structures involved in L-type calcium channel inactivation. Role of the carboxyl-terminal region encoded by exons 40-42 in alpha1C subunit in the kinetics and Ca2+ dependence of inactivation. |journal=J. Biol. Chem. |volume=272 |issue= 6 |pages= 3560–6 |year= 1997 |pmid= 9013606 |doi=
*cite journal | author=Klöckner U, Mikala G, Eisfeld J, "et al." |title=Properties of three COOH-terminal splice variants of a human cardiac L-type Ca2+-channel alpha1-subunit. |journal=Am. J. Physiol. |volume=272 |issue= 3 Pt 2 |pages= H1372–81 |year= 1997 |pmid= 9087614 |doi=
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Gao T, Yatani A, Dell'Acqua ML, "et al." |title=cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits. |journal=Neuron |volume=19 |issue= 1 |pages= 185–96 |year= 1997 |pmid= 9247274 |doi=
*cite journal | author=Zühlke RD, Bouron A, Soldatov NM, Reuter H |title=Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human alpha1C subunit gene. |journal=FEBS Lett. |volume=427 |issue= 2 |pages= 220–4 |year= 1998 |pmid= 9607315 |doi=
*cite journal | author=Meyers MB, Puri TS, Chien AJ, "et al." |title=Sorcin associates with the pore-forming subunit of voltage-dependent L-type Ca2+ channels. |journal=J. Biol. Chem. |volume=273 |issue= 30 |pages= 18930–5 |year= 1998 |pmid= 9668070 |doi=
*cite journal | author=Liu WS, Soldatov NM, Gustavsson I, Chowdhary BP |title=Fiber-FISH analysis of the 3'-terminal region of the human L-type Ca2+ channel alpha 1C subunit gene. |journal=Hereditas |volume=129 |issue= 2 |pages= 169–75 |year= 1999 |pmid= 10022083 |doi=External links
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