KCNH1

Potassium voltage-gated channel, subfamily H (eag-related), member 1, also known as KCNH1 or K_v10.1, is a human gene.cite web | title = Entrez Gene: KCNH1 potassium voltage-gated channel, subfamily H (eag-related), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3756| accessdate = ]

PBB_Summary
section_title =
summary_text = Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.cite web | title = Entrez Gene: KCNH1 potassium voltage-gated channel, subfamily H (eag-related), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3756| accessdate = ]

ee also

* Voltage-gated potassium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gutman GA, Chandy KG, Grissmer S, "et al." |title=International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 473–508 |year= 2006 |pmid= 16382104 |doi= 10.1124/pr.57.4.10
*cite journal | author=Warmke JW, Ganetzky B |title=A family of potassium channel genes related to eag in Drosophila and mammals. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 8 |pages= 3438–42 |year= 1994 |pmid= 8159766 |doi=
*cite journal | author=Hoshi N, Takahashi H, Shahidullah M, "et al." |title=KCR1, a membrane protein that facilitates functional expression of non-inactivating K+ currents associates with rat EAG voltage-dependent K+ channels. |journal=J. Biol. Chem. |volume=273 |issue= 36 |pages= 23080–5 |year= 1998 |pmid= 9722534 |doi=
*cite journal | author=Occhiodoro T, Bernheim L, Liu JH, "et al." |title=Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion. |journal=FEBS Lett. |volume=434 |issue= 1-2 |pages= 177–82 |year= 1998 |pmid= 9738473 |doi=
*cite journal | author=Pardo LA, del Camino D, Sánchez A, "et al." |title=Oncogenic potential of EAG K(+) channels. |journal=EMBO J. |volume=18 |issue= 20 |pages= 5540–7 |year= 1999 |pmid= 10523298 |doi= 10.1093/emboj/18.20.5540
*cite journal | author=Schönherr R, Löber K, Heinemann SH |title=Inhibition of human ether à go-go potassium channels by Ca(2+)/calmodulin. |journal=EMBO J. |volume=19 |issue= 13 |pages= 3263–71 |year= 2000 |pmid= 10880439 |doi= 10.1093/emboj/19.13.3263
*cite journal | author=Cayabyab FS, Schlichter LC |title=Regulation of an ERG K+ current by Src tyrosine kinase. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13673–81 |year= 2002 |pmid= 11834728 |doi= 10.1074/jbc.M108211200
*cite journal | author=Schönherr R, Gessner G, Löber K, Heinemann SH |title=Functional distinction of human EAG1 and EAG2 potassium channels. |journal=FEBS Lett. |volume=514 |issue= 2-3 |pages= 204–8 |year= 2002 |pmid= 11943152 |doi=
*cite journal | author=Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ |title=Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 12 |pages= 7986–91 |year= 2002 |pmid= 12060745 |doi= 10.1073/pnas.122617999
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Farias LM, Ocaña DB, Díaz L, "et al." |title=Ether a go-go potassium channels as human cervical cancer markers. |journal=Cancer Res. |volume=64 |issue= 19 |pages= 6996–7001 |year= 2004 |pmid= 15466192 |doi= 10.1158/0008-5472.CAN-04-1204
*cite journal | author=Kang J, Chen XL, Wang H, "et al." |title=Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel. |journal=Mol. Pharmacol. |volume=67 |issue= 3 |pages= 827–36 |year= 2005 |pmid= 15548764 |doi= 10.1124/mol.104.006577
*cite journal | author=Ziechner U, Schönherr R, Born AK, "et al." |title=Inhibition of human ether à go-go potassium channels by Ca2+/calmodulin binding to the cytosolic N- and C-termini. |journal=FEBS J. |volume=273 |issue= 5 |pages= 1074–86 |year= 2006 |pmid= 16478480 |doi= 10.1111/j.1742-4658.2006.05134.x
*cite journal | author=Weber C, Mello de Queiroz F, Downie BR, "et al." |title=Silencing the activity and proliferative properties of the human EagI Potassium Channel by RNA Interference. |journal=J. Biol. Chem. |volume=281 |issue= 19 |pages= 13030–7 |year= 2006 |pmid= 16537547 |doi= 10.1074/jbc.M600883200
*cite journal | author=Mello de Queiroz F, Suarez-Kurtz G, Stühmer W, Pardo LA |title=Ether à go-go potassium channel expression in soft tissue sarcoma patients. |journal=Mol. Cancer |volume=5 |issue= |pages= 42 |year= 2006 |pmid= 17022811 |doi= 10.1186/1476-4598-5-42
*cite journal | author=Ocorr K, Reeves NL, Wessells RJ, "et al." |title=KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 10 |pages= 3943–8 |year= 2007 |pmid= 17360457 |doi= 10.1073/pnas.0609278104
*cite journal | author=Ding XW, Yan JJ, An P, "et al." |title=Aberrant expression of ether à go-go potassium channel in colorectal cancer patients and cell lines. |journal=World J. Gastroenterol. |volume=13 |issue= 8 |pages= 1257–61 |year= 2007 |pmid= 17451210 |doi=
*cite journal | author=Borowiec AS, Hague F, Harir N, "et al." |title=IGF-1 activates hEAG K(+) channels through an Akt-dependent signaling pathway in breast cancer cells: role in cell proliferation. |journal=J. Cell. Physiol. |volume=212 |issue= 3 |pages= 690–701 |year= 2007 |pmid= 17520698 |doi= 10.1002/jcp.21065

External links

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