CLCN4

Chloride channel 4, also known as CLCN4, is a human gene.cite web | title = Entrez Gene: CLCN4 chloride channel 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1183| accessdate = ]

PBB_Summary
section_title =
summary_text = The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders.cite web | title = Entrez Gene: CLCN4 chloride channel 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1183| accessdate = ]

ee also

* Chloride channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Schnur RE, Wick PA |title=Intragenic TaqI restriction fragment length polymorphism (RFLP) in CICN4, between the loci for X-linked ocular albinism (OA1) and microphthalmia with linear skin defects syndrome (MLS). |journal=Hum. Genet. |volume=95 |issue= 5 |pages= 594–5 |year= 1995 |pmid= 7759088 |doi=
*cite journal | author=van Slegtenhorst MA, Bassi MT, Borsani G, "et al." |title=A gene from the Xp22.3 region shares homology with voltage-gated chloride channels. |journal=Hum. Mol. Genet. |volume=3 |issue= 4 |pages= 547–52 |year= 1994 |pmid= 8069296 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Dinulos MB, Bassi MT, Rugarli EI, "et al." |title=A new region of conservation is defined between human and mouse X chromosomes. |journal=Genomics |volume=35 |issue= 1 |pages= 244–7 |year= 1996 |pmid= 8661129 |doi= 10.1006/geno.1996.0347
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Lamb FS, Clayton GH, Liu BX, "et al." |title=Expression of CLCN voltage-gated chloride channel genes in human blood vessels. |journal=J. Mol. Cell. Cardiol. |volume=31 |issue= 3 |pages= 657–66 |year= 1999 |pmid= 10198195 |doi= 10.1006/jmcc.1998.0901
*cite journal | author=Kawasaki M, Fukuma T, Yamauchi K, "et al." |title=Identification of an acid-activated Cl(-) channel from human skeletal muscles. |journal=Am. J. Physiol. |volume=277 |issue= 5 Pt 1 |pages= C948–54 |year= 1999 |pmid= 10564087 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wang T, Weinman SA |title=Involvement of chloride channels in hepatic copper metabolism: ClC-4 promotes copper incorporation into ceruloplasmin. |journal=Gastroenterology |volume=126 |issue= 4 |pages= 1157–66 |year= 2004 |pmid= 15057754 |doi=
*cite journal | author=Suzuki Y, Yamashita R, Shirota M, "et al." |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604
*cite journal | author=Picollo A, Pusch M |title=Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5. |journal=Nature |volume=436 |issue= 7049 |pages= 420–3 |year= 2005 |pmid= 16034421 |doi= 10.1038/nature03720
*cite journal | author=Huang L, Cao J, Wang H, "et al." |title=Identification and functional characterization of a voltage-gated chloride channel and its novel splice variant in taste bud cells. |journal=J. Biol. Chem. |volume=280 |issue= 43 |pages= 36150–7 |year= 2006 |pmid= 16129671 |doi= 10.1074/jbc.M507706200
*cite journal | author=Littler DR, Assaad NN, Harrop SJ, "et al." |title=Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4. |journal=FEBS J. |volume=272 |issue= 19 |pages= 4996–5007 |year= 2005 |pmid= 16176272 |doi= 10.1111/j.1742-4658.2005.04909.x
*cite journal | author=Okkenhaug H, Weylandt KH, Carmena D, "et al." |title=The human ClC-4 protein, a member of the CLC chloride channel/transporter family, is localized to the endoplasmic reticulum by its N-terminus. |journal=FASEB J. |volume=20 |issue= 13 |pages= 2390–2 |year= 2006 |pmid= 17023393 |doi= 10.1096/fj.05-5588fje

External links

*

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