CACNA2D1

Calcium channel, voltage-dependent, alpha 2/delta subunit 1, also known as CACNA2D1, is a human gene.cite web | title = Entrez Gene: CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=781| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.cite web | title = Entrez Gene: CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=781| accessdate = ]

ee also

* Voltage-dependent calcium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Williams ME, Feldman DH, McCue AF, "et al." |title=Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype. |journal=Neuron |volume=8 |issue= 1 |pages= 71–84 |year= 1992 |pmid= 1309651 |doi=
*cite journal | author=Ellis SB, Williams ME, Ways NR, "et al." |title=Sequence and expression of mRNAs encoding the alpha 1 and alpha 2 subunits of a DHP-sensitive calcium channel. |journal=Science |volume=241 |issue= 4873 |pages= 1661–4 |year= 1988 |pmid= 2458626 |doi=
*cite journal | author=Iles DE, Lehmann-Horn F, Scherer SW, "et al." |title=Localization of the gene encoding the alpha 2/delta-subunits of the L-type voltage-dependent calcium channel to chromosome 7q and analysis of the segregation of flanking markers in malignant hyperthermia susceptible families. |journal=Hum. Mol. Genet. |volume=3 |issue= 6 |pages= 969–75 |year= 1994 |pmid= 7951247 |doi=
*cite journal | author=Brust PF, Simerson S, McCue AF, "et al." |title=Human neuronal voltage-dependent calcium channels: studies on subunit structure and role in channel assembly. |journal=Neuropharmacology |volume=32 |issue= 11 |pages= 1089–102 |year= 1994 |pmid= 8107964 |doi=
*cite journal | author=Powers PA, Scherer SW, Tsui LC, "et al." |title=Localization of the gene encoding the alpha 2/delta subunit (CACNL2A) of the human skeletal muscle voltage-dependent Ca2+ channel to chromosome 7q21-q22 by somatic cell hybrid analysis. |journal=Genomics |volume=19 |issue= 1 |pages= 192–3 |year= 1994 |pmid= 8188232 |doi= 10.1006/geno.1994.1044
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Schleithoff L, Mehrke G, Reutlinger B, Lehmann-Horn F |title=Genomic structure and functional expression of a human alpha(2)/delta calcium channel subunit gene (CACNA2). |journal=Genomics |volume=61 |issue= 2 |pages= 201–9 |year= 1999 |pmid= 10534405 |doi= 10.1006/geno.1999.5941
*cite journal | author=Bell DC, Butcher AJ, Berrow NS, "et al." |title=Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents. |journal=J. Neurophysiol. |volume=85 |issue= 2 |pages= 816–27 |year= 2001 |pmid= 11160515 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Stotz SC, Barr W, McRory JE, "et al." |title=Several structural domains contribute to the regulation of N-type calcium channel inactivation by the beta 3 subunit. |journal=J. Biol. Chem. |volume=279 |issue= 5 |pages= 3793–800 |year= 2004 |pmid= 14602720 |doi= 10.1074/jbc.M308991200
*cite journal | author=Liu T, Qian WJ, Gritsenko MA, "et al." |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065
*cite journal | author=Antzelevitch C, Pollevick GD, Cordeiro JM, "et al." |title=Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death. |journal=Circulation |volume=115 |issue= 4 |pages= 442–9 |year= 2007 |pmid= 17224476 |doi= 10.1161/CIRCULATIONAHA.106.668392
*cite journal | author=Chaudhuri D, Issa JB, Yue DT |title=Elementary mechanisms producing facilitation of Cav2.1 (P/Q-type) channels. |journal=J. Gen. Physiol. |volume=129 |issue= 5 |pages= 385–401 |year= 2007 |pmid= 17438119 |doi= 10.1085/jgp.200709749

External links

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